The Role of Basolateral Amygdala and Medial Prefrontal Cortex in Fear: A Systematic Review DOI Open Access
Volodymyr Mavrych,

Fathima Riyas,

Olena Bolgova

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Fear is a primary adaptive response to potential threats. It triggers complex cascade of physiological, cognitive, and behavioral changes that prepare an organism cope with dangerous situations. The basolateral amygdala (BLA) medial prefrontal cortex (mPFC) are both linked adaptation, the generation strong emotions, decision-making. In this systematic review, we aimed analyze recent studies connections between BLA mPFC in context their neuroanatomy, cellular composition, micro-circuitry, involvement fear. Utilizing Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) 2020 guidelines, our search strategy involved scouring articles from PubMed (National Center Biotechnology Information, Bethesda, Maryland), Google Scholar (Google, Mountain View, CA), Science Direct (Elsevier, Amsterdam, Netherlands) databases covering last decade (2014-2024). Thirty-two rigorously evaluated formed essence review. Review findings revealed bidirectional connectivity mPFC, distinct roles different subregions. rostral primarily projects prelimbic cortex, while caudal connects infralimbic cortex. These circuits show specialized containing principal excitatory neurons GABAergic interneurons, exhibits layer-specific synaptic connections. processing involves dynamic interactions these regions, promoting fear expression facilitating extinction. analysis showed astrocytic signaling N-methyl-D-aspartate (NMDA) receptor activation essential process memory formation its There was evidence dysregulation specific associated pathophysiology several other psychiatric disorders, such as post-traumatic stress disorder (PTSD), anxiety schizophrenia. This review clarifies BLA-mPFC circuitry critical perceiving regulation. results highlight importance brain regions types cells each region respond appropriately Uncovering type further helps understand mechanisms fear-associated disorders may suggest treatment options. Future research should focus on plasticity mechanisms, translational applications, influence individual factors develop more effective treatments conditions involving dysregulation.

Language: Английский

The Role of Basolateral Amygdala and Medial Prefrontal Cortex in Fear: A Systematic Review DOI Open Access
Volodymyr Mavrych,

Fathima Riyas,

Olena Bolgova

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Fear is a primary adaptive response to potential threats. It triggers complex cascade of physiological, cognitive, and behavioral changes that prepare an organism cope with dangerous situations. The basolateral amygdala (BLA) medial prefrontal cortex (mPFC) are both linked adaptation, the generation strong emotions, decision-making. In this systematic review, we aimed analyze recent studies connections between BLA mPFC in context their neuroanatomy, cellular composition, micro-circuitry, involvement fear. Utilizing Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) 2020 guidelines, our search strategy involved scouring articles from PubMed (National Center Biotechnology Information, Bethesda, Maryland), Google Scholar (Google, Mountain View, CA), Science Direct (Elsevier, Amsterdam, Netherlands) databases covering last decade (2014-2024). Thirty-two rigorously evaluated formed essence review. Review findings revealed bidirectional connectivity mPFC, distinct roles different subregions. rostral primarily projects prelimbic cortex, while caudal connects infralimbic cortex. These circuits show specialized containing principal excitatory neurons GABAergic interneurons, exhibits layer-specific synaptic connections. processing involves dynamic interactions these regions, promoting fear expression facilitating extinction. analysis showed astrocytic signaling N-methyl-D-aspartate (NMDA) receptor activation essential process memory formation its There was evidence dysregulation specific associated pathophysiology several other psychiatric disorders, such as post-traumatic stress disorder (PTSD), anxiety schizophrenia. This review clarifies BLA-mPFC circuitry critical perceiving regulation. results highlight importance brain regions types cells each region respond appropriately Uncovering type further helps understand mechanisms fear-associated disorders may suggest treatment options. Future research should focus on plasticity mechanisms, translational applications, influence individual factors develop more effective treatments conditions involving dysregulation.

Language: Английский

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