Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111260 - 111260
Published: Jan. 22, 2025
Language: Английский
Citations
0The Vagus Nerve-Dependent Lung-Brain Axis Mediates Brain Demyelination Following Acute Lung Injury
Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: 44, P. 100966 - 100966
Published: Feb. 11, 2025
Patients with acute lung injury (ALI) often experience psychiatric and neurological symptoms; however, the precise underlying mechanisms remain unclear. Given that white matter loss (demyelination) contributes to these symptoms, we investigated whether lipopolysaccharide (LPS)-induced ALI leads brain demyelination via a vagus nerve-dependent lung-brain axis. A single intratracheal injection of LPS caused severe in corpus callosum (CC) mouse brains. Subdiaphragmatic vagotomy did not affect LPS-induced or CC. Interestingly, cervical significantly attenuated hypo-locomotion, plasma interleukin-6 levels, CC mice without influencing injury. These findings demonstrate can induce axis, highlighting critical role this pathway symptoms observed patients.
Language: Английский
Citations
0Granola consumption with multiple prebiotics in Japanese participants increases Bifidobacterium abundance and improves stress and subjective sleepiness
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 20, 2025
Background Sleep is essential for physical and mental health. However, stress-related sleep disorders are common in Japan, the gut–brain axis may play a role stress management. This study investigated whether consumption of granola containing multiple prebiotic ingredients could alleviate improve insomnia adults with problems, regardless individual differences gut microbiota. Additionally, we aimed to investigate relationship between changes microbiota observed improvements. Method A single-arm uncontrolled trial was conducted 27 high levels disturbance. The participants consumed 50 g prebiotics-containing daily 8 weeks. Subjective quality assessed using Athens Insomnia Scale, Epworth Oguri-Shirakawa-Azumi Inventory-Middle-aged Aged version (OSA-MA). Stress were by administering Brief Job Questionnaire Profile Mood States 2nd edition (POMS2). Gut composition analyzed 16S rDNA sequencing. Results After weeks, subjective scores onset maintenance improved significantly, whereas mood disturbance decreased significantly. analysis showed that relative abundance Bifidobacterium increased, Bacteroides decreased. Correlation suggested significant association increased level reduced ( r = −0.39, p 0.0035) −0.3, 0.026). Conclusion Prebiotics-containing disturbances, which be attributed alterations microbiota, particularly increase abundance.
Language: Английский
Citations
0Preoperative inflammatory pain exacerbates postoperative pain and neurocognitive impairment
IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0Gut–brain axis modulation by sudachi peel extract enhances resilience to chronic social defeat stress in mice
Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0Role of Antioxidants in Modulating the Microbiota–Gut–Brain Axis and Their Impact on Neurodegenerative Diseases
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3658 - 3658
Published: April 12, 2025
This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.
Language: Английский
Citations
0Disruption in the human microbiome causing behavioural changes in bipolar disorder
International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0Effects of 3,4-methylenedioxymethamphetamine on the gut microbiota and metabolites in the small intestine, cecum, and colon of male rats
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. 111223 - 111223
Published: Dec. 1, 2024
Language: Английский
Citations
1Depression: The Vagus Nerve and Gut-Brain Axis
Published: Jan. 1, 2024
Language: Английский
Citations
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