The plasma metabolome of long COVID patients two years after infection

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 1, 2023

Abstract One of the major challenges currently faced by global health systems is prolonged COVID-19 syndrome (also known as “long COVID”) which has emerged a consequence SARS-CoV-2 epidemic. It estimated that at least 30% patients who have had will develop long COVID. In this study, our goal was to assess plasma metabolome in total 100 samples collected from healthy controls, patients, and COVID recruited Mexico between 2020 2022. A targeted metabolomics approach using combination LC–MS/MS FIA MS/MS performed quantify 108 metabolites. IL-17 leptin were measured immunoenzymatic assay. The comparison paired COVID-19/long revealed 53 metabolites statistically different. Compared 27 remained dysregulated even after two years. Post-COVID-19 displayed heterogeneous metabolic profile. Lactic acid, lactate/pyruvate ratio, ornithine/citrulline arginine identified most relevant for distinguishing with more complicated evolution. Additionally, levels significantly increased these patients. Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, chronic immune dysregulation are likely be main hallmarks years acute infection.

Language: Английский

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Markers of limbic system damage following SARS-CoV-2 infection

Brain Communications, Journal Year: 2023, Volume and Issue: 5(4)

Published: Jan. 1, 2023

Alterations of the limbic system may be present in chronic phase SARS-CoV-2 infection. Our aim was to study long-term impact this disease on system-related behaviour and its associated brain functional connectivity, according severity respiratory symptoms acute phase. To end, we investigated multimodal emotion recognition abilities 105 patients from Geneva COVID-COG Cohort 223 days average after infection (diagnosed between March 2020 May 2021), dividing them into three groups (severe, moderate or mild) symptom We used multiple regressions partial least squares correlation analyses investigate relationships recognition, olfaction, cognition, neuropsychiatric networks. Six 9 months following infection, exhibited poorer than mild for expressions fear (P = 0.03 corrected), as did severe disgust 0.04 corrected) irritation < 0.01 corrected). In whole cohort, these performances were with decreased episodic memory anosmia, but not depressive symptoms, anxiety post-traumatic stress disorder. Neuroimaging revealed a positive contribution notably cerebellum default mode, somatosensory motor salience/ventral attention These results highlight consequences SARS-Cov-2 at both behavioural neuroimaging levels.

Language: Английский

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Persistence and emergence of new neuropsychological deficits following SARS-CoV-2 infection: A follow-up assessment of the Geneva COVID-COG cohort

Journal of Global Health, Journal Year: 2024, Volume and Issue: 14

Published: March 7, 2024

Despite numerous observations of neuropsychological deficits immediately following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, little is known about what happens to these over time and whether they are affected by changes in fatigue any psychiatric symptoms. We aimed assess the prevalence at 6-9 months again 12-15 after disease 2019 (COVID-19) explore it was associated with

Language: Английский

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Acute TNFα levels predict cognitive impairment 6–9 months after COVID-19 infection

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 153, P. 106104 - 106104

Published: April 1, 2023

A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack awareness memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic networks, an elevated monocyte count. However, relationship between these cognitive brain alterations chronic phase with level cytokines during acute yet to be identified. Determine whether cytokine type levels associated anosognosia patterns 6–9 months after infection. We analyzed predictive value concentration (IL-1RA, IL-1β, IL-6, IL-8, IFNγ, G-CSF, GM-CSF) (cytokine panel multiplex immunoassay) plasma 39 patients (mean age 59 yrs, 38–78) relation their scores for deficits via stepwise linear regression. Then, associations different were MRI multivariate partial least squares correlations whole group. Stepwise regression modeling allowed us show TNFα predicted (R2 = 0.145; β −0.38; p .017) (r −0.587; < .001) observed post-infection. Finally, high hippocampal, temporal pole, accumbens nucleus, amygdala, cerebellum connectivity. Increased COVID-19 predict presence long-term changes system

Language: Английский

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Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?

Reports — Medical Cases Images and Videos, Journal Year: 2023, Volume and Issue: 6(3), P. 36 - 36

Published: Aug. 1, 2023

In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more than a norepinephrine precursor, was brain neurotransmitter in and of itself. By 1963, postsynaptic dopamine blockade had become cornerstone psychiatric treatment as it appeared have deciphered “chlorpromazine enigma”, 1950s term, denoting action mechanism antipsychotic drugs. The same year, Lindqvist launched hypothesis schizophrenia, ushering era psychopharmacology. At present, six decades later, although watered down by three consecutive revisions, model remains vogue. latest emendation this paradigm proposes “environmental genetic factors” converge on dopaminergic pathways, upregulating transmission. Aryl hydrocarbon receptors, expressed gut blood–brain barrier, respond variety endogenous exogenous ligands, including probably participating interoceptive awareness, feed-back loop, conveying intestinal barrier status insular cortex. conceptualization aryl receptor bridge, connecting vagal terminals with microbiome, may elucidate aspects schizophrenia seemingly incongruous hypothesis, such increased prevalence urban areas, distance from equator, autoantibodies, or comorbidity inflammatory bowel disease human immunodeficiency 1 virus. review article, after short discussion outcome studies insight, we take closer look drugs, attempting answer question: do these agents exert their beneficial effects via both nondopaminergic mechanisms? Finally, discuss potential new therapies, transcutaneous stimulation, restoring homeostasis barrier.

