Comment on Chaparro-Solano et al.: “Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review.” Parkinsonism Relat Disord. 2025 Jan;130:107206.

Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 107774 - 107774

Published: March 1, 2025

Language: Английский

---

Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 269, P. 36 - 47

Published: May 8, 2024

Language: Английский

---

Profiling deutetrabenazine extended-release tablets for tardive dyskinesia and chorea associated with Huntington’s disease

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(9), P. 849 - 863

Published: July 9, 2024

Tardive dyskinesia (TD) and Huntington's disease (HD)-associated chorea are persistent disabling hyperkinetic disorders that can be treated with vesicular monoamine transporter type 2 (VMAT2) inhibitors, including the recently approved once-daily (QD) formulation of deutetrabenazine (DTBZ ER). While its efficacy safety profile have not been directly investigated, currently available data confirms bioequivalence similar bioavailability to twice-daily BID).

Language: Английский

---

Suicidal Ideation and Self-harming Thoughts With Valbenazine Use

Journal of Clinical Psychopharmacology, Journal Year: 2024, Volume and Issue: 44(6), P. 596 - 598

Published: Oct. 15, 2024

Neeman, Jake PharmD; Lang, Shelby E. PharmD, BCPP; Jiao, Jianwei MD, PhD Author Information

Language: Английский

---

Analysis of schizophrenia‐associated genetic markers in the HLA region as risk factors for tardive dyskinesia

Human Psychopharmacology Clinical and Experimental, Journal Year: 2024, Volume and Issue: 39(4)

Published: April 27, 2024

Abstract Objectives The pathology of Tardive Dyskinesia (TD) has yet to be fully understood, but there have been proposed hypotheses for the cause this condition. Our team previously reported a possible association TD with Complement Component C4 gene in HLA region. In study, we explored region further by examining two identified schizophrenia‐associated HLA‐region single‐nucleotide polymorphisms (SNPs), namely rs13194504 and rs210133. Methods SNPs rs210133 were tested occurrence severity sample 172 schizophrenia patients who recruited four studies from three different clinical sites Canada USA. Results AA genotype was associated decreased as measured Abnormal Involuntary Movement Scale (AIMS) scores ( p = 0.047) not occurrence. SNP significantly either or AIMS scores. Conclusion findings suggest that may play role severity, while major risk TD.

Language: Английский

---

Synthesis and Characterization of New Hexahydroquinoline Derivatives, Evaluation of Their Cytotoxicity, Intracellular ROS Production and Inhibitory Effects on Inflammatory Mediators

TURKISH JOURNAL OF CHEMISTRY, Journal Year: 2024, Volume and Issue: 48(4), P. 659 - 675

Published: Aug. 20, 2024

Inflammation is a response to injury and infection in an organism. It can be categorized as acute or chronic. Chronic inflammation the underlying cause of many diseases such Alzheimer disease, diabetes, rheumatoid arthritis, atherosclerosis, cardiovascular diseases. Recent studies have proven antiinflammatory properties 1,4-dihydropyridines (1,4-DHPs) their derivatives, which biological activities including blocking calcium channels. In this study, 15 compounds that are condensed derivatives 1,4-DHPs, with general structure hexahydroquinoline-3-carboxylate, were synthesized. These compounds, expected show inhibitory activity against inflammatory mediators, obtained by reaction 4-(difluoromethoxy)benzaldehyde, substituted/nonsubstituted 1,3-cyclohexanedione appropriate alkyl acetoacetate presence ammonium acetate nitrogen source according Hantzsch synthesis method. The structures synthesized elucidated IR,

Language: Английский

---

The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9691 - 9691

Published: Sept. 7, 2024

Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are androgen excess disorders requiring the determination of classic levels for diagnosis. 11-oxygenated androgens have high androgenic potential, yet their clinical value in those is not clear. Additionally, role endocrine disruptors (EDs), particularly IH, remains understudied. We analyzed 25 steroids 18 EDs plasma samples from women with PCOS, controls using LC-MS/MS. Cytokine metabolic parameters were assessed. Comparisons included non-obese PCOS (n = 10), IH 12) 20), versus obese 9). Higher observed compared to but controls. Conversely, lower did differ between Bisphenol A (BPA) higher PCOS. S occurrence was (90%) (65%) (50%). Significant correlations found (11-ketotestosterone, androstenedione, testosterone) insulin HOMA-IR, as well immunomodulatory 7-oxygenated metabolites DHEA nine interleukins. Our data confirms that a multiendocrine gland disorder. BPA might exacerbate abnormalities. confirmed an inflammatory state, no differences suggest does play pathogenesis.

Language: Английский

---

Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Language: Английский

---

Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia

Brain Research, Journal Year: 2023, Volume and Issue: 1826, P. 148740 - 148740

Published: Dec. 22, 2023

Language: Английский

---