Exploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system DOI Creative Commons
José Enrique de la Rubia Ortí, María Cuerda‐Ballester, Claudia Emmanuela Sanchis-Sanchis

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 25, 2023

Multiple sclerosis (MS) is a neurodegenerative disorder. Individuals with MS frequently present symptoms such as functional disability, obesity, and anxiety depression. Axonal demyelination can be observed implies alterations in mitochondrial activity increased inflammation associated disruptions glutamate neurotransmitter activity. In this context, the ketogenic diet (KD), which promotes production of ketone bodies blood [mainly β-hydroxybutyrate (βHB)], non-pharmacological therapeutic alternative that has shown promising results peripheral obesity reduction central reduction. However, association type emotional through modulation individuals remains unknown.To provide an update on topic discuss potential impact KD depression subjects MS.The main findings suggest KD, source blood, improves by reducing insulin resistance dyslipidemia, promoting (particularly increase interleukins IL-1β, IL-6, IL-17). This improvement would imply decrease extrasynaptic activity, been linked to disability presence disorders

Language: Английский

Nitric oxide involvement in the disability and active disease of multiple sclerosis: Systematic review and meta-analysis DOI
Brenda da Silva, Fernanda Tibolla Viero, Patrícia Rodrigues

et al.

Nitric Oxide, Journal Year: 2024, Volume and Issue: 145, P. 8 - 20

Published: Feb. 6, 2024

Language: Английский

Citations

4
Longitudinal measurement invariance and psychometric properties of the Patient Health Questionnaire-Four in China DOI Creative Commons
Runtang Meng, Chen Jiang,

Joseph M. Dzierzewski

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 22, 2024

Abstract Background Depression and anxiety symptoms among medical students are often a concern. The Patient Health Questionnaire-Four (PHQ-4), an important tool for depression screening, is commonly used easy to administer. This study aimed assess update the longitudinal measurement invariance psychometric properties of simplified Chinese version. Methods A three-wave survey was conducted healthcare using PHQ-4. Structural validity based on one-factor, two-factor, second-order factor models, construct Self-Rated Questionnaire (SRHQ), Sleep Quality (SQQ), Rosenberg Self-Esteem Scale (RSES), (LMI), internal consistency, test–retest reliability were structural consistency across three time points. Results results confirmatory analysis indicated that two-factor model best fit, LMI supported at Inter-factor, factor-total, correlations PHQ-4 acceptable. Additionally, Cronbach’s alpha, McDonald’s omega, intraclass correlation coefficient demonstrated acceptable/moderate excellent Conclusions adds new evidence version has promising properties. Such data lends confidence routine expanded use screening in students.

Language: Английский

Citations

4
PANORAMA: A 2021 Clinician Survey of Treatment Approaches for People With New Diagnoses of Relapsing-Remitting Multiple Sclerosis in the United Kingdom DOI Open Access
Nikos Evangelou, Miriam Mattoscio,

Mhairi Coutts

et al.

International Journal of MS Care, Journal Year: 2025, Volume and Issue: 27(Q1), P. 1 - 7

Published: Jan. 6, 2025

ABSTRACT BACKGROUND: The PANORAMA survey aimed to assess current treatment practice for individuals with new diagnoses of relapsing-remitting multiple sclerosis (RRMS) in the United Kingdom and explore variations approaches an emphasis on escalation vs early high-efficacy (HET) goals. METHODS: Health care professionals (HCPs) from UK treating patients RRMS took part interviews facilitated by a structured questionnaire. Data were analyzed descriptively using quantitative or qualitative methods, as appropriate. RESULTS: Thirty-eight HCPs 38 centers survey, including 20 MS consultants 13 specialist nurses. Seventy-four percent (n = 28 38) strongly agreed 24% (9 that is essential better outcomes. reported they currently treat mean (SD) 58.3% (20.8%) 42.1% (21.8%) HET approaches, respectively. Thirty-four (13 discrepancy between approach would like take, which be 66.2% favoring 33.8% approaches. factors influencing choice overall patient health profile (45%, 17 (39%, 15 38). most important goals reduce relapses (63%, 24 38), delay disability progression (58%, 22 maintain quality life (50%, 19 CONCLUSIONS: highlights variation among ideal use approach.

Language: Английский

Citations

0
Prevalence and network structure of depression, anxiety and adverse doctor-patient relationship risks among patients with physical diseases: A cross-sectional study DOI
Jianqiang Wang,

Yuru Du,

Yuzhu Peng

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in repetitive transcranial magnetic stimulation in the treatment of treatment-resistant depression: a comprehensive review DOI
Hui Xing, Xiaolei Liu, Yingying Zhang

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract Major depressive disorder is a common mental disorder, and significant number of patients exhibit poor response to conventional antidepressant treatments, known as treatment-resistant depression (TRD). However, the definition TRD globally remains unclear, impeding clinical research, treatment development, outcome implementation, policy-making. A wealth research confirms that rTMS demonstrates promising efficacy in TRD. This paper elucidates TRD, summarizes potential targets for treating comprehensively elaborates on unique mechanisms, efficacy, side effects outlines considerations special populations receiving well other modalities Through these studies, we aim provide more scientifically grounded recommendations undergoing

Language: Английский

Citations

0
The Dimensionality of Well-Being in People With Multiple Sclerosis: A Hierarchical Confirmatory Factor Analysis DOI Creative Commons
Beatrice Lee, Teresa Granger, Deyu Pan

et al.

