Medial prefrontal cortex and nucleus reuniens are critical for working memory in an operant delayed nonmatch task

Published: July 3, 2024

Abstract Working memory refers to the temporary retention of a small amount information used in execution cognitive task. The prefrontal cortex and its connections with thalamic subregions are thought mediate specific aspects working memory, including engaging hippocampus retrieval. We an operant delayed-non match position task, which does not require hippocampus, determine roles rodent medial (mPFC), nucleus reuniens region (RE), their connection. found that transient inactivation mPFC RE using GABA-A agonist muscimol led delay-independent reduction behavioral performance delayed non-match paradigm. Critically, we chemogenetic approach directionality necessary circuitry for reliant on memory. Specifically, when targeted neurons project (mPFC-RE) delay- independent but (RE-mPFC). Our results suggest broader role mPFC-RE circuit mediating beyond connection hippocampus.

Language: Английский

Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task

Neurobiology of Learning and Memory, Journal Year: 2024, Volume and Issue: unknown, P. 108007 - 108007

Published: Nov. 1, 2024

Language: Английский