Cited by The significant roles of ferroptosis and lactylation in pathogenesis and treatment of osteoporosis-insights from a bibliometric analysis

The role of lactate metabolism and lactylation in pulmonary arterial hypertension DOI

Tao Peng,

Jian-Liang Lu,

Xiaojiao Zheng

et al.

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 12, 2025

Pulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by elevated pulmonary artery pressure vascular remodeling. Recent studies have underscored the pivotal role of metabolic dysregulation epigenetic modifications in pathogenesis PAH. Lactate, byproduct glycolysis, now recognized as key molecule that links cellular metabolism with activity regulation. findings indicate that, addition to altered glycolytic dysregulated. Lactate homeostasis lactylation—a novel modification—also play significant development This review synthesizes current knowledge regarding relationship between PAH, particular focus on cumulative effects lactate cells. Furthermore, lactylation, an emerging modification, discussed context By elucidating interplay lactylation this aims provide insights into potential therapeutic targets. Understanding these pathways may lead innovative strategies for managing PAH improving patient outcomes. Future research should underlying mechanisms through which influences pathophysiology thereby aiding targeted interventions.

Language: Английский

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Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases DOI

Min Zhou, Zihao Qin,

Xiting Zhu

et al.

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

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METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2 DOI

Jinyu Zhou, Rui Wang, Zequn Zhang

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 25, 2025

Abstract Ossification of the ligamentum flavum (OLF) is characterized by thickening and subsequent thoracic canal stenosis. Emerging evidence has demonstrated involvement N6-methyladenosine (m6A) methylation in OLF pathogenesis. This study investigates regulatory role METTL3-mediated m6A BMP2 progression. Clinical tissues were analyzed for levels using dot blot analysis. Osteogenic differentiation was assessed through quantitative real-time PCR (qPCR), alkaline phosphatase staining, alizarin red S western Mechanistic insights obtained methylated RNA immunoprecipitation (MeRIP), (RIP), luciferase reporter assays. The histone lactylation on METTL3 expression examined LDHA knockdown, sodium lactate (Nala) treatment, 2-deoxy-D-glucose (2-DG) administration cells. Our findings revealed significant upregulation patients. shown to enhance osteogenic BMP2, which specifically recognized IGF2BP1. Furthermore, increased observed patients, with enrichment promoter region facilitating its transcriptional activation. knockdown-mediated inhibition endogenous suppressed differentiation, a phenotype that rescued overexpression. In conclusion, this elucidates lactylation-mediated promotes progression IGF2BP1-dependent providing novel into potential therapeutic strategies management.

Language: Английский

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H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells DOI

Xiaomin Xie,

Chaowei Wen, Quekun Peng

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 499, P. 117347 - 117347

Published: April 16, 2025

Language: Английский

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The significant roles of ferroptosis and lactylation in pathogenesis and treatment of osteoporosis-insights from a bibliometric analysis DOI

Peng Yin, Xuguang Liu, Zhihe Zhao

et al.

Asian Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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