Food and Agricultural Immunology,
Journal Year:
2024,
Volume and Issue:
35(1)
Published: Dec. 3, 2024
Neurodegenerative
diseases
(NDDs)
affect
millions
of
lives
worldwide.
They
constitute
a
group
neurological
disorders
with
shared
common
features,
including
impaired
cognition,
behavior,
memory,
and
motor
functions.
These
conditions
arise
due
to
the
gradual
degeneration
neurons
within
nervous
system.
Even
though,
each
pathology
presents
diverse
etiologies
develops
in
different
brain
sites,
they
may
share
cellular
molecular
mechanisms,
such
as
inflammation,
protein
aggregation,
DNA
RNA
defects.
Heavy
metal
contamination
is
global
public
health
concern,
given
that
anthropogenic
activities
like
paint
manufacturing,
mining,
oil
refining
contribute
substantially
heavy
pollution.
Consequently,
studies
have
investigated
its
potential
etiological
factors
neurodegenerative
diseases.
This
review
examines
impact
dietary
exposure
metals,
specifically
mercury,
cadmium,
lead,
chromium,
arsenic,
zinc,
on
development
progression
Evidence
from
range
indicates
these
metals
play
significant
role
advancing
by
disrupting
essential
functions,
induction
oxidative
stress
impairments
mitochondrial
function.
findings
underscore
need
for
further
research
elucidate
toxicological
mechanisms
develop
preventive
strategies,
chelation
therapies
environmental
remediation.
Addressing
risks
especially
critical
protect
neurocognitive
health,
particularly
aging
populations.
Journal of Integrated Science and Technology,
Journal Year:
2025,
Volume and Issue:
13(3)
Published: Jan. 7, 2025
The
environmental
pollution
poses
a
serious
global
health
risk,
contributing
to
high
morbidity
and
mortality
rates.
Neurological
disorders,
such
as
Alzheimer's,
Parkinson's,
Schizophrenia,
ALS,
Huntington's
disease,
are
increasingly
prevalent
characterized
by
both
structural
functional
abnormalities
in
neurons
of
the
brain
spinal
cord.
Understanding
neuro-impact
toxins
is
crucial
for
developing
effective
prevention
intervention
strategies.
This
review
article
investigates
complex
interactions
between
neurological
health,
focusing
on
their
role
development
progression
neurodegenerative
neuropsychiatric
disorders.
Key
mechanisms
include
oxidative
stress,
mitochondrial
dysfunction,
and,
disruption
neurotransmitter
systems.
It
highlights
pathways
through
which
these
exert
effects,
presents
epidemiological
evidence
linking
toxin
exposure
discusses
potential
public
implications.
By
elucidating
connections,
paper
aims
enhance
understanding
determinants
health.
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 134 - 134
Published: Jan. 27, 2025
Heavy
metal
contamination
has
gradually
become
a
very
much
important
significant
global
issue
due
to
its
continual
existence
in
the
environment
and
bioaccumulation
ecosystems,
posing
deleterious
risks
human
health.
This
review
aims
investigate
sources,
pathways,
toxicological
impacts
of
heavy
metals
such
as
cadmium,
lead,
mercury,
arsenic,
elucidating
their
health
consequences
plausible
mitigation
strategies.
Furthermore,
explores
dual
origins
contamination;
natural
geological
processes
anthropogenic
activities
industrial
emissions,
mining,
agricultural
practices.
These
sip
into
soil,
water,
food
chains,
leading
bioaccumulation,
bio-magnification
causing
risks,
including
cardiovascular
diseases,
neurological
disorders,
reproductive
toxicity.
Additionally,
addition
indigenous
case
studies
from
Nigeria,
lead
poisoning
Zamfara
State
Great
Kwa
River
Cross
Rivers
underscores
disproportionate
impact
pollution
developing
nations.
reveal
socio-economic
environmental
dimensions
issue,
providing
contextual
understanding
region-specific
vulnerabilities
outcomes.
To
address
these
problems,
evaluates
already
existing
strategies,
chelation
therapy
phytoremediation,
while
proposing
sustainable,
cost-effective
solutions
for
reducing
exposure
mitigating
impacts.
It
emphasizes
importance
integrative
approaches
involving
policy,
community
engagement,
technological
innovations
fight
effectively.
In
conclusion,
this
seminar
contributes
toxicity,
giving
showcasing
insights
sources
implications
contamination.
By
integrating
theoretical
perspectives
with
practical
solutions,
provides
robust
framework
informing
policy
makers
advancing
sustainable
management
practices.
Hydrology,
Journal Year:
2025,
Volume and Issue:
12(2), P. 37 - 37
Published: Feb. 17, 2025
The
Santiago–Guadalajara
River
Basin
has
an
area
of
10,016.46
km2.
Metropolitan
Area
Guadalajara,
within
the
basin,
is
second-largest
city
in
country,
with
more
than
5
million
inhabitants.
growth
urban
population,
as
well
industrial
and
agricultural
activities
insufficient
infrastructure
for
sanitation
wastewater
its
reuse,
have
caused
environmental
deterioration
surface
waters
gradual
depletion
groundwater
resources.
To
assess
level
contamination
from
presence
heavy
metals
a
monthly
monitoring
campaign
was
carried
out
at
25
sampling
stations
located
main
tributary
streams
July
2021
to
April
2022.
following
decreasing
sequence
found
according
mean
concentration
values:
Fe
>
Al
Mn
B
Ba
Zn
As
Cu
Cr
Ni
Pb
Cd.
