Endoplasmic reticulum stress in the pathogenesis of chemotherapy‐induced mucositis: Physiological mechanisms and therapeutic implications

Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(8)

Published: June 14, 2024

Chemotherapy is a common and effective treatment for cancer, but these drugs are also associated with significant side effects affecting patients' well-being. One such debilitating effect mucositis, characterized by inflammation, ulcerations, altered physiological functions of the gastrointestinal (GI) tract's mucosal lining. Understanding mechanisms chemotherapy-induced intestinal mucositis (CIM) crucial developing preventive measures supportive care. Chemotherapeutics not only target cancer cells rapidly dividing in GI tract. These disrupt endoplasmic reticulum (ER) homeostasis, leading to ER-stress activation unfolded protein response (UPR) various epithelial cell types. The UPR triggers signaling pathways that exacerbate tissue inflammation damage, influence differentiation fate cells, compromise integrity barrier. factors contribute significantly development progression. In this review, we aim give an in-depth overview role its impact on function. This will provide valuable insights into underlying highlighting potential therapeutic interventions could improve treatment-outcomes quality life patients.

Language: Английский

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Spatial Transcriptomics Delineates Potential Differences in Intestinal Phenotypes of Cardiac and Classical Necrotizing Enterocolitis

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112166 - 112166

Published: March 7, 2025

Necrotizing enterocolitis (NEC) is a devastating neonatal gastrointestinal disease, often resulting in multi-organ failure and death. While classical NEC strictly associated with prematurity, cardiac subset of the disease occurring infants comorbid congenital heart disease. Despite similar symptomatology, subtypes vary slightly presentation may represent etiologically distinct diseases. We compared ileal spatial transcriptomes patients NEC. Epithelial immune cells cluster well by cell-type segment subtype. Differences metabolism cell activation functionally differentiate makeup subtypes. The phenotype defined dysbiosis-induced inflammatory signaling metabolic acidosis, while that involves reduced angiogenesis endoplasmic reticulum stress-induced apoptosis. subtype-associated clinical demographic variability, transcriptomics has substantiated pathway network differences within epithelial segments between

Language: Английский

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Endoplasmic reticulum stress in acute lung injury and pulmonary fibrosis

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(23)

Published: Dec. 9, 2024

Abstract Pulmonary fibrosis (PF) is a progressive and irreversible lung disease that leads to diminished function, respiratory failure, ultimately death typically has poor prognosis, with an average survival time of 2 5 years. Related articles suggested endoplasmic reticulum (ER) stress played critical role in the occurrence progression PF. The ER responsible for maintaining protein homeostasis. However, factors such as aging, hypoxia, oxidative stress, or inflammation can disrupt this balance, promoting accumulation misfolded proteins triggering stress. To cope situation, cells activate unfolded response (UPR). Since acute injury (ALI) one key onset events PF, review, we will discuss ALI PF by activating multiple signaling pathways molecular mechanisms affect function behavior different cell types, focus on epithelial cells, fibroblasts, macrophages. Linking these types may broaden our understanding underlying help us target through mechanisms. relationship between still evolving, future research explore new strategies regulate UPR pathways, providing novel therapeutic targets.

Language: Английский

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Hypoxia-inducible factor-1α as a biomarker for individuals under hypoxia duration and pattern in fat greenling Hexagrammos otakii

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 39, P. 102459 - 102459

Published: Oct. 31, 2024

Language: Английский

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