3D Printed Multifunctional Bioadhesive Patch with Intrinsic Bioelectronic Properties for Decoding Electromechanical and Anisotropic Cardiac Microenvironment DOI Open Access
Sayan Deb Dutta, Tejal V. Patil, Ki‐Taek Lim

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 6, 2024

ABSTRACT Fabricating anisotropic multifunctional bioadhesive patches with tunable mechanical stiffness, electrical conductivity, antimicrobial activity, and modulating cellular behavior is crucial for the successful management of cardiac tissue injury boosting immunogenic microenvironments. Direct ink writing (DIW)-based 3D printing holds tremendous potential developing electroactive (ECPs) microarchitecture. Inspired by native myocardium, we developed a ECP stiffness incorporating highly conductive graphene oxide/nanodiamond (GO@ND) complex into biocompatible carboxymethyl chitosan/polyvinyl alcohol (CSA) matrix regulating cardiomyogenic cues. The incorporation GO@ND enhanced conductivity (∼22.6 S mm -1 ) high interfacial toughness (>250 MJ m improved printability ( n = 0.5) concentration-dependent self-assembly CSA matrix. We observed that stimulation (EFs; 250 mV/20 min/day) through nanoengineered resulted in broad-spectrum antibacterial activity against E. coli S. aureus 99.29% 98.74%, respectively, via sustained release curcumin (Cur). Moreover, electromechanical study revealed higher (∼6.2 kPa) activated cytoplasmic YAPs during macrophage polarization. Besides, EFs regulated human cardiomyocyte differentiation force-driven early activation Vinculin, triggering phosphorylation NFATc3 activating Lamin A/C YAP-dependent manner. Based on these findings, anticipated fabricated patch had electro-cardiomyogenic microenvironment abilities.

Language: Английский

Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair DOI

Qiang Lv,

Dandan Zhou, Yutong He

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 172 - 192

Published: March 9, 2025

Language: Английский

Citations

0
From innovation to clinic: emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair DOI Creative Commons
Rajiv Borah,

Daniel Clarke,

Jnanendra Upadhyay

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101415 - 101415

Published: Dec. 19, 2024

Language: Английский

Citations

3
Intra or extracellular: The location of piezotronic effect determines the polarization regulation of macrophages for enhanced wound healing DOI

Bo‐Jun Xie,

Shan Lu, Liang Wang

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110893 - 110893

Published: March 1, 2025

Language: Английский

Citations

0
Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing DOI Creative Commons

Yang Zhang,

Zhiyuan Zheng,

Shilu Zhu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract The incidence and burden of skin wounds, especially chronic complex have a profound impact on healthcare. Effective wound healing strategies require multidisciplinary approach, advances in materials science bioengineering paved the way for development novel dressing. In this context, electrospun nanofibers can mimic architecture natural extracellular matrix provide new opportunities healing. Inspired by bioelectric phenomena human body, nanofibrous scaffolds with electroactive characteristics are gaining widespread attention gradually emerging. To end, review first summarizes basic process healing, causes current status clinical treatment, highlighting urgency importance dressings. Then, biological effects electric fields, preparation materials, manufacturing techniques (EEN) discussed. latest progress EEN enhancing is systematically reviewed, mainly including treatment monitoring. Finally, scaffold to enhance emphasized, challenges prospects summarized.

Language: Английский

Citations

0
3D Printed Multifunctional Bioadhesive Patch with Intrinsic Bioelectronic Properties for Decoding Electromechanical and Anisotropic Cardiac Microenvironment DOI Open Access
Sayan Deb Dutta, Tejal V. Patil, Ki‐Taek Lim

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 6, 2024

ABSTRACT Fabricating anisotropic multifunctional bioadhesive patches with tunable mechanical stiffness, electrical conductivity, antimicrobial activity, and modulating cellular behavior is crucial for the successful management of cardiac tissue injury boosting immunogenic microenvironments. Direct ink writing (DIW)-based 3D printing holds tremendous potential developing electroactive (ECPs) microarchitecture. Inspired by native myocardium, we developed a ECP stiffness incorporating highly conductive graphene oxide/nanodiamond (GO@ND) complex into biocompatible carboxymethyl chitosan/polyvinyl alcohol (CSA) matrix regulating cardiomyogenic cues. The incorporation GO@ND enhanced conductivity (∼22.6 S mm -1 ) high interfacial toughness (>250 MJ m improved printability ( n = 0.5) concentration-dependent self-assembly CSA matrix. We observed that stimulation (EFs; 250 mV/20 min/day) through nanoengineered resulted in broad-spectrum antibacterial activity against E. coli S. aureus 99.29% 98.74%, respectively, via sustained release curcumin (Cur). Moreover, electromechanical study revealed higher (∼6.2 kPa) activated cytoplasmic YAPs during macrophage polarization. Besides, EFs regulated human cardiomyocyte differentiation force-driven early activation Vinculin, triggering phosphorylation NFATc3 activating Lamin A/C YAP-dependent manner. Based on these findings, anticipated fabricated patch had electro-cardiomyogenic microenvironment abilities.

Language: Английский

Citations

0