Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder DOI Creative Commons
Dylan Kirsch, Erica N. Grodin, Steven J. Nieto

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(11), P. 1719 - 1728

Published: May 13, 2024

Early life stress (ELS) increases risk for psychiatric illness, including alcohol use disorder (AUD). Researchers have hypothesized that individuals with and without a history of ELS who the same primary DSM-5 diagnosis are clinically biologically distinct. While there is strong support this hypothesis in context mood disorders, remains largely untested AUD. This study investigated impact on neuroclinical phenomenology inflammatory profile Treatment-seeking adults AUD (N = 163) completed Adverse Childhood Experiences (ACE) Questionnaire phenotypic battery as part pharmacotherapy trial (NCT03594435). Participants were classified having "no-ELS," (ACE 0) "moderate-ELS," 1, 2 or 3) "high-ELS" 4 + ). The Addictions Neuroclinical Assessment domains incentive salience negative emotionality derived used to assess We tested (1) cumulative predictor ANA (2) group differences domains. A subset participants 98) provided blood samples biomarker peripheral inflammation (C-reactive protein; CRP); analyses repeated CRP outcome variable. Greater predicted higher elevated CRP, but not salience. high-ELS exhibited greater compared no-ELS moderate-ELS groups, no difference between latter two groups. no/moderate-ELS group. Findings suggest exposure associated unique presentation marked by emotionality, characterized CRP.

Language: Английский

Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder DOI Creative Commons
Dylan Kirsch, Erica N. Grodin, Steven J. Nieto

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(11), P. 1719 - 1728

Published: May 13, 2024

Early life stress (ELS) increases risk for psychiatric illness, including alcohol use disorder (AUD). Researchers have hypothesized that individuals with and without a history of ELS who the same primary DSM-5 diagnosis are clinically biologically distinct. While there is strong support this hypothesis in context mood disorders, remains largely untested AUD. This study investigated impact on neuroclinical phenomenology inflammatory profile Treatment-seeking adults AUD (N = 163) completed Adverse Childhood Experiences (ACE) Questionnaire phenotypic battery as part pharmacotherapy trial (NCT03594435). Participants were classified having "no-ELS," (ACE 0) "moderate-ELS," 1, 2 or 3) "high-ELS" 4 + ). The Addictions Neuroclinical Assessment domains incentive salience negative emotionality derived used to assess We tested (1) cumulative predictor ANA (2) group differences domains. A subset participants 98) provided blood samples biomarker peripheral inflammation (C-reactive protein; CRP); analyses repeated CRP outcome variable. Greater predicted higher elevated CRP, but not salience. high-ELS exhibited greater compared no-ELS moderate-ELS groups, no difference between latter two groups. no/moderate-ELS group. Findings suggest exposure associated unique presentation marked by emotionality, characterized CRP.

Language: Английский

Citations

7