Heavy
Metal
Pollution
Index
(HPI)
method
applied
risk
aquatic
life,
finding
average
global
HPI
value
305.522
which
classifies
it
critical
range.
results
also
reflect
health
risks
due
As,
Cd,
some
monitored
stations.
It
will
be
necessary
expand
network,
identify
point
non-point
sources
contamination,
implement
measures
pollution
control
protect
life
human
river.
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 134 - 134
Published: Feb. 18, 2025
Heavy
metal
contamination
has
gradually
become
a
very
much
important
significant
global
issue
due
to
its
continual
existence
in
the
environment
and
bioaccumulation
ecosystems,
posing
deleterious
risks
human
health.
This
review
aims
investigate
sources,
pathways,
toxicological
impacts
of
heavy
metals
such
as
cadmium,
lead,
mercury,
arsenic,
elucidating
their
health
consequences
plausible
mitigation
strategies.
Furthermore,
explores
dual
origins
contamination;
natural
geological
processes
anthropogenic
activities
industrial
emissions,
mining,
agricultural
practices.
These
sip
into
soil,
water,
food
chains,
leading
bioaccumulation,
bio-magnification
causing
risks,
including
cardiovascular
diseases,
neurological
disorders,
reproductive
toxicity.
Additionally,
addition
indigenous
case
studies
from
Nigeria,
lead
poisoning
Zamfara
State
Great
Kwa
River
Cross
Rivers
underscores
disproportionate
impact
pollution
developing
nations.
reveal
socio-economic
environmental
dimensions
issue,
providing
contextual
understanding
region-specific
vulnerabilities
outcomes.
To
address
these
problems,
evaluates
already
existing
strategies,
chelation
therapy
phytoremediation,
while
proposing
sustainable,
cost-effective
solutions
for
reducing
exposure
mitigating
impacts.
It
emphasizes
importance
integrative
approaches
involving
policy,
community
engagement,
technological
innovations
fight
effectively.
In
conclusion,
this
seminar
contributes
toxicity,
giving
showcasing
insights
sources
implications
contamination.
By
integrating
theoretical
perspectives
with
practical
solutions,
provides
robust
framework
informing
policy
makers
advancing
sustainable
management
practices.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Mercury
(Hg)
exposure
is
a
possible
risk
factor
for
Alzheimer´s
disease
(AD),
and
some
studies
have
found
higher
Hg
levels
in
AD
patients.
Yet,
the
evidence
inconclusive,
mechanism
linking
to
neuropathology
remains
be
found.
The
hallmark
of
brains
deposits
insoluble
amyloid
plaques
consisting
mainly
aggregated
amyloid-β
(Aβ)
peptides.
Here,
we
use
transmission
electron
microscopy
(TEM)
biophysical
spectroscopy
techniques
study
in
vitro
interactions
between
inorganic
pathologically
relevant
Aβ(1-40)
Aβ(4-40)
variants
Aβ(1-40)(H6A,
H13A,
H14A)
mutant.
For
first
time,
effect
on
Aβ
aggregation
both
Hg(I)
Hg(II)
compared.
binds
with
an
apparent
binding
affinity
28±8
µM.
N-terminal
His6,
His13
His14
residues
are
involved
coordination.
induces
structural
alterations
(coil-coil
interactions)
monomers
positioned
membrane-mimicking
SDS
micelles.
Equimolar
amounts
either
or
inhibit
normal
fibrillation
by
directing
process
towards
formation
large
amorphous
aggregates.
All
these
rearrangements
may
harmful
processes
brain
pathology.
Inducing
protein
misfolding
might
general
toxic
mercury.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1194 - 1194
Published: Jan. 30, 2025
Multidrug
resistance
proteins
(MRPs)
are
transporters
for
metabolic
waste
and
xenobiotics
known
to
export
a
wide
range
of
substances
from
renal
tubular
cells.
This
study
aimed
define
characterize
the
transport
mercuric
conjugates
glutathione
(GSH-Hg-GSH)
in
inside-out
membrane
vesicles
containing
MRP3
MPR5.
The
functionality
MRP5
was
confirmed
by
measuring
uptake
[3H]-estradiol
5-6-carboxy-2′,7′-dichloro-fluorescein
(CDCF)
over
time
(at
1,
5,
15,
30
min).
GSH-Hg-GSH,
radioactive
mercury
([203Hg]),
measured
each
set
time,
findings
suggest
that
GSH-Hg-GSH
is
substrate
MRP5.
saturation
kinetics
were
also
analyzed
10
µM
GSH-[203Hg]-GSH
presence
25,
50,
or
100
unlabeled
5
min
at
37
°C.
(Vmax
=
25.6
µM;
Km
2.8
µM)
32.9
4.9
saturable.
These
first
show
capable
mediating
any
form
mercury.
The Journal of Physical Chemistry Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 12129 - 12137
Published: Nov. 27, 2024
It
is
a
critical
and
broad
prospect
to
evaluate
ion
levels
monitor
their
dynamic
changes
in
the
brain
for
early
diagnosis,
in-depth
mechanism
investigation,
accurate
staging
of
neurodegenerative
diseases
including
Alzheimer's
disease
(AD).
still
great
challenge
vivo
track
Zn
