The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function DOI Creative Commons
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter‐loaded vesicles during activity, at the same time as also controlling local concentrations numerous exo‐ and endocytosis cofactors. In addition, SVC hosts molecules that participate in other aspects function, from cytoskeletal components to adhesion proteins, affects location function organelles such mitochondria endoplasmic reticulum. We argue here these features extend functional involvement synapse formation, signalling plasticity, well stabilization metabolism. propose changes size coalesce with postsynaptic compartment, supporting interplay between pre‐ dynamics. Thereby, could be seen ‘all‐in‐one’ regulator structure should investigated more detail, reveal molecular mechanisms control heterogeneity. image

Language: Английский

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function DOI Creative Commons
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter‐loaded vesicles during activity, at the same time as also controlling local concentrations numerous exo‐ and endocytosis cofactors. In addition, SVC hosts molecules that participate in other aspects function, from cytoskeletal components to adhesion proteins, affects location function organelles such mitochondria endoplasmic reticulum. We argue here these features extend functional involvement synapse formation, signalling plasticity, well stabilization metabolism. propose changes size coalesce with postsynaptic compartment, supporting interplay between pre‐ dynamics. Thereby, could be seen ‘all‐in‐one’ regulator structure should investigated more detail, reveal molecular mechanisms control heterogeneity. image

Language: Английский

Citations

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