Effects of Melatonin Supplementation on Muscle Strength, Manual Dexterity, and Postural Balance in Patients Living with Multiple sclerosis - A Randomized Controlled Trial

Journal of Dietary Supplements, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: Jan. 23, 2025

Our previous study revealed the benefits of chronic melatonin intake on dynamic postural imbalance and poor walking capacity induced by multiple sclerosis but its impact muscle weakness manual dexterity related to this disease has not yet been explored. The objective current was investigate effectiveness 12-week supplementation motor skills (i.e., strength, dexterity, static balance) psycho-cognitive status among patients. For that, twenty-seven patients were divided into group (MG, n = 15) placebo (PG, 12). Melatonin each taken at a dose 3 mg per night, 30 min before bedtime, for 12 weeks. Before after intervention, we assessed isokinetic knee strength (dynamometer), (Nine-Hole Peg Test (NHPT)), balance (force platform), mood (Hospital Anxiety Depression Scale (HADS)), cognition (Montreal Cognitive Assessment (MoCA), Symbol Digit Modalities (SDMT), Trail Making (TMT)). results showed that peak torques flexors (120°/s: p 0.015, Hedges'g (g) 1.84; 180°/s: 0.02, g 2.06) extensors 0.019, 1.63; 0.03, 2.01) increased in MG comparatively with PG. There also decrease sway area (bipedal stance) mediolateral amplitude (unipedal center pressure compared PG eyes-open (both: < 0.001; 4.32, 1.99, respectively) eyes-closed (p 0.0007, 1.31; 0.003, 1.79, conditions. an increase MoCA 0.0006, 1.51) SDMT 0.95) scores, as well HADS-Total score 0.012, 1.06), TMT 0.91) NHPT durations 0.001, 2.36) Based study, effective improving balance, mood, clinical trial regsitration, prospectively recorded Pan African Clinical Trial Registry (PACTR202007465309582).

Language: Английский

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Static postural balance and manual dexterity are sex-dependent among a sample of relapsing-remitting multiple sclerosis patients

Neurological Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: April 1, 2025

Sex differences in physical, psycho-cognitive and sleep disorders, neuropathic pain perceived fatigue related to multiple sclerosis (MS) have been studied, but contradictory findings were found. MS studies regarding difference between men women postural balance are very scarce based on subjective assessments. We aimed investigate the sex effects other physical measures among a sample of patients. Data from 8 12 with compared. The assessed parameters were: static dynamic (force platform), manual dexterity (Nine Hole Peg Test (NHPT)), leg muscle strength (Five-Repetition Sit-To-Stand Test), functional mobility (Timed up Go walking speed 25-Foot Walk fall risk (Four Square Step cognitive functions (Montreal assessment (MOCA) React software), (Neuropathic Pain Questionnaire 4 (DN4)), (Hooper index), mood (Hospital Anxiety Depression Scale), quality (Spiegel's questionnaire). center pressure mean velocity was higher than condition eyes closed (p = 0.041, Hedges'g (g) 0.71). Women showed lower MoCA scores 0.028, g 1.06) as well NHPT duration 0.002, 1.64) (in dominant hand) DN4 0.003, 1.59) men. No significant found for remaining parameters. Based this study patients, poorer probably due their decline. These should be considered when organizing therapeutic training programs population.

Language: Английский

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Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1502 - 1502

Published: April 29, 2025

Pain is a significant global public health issue that can interfere with daily activities, sleep, and interpersonal relationships when it becomes chronic or worsens, ultimately impairing quality of life. Despite ongoing efforts, the efficacy pain treatments in improving outcomes for patients remains limited. At present, challenge lies developing personalized care management plan helps to maintain patient activity levels effectively manages pain. Neuropathic condition resulting from damage somatosensory nervous system, significantly impacting It partly thought be caused by inflammation oxidative stress, clinical research has suggested link between this diet. However, these links are not yet well understood require further investigation evaluate pathways involved neuropathic Specifically, question whether supplementation dietary antioxidants, such as melatonin, could serve potential adjunctive treatment modulation. Melatonin, primarily secreted pineal gland but also produced other systems digestive known its anti-inflammatory, antioxidant, anti-aging properties. found various fruits vegetables, presence alongside polyphenols foods may enhance melatonin intake contribute improved health. The aim review provide an overview examine role neuro-nutritional approach management.

Language: Английский

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Melatonin's paradox: From therapeutic benefits to toxicity warnings

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111556 - 111556

Published: May 1, 2025

Language: Английский

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