Novel Nanoliposomes Synergistically Modulated by Sitogluside and Dioscin: Stability, Bioavailability, and Capacity To Alleviate Hyperuricaemia DOI

Gaodan Liu,

Jingjian Liu,

Ping Shao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Cholesterol (Cho) is commonly used to stabilize nanoliposomes; however, there controversy on the relationship between Cho and health. In this study, we developed a novel multifunctional nanoliposome utilizing structurally similar sitogluside (SG) dioscin (Dio) instead of anchor phospholipid bilayer synergistically modulate membrane properties (DPPC or DOPC). The storage gastrointestinal tract stability experiment demonstrated that changes physical chemical properties, including significantly reduced size Dio retention rate nanoliposomes modulated by SG compared those alone, regulated nanoliposomes. Moreover, stabilization effect DPPC under synergistic modulation was superior DOPC Similarly, in cell internalization permeability studies, DPPC-sitogluside-dioscin (P-SG-Dio), which Dio, had highest cellular uptake transepithelial transport. addition, with DPPC-cholesterol-dioscin (P-Cho-Dio) free intragastric administration P-SG-Dio for 14 days could effectively inhibit activation NLRP3 inflammatory pathway kidney hyperuricemic mice, exhibiting best antihyperuricemic anti-inflammatory effects. Fourier transform infrared Raman spectroscopy results indicated glucose residues forming hydrogen bonds them polar heads phospholipids. absence unsaturated led modulation, resulting stability, bioavailability P-SG-Dio. finding offers valuable insight into design modification effective delivery bioactive compounds.

Language: Английский

Polysaccharides, saponins and flavonoids in Astragali Radix: a review of phytochemistry and pharmacology for future therapeutic applications DOI
Xiaolin Huang,

Ziyuan Guo,

Zihan Wang

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Novel Nanoliposomes Synergistically Modulated by Sitogluside and Dioscin: Stability, Bioavailability, and Capacity To Alleviate Hyperuricaemia DOI

Gaodan Liu,

Jingjian Liu,

Ping Shao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Cholesterol (Cho) is commonly used to stabilize nanoliposomes; however, there controversy on the relationship between Cho and health. In this study, we developed a novel multifunctional nanoliposome utilizing structurally similar sitogluside (SG) dioscin (Dio) instead of anchor phospholipid bilayer synergistically modulate membrane properties (DPPC or DOPC). The storage gastrointestinal tract stability experiment demonstrated that changes physical chemical properties, including significantly reduced size Dio retention rate nanoliposomes modulated by SG compared those alone, regulated nanoliposomes. Moreover, stabilization effect DPPC under synergistic modulation was superior DOPC Similarly, in cell internalization permeability studies, DPPC-sitogluside-dioscin (P-SG-Dio), which Dio, had highest cellular uptake transepithelial transport. addition, with DPPC-cholesterol-dioscin (P-Cho-Dio) free intragastric administration P-SG-Dio for 14 days could effectively inhibit activation NLRP3 inflammatory pathway kidney hyperuricemic mice, exhibiting best antihyperuricemic anti-inflammatory effects. Fourier transform infrared Raman spectroscopy results indicated glucose residues forming hydrogen bonds them polar heads phospholipids. absence unsaturated led modulation, resulting stability, bioavailability P-SG-Dio. finding offers valuable insight into design modification effective delivery bioactive compounds.

Language: Английский

Citations

0