The multifaceted role of ferroptosis in liver disease DOI Creative Commons
Junyi Chen, Xiaopeng Li, Chaodong Ge

et al.

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: 29(3), P. 467 - 480

Published: Jan. 24, 2022

Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and associated with a plethora pathological conditions in the liver. Emerging evidence supports notion that dysregulated metabolic pathways impaired iron homeostasis play role progression liver disease via ferroptosis. Although molecular mechanisms which ferroptosis causes are poorly understood, several ferroptosis-associated genes have been implicated disease. Here, we review physiological processing nutrients, our current understanding metabolism, characteristics ferroptosis, regulate In addition, summarize pathogenesis disease, including injury, non-alcoholic steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinoma. Finally, discuss therapeutic potential targeting for managing

Language: Английский

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease DOI Creative Commons
Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayır

et al.

Cell, Journal Year: 2017, Volume and Issue: 171(2), P. 273 - 285

Published: Oct. 1, 2017

Language: Английский

Citations

5504
Targeting Ferroptosis to Iron Out Cancer DOI Creative Commons

Behrouz Hassannia,

Peter Vandenabeele, Tom Vanden Berghe

et al.

Cancer Cell, Journal Year: 2019, Volume and Issue: 35(6), P. 830 - 849

Published: May 16, 2019

Language: Английский

Citations

1952
Targeting ferroptosis as a vulnerability in cancer DOI
Guang Lei, Li Zhuang, Boyi Gan

et al.

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(7), P. 381 - 396

Published: March 25, 2022

Language: Английский

Citations

1417
Recent Progress in Ferroptosis Inducers for Cancer Therapy DOI
Chen Liang, Xinglin Zhang, Mengsu Yang

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Oct. 8, 2019

Abstract Ferroptosis is a newly discovered form of regulated cell death that the nexus between metabolism, redox biology, and human health. Emerging evidence shows potential triggering ferroptosis for cancer therapy, particularly eradicating aggressive malignancies are resistant to traditional therapies. Recently, there has been great deal effort design develop anticancer drugs based on induction. Recent advances ferroptosis‐inducing agents at intersection chemistry, materials science, biology presented. The basis summarized first highlight feasibility characteristics therapy. A literature review inducers (including small molecules nanomaterials) then presented delineate their design, action mechanisms, applications. Finally, some considerations research spotlighted, followed by discussion challenges future development directions this burgeoning field.

Language: Английский

Citations

1271
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases DOI Creative Commons
Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew

et al.

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Oct. 16, 2018

Aging is the progressive loss of organ and tissue function over time. Growing older positively linked to cognitive biological degeneration such as physical frailty, psychological impairment, decline. Oxidative stress considered an imbalance between pro- antioxidant species, which results in molecular cellular damage. plays a crucial role development age-related diseases. Emerging research evidence has suggested that can control autoxidation by interrupting propagation free radicals or inhibiting formation subsequently reduce oxidative stress, improve immune function, increase healthy longevity. Indeed, oxidation damage highly dependent on inherited acquired defects enzymes involved redox-mediated signaling pathways. Therefore, molecules with activity promote aging counteract worth discuss further. Of particular interest this article, we highlighted mechanisms antioxidants prevention Taken together, better understanding redox modulation inflammation would provide useful approach for potential interventions, promoting

Language: Английский

Citations

975
Neuronal Cell Death DOI Open Access
Michael Fricker, Aviva M. Tolkovsky, Vilmantė Borutaitė

et al.

Physiological Reviews, Journal Year: 2018, Volume and Issue: 98(2), P. 813 - 880

Published: Feb. 28, 2018

Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity adult neurons to proliferate or be replaced. The concept used simple as there were just two three types, so we had work out which type was involved in our particular pathology then block it. However, now know that are at least a dozen ways for die, blocking mechanism may not prevent from dying, non-neuronal cells also contribute neuronal death. We review here mechanisms by intrinsic extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, mitochondrial permeability transition. next explore development, those induced axotomy, aberrant cell-cycle reentry, glutamate (excitoxicity oxytosis), loss connected neurons, aggregated proteins unfolded protein response, oxidants, inflammation, microglia. reassess forms occur stroke Alzheimer’s disease, most pathologies involving discuss why has been difficult pinpoint involved, if matters, molecular overlap interplay between subroutines, therapeutic implications these multiple overlapping

Language: Английский

Citations

926
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death DOI Creative Commons
Omkar Zilka, Ron Shah, Bo Li

et al.

