IUPHAR Review: Microbiota-Gut-Brain Axis and its role in Neuropsychiatric Disorders DOI Creative Commons
Sang‐Ah Lee, Hans‐Jürgen Möller, Cheolmin Shin

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 216, P. 107749 - 107749

Published: April 28, 2025

The human gut microbiome, composed of a vast array microorganisms that have co-evolved with humans, is crucial for the development and function brain systems. Research has consistently shown bidirectional communication between through neuronal, endocrine, immunological, chemical pathways. Recent neuroscience studies linked changes in microbiome microbial metabolites to various neuropsychiatric disorders such as autism, depression, anxiety, schizophrenia, eating disorders, neurocognitive disorders. Novel metagenome-wide association confirmed these variations large samples expanded our understanding interactions genes microbiome. causal relationship microbiota being elucidated establishment cohort incorporating data advanced statistical techniques. Ongoing animal focused on microbiota-gut-brain axis are promising developing new prevention treatment strategies conditions. scope broadened from microbiome-modulating therapies including prebiotics, probiotics, synbiotics postbiotics more extensive approaches fecal transplantation. systematic reviews meta-analyses strengthened evidence base innovative treatments. Despite research over past decade, many intriguing aspects still need be regarding role therapeutic interventions

Language: Английский

IUPHAR Review: Microbiota-Gut-Brain Axis and its role in Neuropsychiatric Disorders DOI Creative Commons
Sang‐Ah Lee, Hans‐Jürgen Möller, Cheolmin Shin

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 216, P. 107749 - 107749

Published: April 28, 2025

The human gut microbiome, composed of a vast array microorganisms that have co-evolved with humans, is crucial for the development and function brain systems. Research has consistently shown bidirectional communication between through neuronal, endocrine, immunological, chemical pathways. Recent neuroscience studies linked changes in microbiome microbial metabolites to various neuropsychiatric disorders such as autism, depression, anxiety, schizophrenia, eating disorders, neurocognitive disorders. Novel metagenome-wide association confirmed these variations large samples expanded our understanding interactions genes microbiome. causal relationship microbiota being elucidated establishment cohort incorporating data advanced statistical techniques. Ongoing animal focused on microbiota-gut-brain axis are promising developing new prevention treatment strategies conditions. scope broadened from microbiome-modulating therapies including prebiotics, probiotics, synbiotics postbiotics more extensive approaches fecal transplantation. systematic reviews meta-analyses strengthened evidence base innovative treatments. Despite research over past decade, many intriguing aspects still need be regarding role therapeutic interventions

Language: Английский

Citations

0