The Legalome: Microbiology, Omics and Criminal Justice DOI Creative Commons
Alan C. Logan, Pragya Mishra, Susan L. Prescott

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential DOI Creative Commons
Inès Hadrich, M. Turki, I. Chaâri

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

The human gut mycobiome, a minor but integral component of the microbiome, has emerged as significant player in host homeostasis and disease development. While bacteria have traditionally been focus microbiome studies, recent evidence suggests that fungal communities (mycobiota) may also play crucial role modulating health, particularly neuropsychiatric disorders. This review aims to provide comprehensive overview current knowledge on relationship between mycobiome disorders, exploring potential targeting novel therapeutic strategy. We summarized findings from metagenomic analyses characterize diversity composition mycobiota discuss how these interact with other microorganisms via gut-brain axis. Key methodologies for studying mycobiota, such high-throughout sequencing bioinformatics approaches, were reviewed highlight advances field. Emerging research links dysbiosis conditions schizophrenia, Alzheimer's disease, autism spectrum bipolar disorder, depression. Studies indicate specific populations, Candida Saccharomyces, influence neuroinflammation, permeability immune responses, thereby affecting mental health outcomes. Understanding mycobiome's disorders opens new avenues interventions, including antifungal treatments, probiotics, dietary modifications. Future should integrate multi-omics approaches unravel complex interkingdom interactions within ecosystem, paving way personalized medicine care.

Language: Английский

Citations

2
The Legalome: Microbiology, Omics and Criminal Justice DOI Creative Commons
Alan C. Logan, Pragya Mishra, Susan L. Prescott

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

Citations

0