ACS Central Science, Journal Year: 2017, Volume and Issue: 3(3), P. 232 - 243

Published: March 7, 2017

Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation lipid hydroperoxides that may play key role in pathogenesis degenerative diseases which peroxidation has been implicated. High-throughput screening efforts have identified ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1) as potent inhibitors ferroptosis − an activity ascribed to their ability slow hydroperoxides. Herein we demonstrate this likely derives from reactivity radical-trapping antioxidants (RTAs) rather than potency lipoxygenases. Although inhibited autoxidations styrene revealed Fer-1 Lip-1 react roughly 10-fold more slowly peroxyl radicals reactions α-tocopherol (α-TOH), they were significantly reactive α-TOH phosphatidylcholine bilayers consistent greater relative ferroptosis. None Fer-1, Lip-1, human 15-lipoxygenase-1 (15-LOX-1) overexpressed HEK-293 cells when assayed at concentrations where These results stand stark contrast those obtained known 15-LOX-1 inhibitor (PD146176), was able inhibit enzyme it effective inhibiting Given likelihood subvert by RTAs, evaluated antiferroptotic potential 1,8-tetrahydronaphthyridinols (hereafter THNs): rationally designed unparalleled reactivity. We show for first time inherent THNs translates cell culture, lipophilic similarly subverting induced either pharmacological or genetic inhibition hydroperoxide-detoxifying Gpx4 mouse fibroblasts, glutamate-induced death hippocampal cells. RTAs suggest (autoxidation) central process.

Language: Английский

Citations

774
GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis DOI
Giovanni C. Forcina, Scott J. Dixon

PROTEOMICS, Journal Year: 2019, Volume and Issue: 19(18)

Published: March 20, 2019

Abstract Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation cholesterol phospholipids containing polyunsaturated fatty acyl chains lead to lipid peroxidation, membrane damage, cell death. Lipid hydroperoxides are key intermediates in process peroxidation. The hydroperoxidase glutathione peroxidase 4 (GPX4) converts alcohols, this prevents iron (Fe 2+ )‐dependent formation toxic reactive oxygen species (ROS). Inhibition GPX4 function leads peroxidation result induction ferroptosis, an iron‐dependent, non‐apoptotic form This review describes species, preventing oxidative link between dysfunction, oxidation, ferroptosis.

Language: Английский

Citations

754
The metabolism of cancer cells during metastasis DOI
Gabriele Bergers, Sarah‐Maria Fendt

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(3), P. 162 - 180

Published: Jan. 18, 2021

Language: Английский

Citations

669
Microbial lipases and their industrial applications: a comprehensive review DOI Creative Commons
Prem Chandra,

Enespa,

Ranjan Singh

et al.

Microbial Cell Factories, Journal Year: 2020, Volume and Issue: 19(1)

Published: Aug. 26, 2020

Lipases are very versatile enzymes, and produced the attention of several industrial processes. Lipase can be achieved from sources, animal, vegetable, microbiological. The uses microbial lipase market is estimated to USD 425.0 Million in 2018 it projected reach 590.2 by 2023, growing at a CAGR 6.8% 2018. Microbial lipases (EC 3.1.1.3) catalyze hydrolysis long chain triglycerides. origins enzymes logically dynamic proficient also have an extensive range with manufacturing altered molecules. unique (triacylglycerol acyl hydrolase) catalyzed hydrolysis, esterification alcoholysis reactions. Immobilization has made use accomplish its best performance hence suitable for reactions need enhance aroma immobilization Immobilized depend on technique carrier type. choice concerns usually biocompatibility, chemical thermal stability, insolubility under reaction conditions, capability easy rejuvenation reusability, as well cost proficiency. Bacillus spp., Achromobacter Alcaligenes Arthrobacter Pseudomonos bacteria Penicillium Fusarium Aspergillus fungi screened large scale production. multipurpose biological catalyst given favorable vision meeting needs industries such biodiesel, foods drinks, leather, textile, detergents, pharmaceuticals medicals. This review represents discussion sources lipases, methods increased productivity profitability reduce logistical liability environment user.

Language: Английский

Citations

667