Depression and Accelerated Aging: The Eveningness Chronotype and Low Adherence to the Mediterranean Diet Are Associated with Depressive Symptoms in Older Subjects DOI Open Access
José V. Sorlí,

Edurne de la Cámara,

Rebeca Fernández-Carrión

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 104 - 104

Published: Dec. 30, 2024

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed association between epigenetic biomarkers aging depressive symptoms. Similarly, limited research has examined joint effects adherence to Mediterranean diet (MedDiet) chronotype on symptoms, accounting for sex differences. Therefore, these are objectives our investigation a population at high cardiovascular risk. Methods: We 465 older subjects (aged 55–75) with metabolic syndrome assessed symptoms by Beck Inventory (BDI-II). MedDiet was measured 17-item score, Morningness–Eveningness Questionnaire (MEQ). Blood DNA methylation analyzed, epigenomic age acceleration were determined. focused Dunedin Pace Aging Computed from Epigenome (DunedinPACE). fitted multivariable models interaction terms. Results: Prevalence depression statistically higher women (p < 0.001). strongly inversely associated whole 0.01), while MEQ score 0.05). In analysis, both remained BDI-II 0.05), showing additive effects. No observed. women, significantly faster (measured DunedinPACE biomarker). This significant even after adjustment chronotype. Conclusions: syndrome, eveningness greater could potentially counteract Women showed stronger associations, importantly, we reported first time this that accelerated aging.

Language: Английский

Depression and Accelerated Aging: The Eveningness Chronotype and Low Adherence to the Mediterranean Diet Are Associated with Depressive Symptoms in Older Subjects DOI Open Access
José V. Sorlí,

Edurne de la Cámara,

Rebeca Fernández-Carrión

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 104 - 104

Published: Dec. 30, 2024

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed association between epigenetic biomarkers aging depressive symptoms. Similarly, limited research has examined joint effects adherence to Mediterranean diet (MedDiet) chronotype on symptoms, accounting for sex differences. Therefore, these are objectives our investigation a population at high cardiovascular risk. Methods: We 465 older subjects (aged 55–75) with metabolic syndrome assessed symptoms by Beck Inventory (BDI-II). MedDiet was measured 17-item score, Morningness–Eveningness Questionnaire (MEQ). Blood DNA methylation analyzed, epigenomic age acceleration were determined. focused Dunedin Pace Aging Computed from Epigenome (DunedinPACE). fitted multivariable models interaction terms. Results: Prevalence depression statistically higher women (p < 0.001). strongly inversely associated whole 0.01), while MEQ score 0.05). In analysis, both remained BDI-II 0.05), showing additive effects. No observed. women, significantly faster (measured DunedinPACE biomarker). This significant even after adjustment chronotype. Conclusions: syndrome, eveningness greater could potentially counteract Women showed stronger associations, importantly, we reported first time this that accelerated aging.

Language: Английский

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