Language: Английский

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The plasma metabolome of long COVID-19 patients two years after infection

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 5, 2023

ABSTRACT Background One of the major challenges currently faced by global health systems is prolonged COVID-19 syndrome (also known as “long COVID”) which has emerged a consequence SARS-CoV-2 epidemic. The World Health Organization (WHO) recognized long COVID distinct clinical entity in 2021. It estimated that at least 30% patients who have had will develop COVID. This put tremendous strain on still-overstretched healthcare around world. Methods In this study, our goal was to assess plasma metabolome total 108 samples collected from healthy controls, patients, and recruited Mexico between 2020 2022. A targeted metabolomics approach using combination LC-MS/MS FIA MS/MS performed quantify metabolites. IL-17 leptin concentrations were measured immunoenzymatic assay. Results comparison paired COVID-19/post-COVID-19 revealed 53 metabolites statistically different (FDR < 0.05). Compared 29 remained dysregulated even after two years. Notably, glucose, kynurenine, certain acylcarnitines continued exhibit altered similar phase, while sphingomyelins saturated monounsaturated LysoPCs, phenylalanine, butyric acid, propionic acid levels normalized. Post-COVID-19 displayed heterogeneous metabolic profile, with some showing no symptoms others exhibiting variable number symptoms. Lactic lactate/pyruvate ratio, ornithine/citrulline sarcosine, arginine identified most relevant for distinguishing more complicated evolution. Additionally, significantly increased these patients. Conclusions Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, chronic immune dysregulation are likely be main hallmarks years acute infection.

Language: Английский

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Laboratory profiling of patients with long COVID in the Brazilian Amazon region: A cross‐sectional study

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(8)

Published: July 31, 2024

Abstract The condition commonly referred to as long coronavirus disease (COVID) is characterized by the continuation of symptoms, sometimes accompanied new symptoms that persist after resolution acute 2019 (COVID‐19). This observational cross‐sectional study investigated 332 patients with COVID in Brazilian Amazon region. aimed elucidate systemic interactions associated compiling findings related hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants were identified using rigorous criteria underwent thorough laboratory examinations. obtained data subsequently analyzed, allowing for comparisons, associations, correlations between within distinct groups study. Significant associations observed hospitalization during phase persistent abnormalities, suggesting a potential link severity long‐term effects. Notably, individuals over year exhibited elevated levels monocytes, prolonged prothrombin times, reduced activity, high lactate dehydrogenase, an increased frequency qualitative C‐reactive protein detection. provides valuable insights into risk profile COVID, particularly unique context region, where exhibit lasting up 1261 days.

Language: Английский

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Long Coronavirus Disease and the Brain

PET Clinics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Coronavirus disease 2019 and its impact on the cognition of older adults: Unraveling the role of inflammation

Comprehensive Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 19, P. 100238 - 100238

Published: May 8, 2024

The Coronavirus Disease 2019 (COVID-19) pandemic significantly impacted the older adult population globally. This study aimed to investigate cognitive function and its relationship with inflammation in COVID-19 survivors over a three-month follow-up address concerns about impairment risk factors.

Language: Английский

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WITHDRAWN: Coronavirus Disease 2019 and its Impact on the Cognition of Older Adults: Unraveling the Role of Inflammation

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

Background: The Coronavirus Disease 2019 (COVID-19) pandemic has had a significant global impact, particularly on the older adult population. To address concerns regarding emergence and persistence of cognitive impairment its potential risk factors, this study aimed to investigate function relationship with inflammation in COVID-19 survivors during three-month follow-up. Methods: In descriptive-analytical study, 177 hospitalized patients aged >60 years were examined between July 2021 February 2022.Psychiatric assessments conducted at discharge one month three months post-discharge. All statistical analyses using Statistical Package for Social Sciences (SPSS) version 24 (P<0.05). Cognitive status was analyzed Repeated Measures Test, relationships inflammatory indices explored via Pearson correlation test Mann‒Whitney U test. normality data Kolmogorov‒Smirnov Results:A assessment indicated lower scores onthe informant subscales General Practitioner Assessment Cognition (GPCOG) time discharge, as well 1-and 3-month follow-up intervals. Negative correlations found depression/anxiety. Elevated C-reactive protein (CRP), D-dimer, Lactate dehydrogenase (LDH) levels linked scores, while Erythrocyte sedimentation rate (ESR) Creatine phosphokinase (CPK) not significantly correlated. Over time, anxiety improved, depression daily activity challenges persisted. Conclusions: This highlights lingering impact cognition among survivors. Moreover, these findings underscore urgent need focused interventions rehabilitation efforts foster sustained recovery

Language: Английский

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