Rehabilitation Counseling Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Multiple sclerosis (MS) has been linked to numerous challenges that affect well-being due its unpredictable nature and debilitating symptoms. The study seeks evaluate the psychometric properties factor structure of PERMA-Profiler, a assessment tool within context MS. A confirmatory factory analysis was performed test structural validity. revealed correlated five-factor, indicating encompasses multiple dimensions for individuals living with Reliability indicated high internal consistency all factors except engagement. Validity supported through correlations measures disability-related stress functional limitations. These findings suggested PERMA-Profiler is reliable valid instrument can be used assessing among Overall, offers promising avenue understanding promoting in MS population, implications tailored interventions holistic care approaches.

Language: Английский

Citations

0
Anxiety and Cognition in Multiple Sclerosis: A Narrative Review DOI Open Access

Roberto Martin Susini,

Natalia Ciufia,

Aldana Marinangeli

et al.

International Journal of MS Care, Journal Year: 2025, Volume and Issue: 27(Q1), P. 63 - 73

Published: March 3, 2025

People with multiple sclerosis (MS) often experience psychiatric symptoms, such as anxiety and depression, that impact disease progression quality of life. Cognitive impairment, particularly in processing speed episodic memory, is common MS. There are several studies studying the relationship between cognition population This study reviews literature. bibliographic review covers publications Spanish English from January 2006 to June 2022. It focuses on quantitative investigations symptoms cognitive variables people A majority found an association Anxiety significantly affects information speed, learning, attention, working verbal fluency However, some find no association. The depressive bidirectional highlighted. MS associated impairment. Further research needed understand mechanisms establish causal relationships this population.

Language: Английский

Citations

0
Understanding Depression in People Living with Multiple Sclerosis: A Narrative Review of Recent Literature DOI Creative Commons
Amy B. Sullivan, Bryan E. Davis,

Julie K. Kidd

et al.

Neurology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Multiple sclerosis (MS) is a chronic neurodegenerative and autoimmune disease that affects approximately 1 million adults in the US. Psychologic disorders are typical comorbidities people with MS (pwMS), depression being most common. Clinical pwMS can substantially impact quality of life factor heavily treatment adherence. Depression surface early MS, becoming more prevalent as progresses severity clinical disability increases. The etiology comorbid not completely understood, but recent research has indicated structural functional brain abnormalities, along genetic immunologic factors, may contribute to pathogenesis pwMS. Although significant on pwMS, it often underdiagnosed undertreated. Furthermore, efficacy pharmacologic non-pharmacologic approaches for treating been thoroughly investigated, studies showing minimal or no beneficial effect. Improved evaluation diagnosis better understanding its pathophysiology provide stronger foundation management suffering from depression. This review discusses potential causes depression, risk factors associated developing overall It also reviews patient-reported outcomes utilized assess disease-modifying therapies Consideration given (both non-pharmacologic) facilitate patient journey.

Language: Английский

Citations

0
Trauma Burden Affected People with Multiple Sclerosis During SARS-CoV-2 Pandemic DOI Open Access
Felicita Heidler, Michael Hecker, Niklas Frahm

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2665 - 2665

Published: April 13, 2025

Background/Objectives: Trauma is a psychological injury resulting from distressing or overwhelming event. The SARS-CoV-2 pandemic has been disruptive and traumatic for many people with multiple sclerosis (pwMS). relationship between patient characteristics trauma in pwMS during the not yet thoroughly explored. aim of this bicentric prospective cohort study was to analyze prevalence development probable post-traumatic stress disorder (PTSD) among identify parameters associated condition. Methods: We have assessed PTSD before after approval first vaccines Germany using an adapted version Screening Questionnaire (TSQ). compared (TSQ sum score ≥ 6) those without < regarding sociodemographic MS-specific clinical characteristics, polypharmacy status, comorbidities, anxiety/depression levels, personality traits, mental/physical/social burden, general vaccination willingness. Results: Out 149 included, 8.1% were identified as having PTSD. These patients had significantly higher rates pre-pandemic abnormal anxiety (66.7% vs. 18.5%, p 0.001) depression scores (45.5% 12.6%, = 0.013). exhibited distinct profile, neuroticism harm avoidance lower conscientiousness, cooperativeness, self-directedness scores. They also more likely report severe very burdens (p ≤ 0.045). Conclusions: Medical social services should be provided support who experienced serious trauma. concepts education procedures accompanied by comprehensive clear communication that recognizes individual risk factors addresses possible concerns evidence-based convincing arguments.

Language: Английский

Citations

0
The prevalence of major depression and generalized anxiety disorder in patients with multiple sclerosis in Saudi Arabia: a cross-sectional multicentered study DOI Creative Commons

Anas M Alswat,

Bsaim A. Altirkistani,

Anas R. Alserihi

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 29, 2023

Multiple sclerosis (MS) is an autoimmune disease characterized by chronic, progressive neurodegeneration of the central nervous system (CNS), and it most common inflammatory neurological affecting young adults. Given nature disease, psychiatric disorders are more prevalent among these patients, as reported in literature; however, data Saudi Arabia limited. This study aimed to estimate prevalence major depression generalized anxiety disorder patients with MS their association different patient demographics.This was a cross-sectional, multicentered that included adult from 30 June 2021 2022. Participants were interviewed person asked complete survey general demographics, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7) questionnaire. Other variables related patients' conditions, such type Expanded Disability Status Scale (EDSS) score, collected patient's electronic records. Descriptive statistics performed, associations made using chi-square, Fisher's exact, analysis variance tests, appropriate.A total 192 participants this study. Based on cutoff score >10 GAD-7 PHQ-9 scales, 26.1% (50), majority having minimal (40%); meanwhile, 42.7% (n = 82), them had mild (30%). Female scored significantly higher compared men scale (p 0.0376), but not 0.1134). In addition, no statistically significant detected between functional disability (EDSS score) depression.This demonstrated high population, women being affected. As comorbid could negatively affect course, screening paramount significance.

Language: Английский

Citations

10