Thinking outside the brain: Gut microbiome influence on innate immunity within neurodegenerative disease

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00476 - e00476

Published: Oct. 1, 2024

The complex network of factors that contribute to neurodegeneration have hampered the discovery effective preventative measures. While much work has focused on brain-first therapeutics, it is becoming evident physiological changes outside brain are best target for early interventions. Specifically, myeloid cells, including peripheral macrophages and microglia, a sensitive population cells whose activity can directly impact neuronal health. Myeloid cell includes cytokine production, migration, debris clearance, phagocytosis. Environmental measures modulate these activities range from toxin exposure diet. However, one most influential mediators fitness gut microenvironment. Here, we review current data about role in gastrointestinal disorders, Parkinson's disease, dementia, multiple sclerosis. We then delve into microbiota modulating therapies available clinical evidence their use neurodegeneration. Modulating lifestyle environmental inflammation promising interventions systematic concerted effort examine healthy aging next frontier.

Language: Английский

Deeper insights into ketogenic diet and stroke study: A Letter to the Editor

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский