Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result exercise or physical activity general. The importance this phenomenon is currently studied terms impact exercise- -induced signaling factors have, interaction "muscle-brain crosstalk." So far, muscle-derived myokines were demonstrated to intercede connection between and plethora various organs such adipose tissue, liver, pancreas. However, exact mechanism muscle-brain communication yet determined. It speculated that, particular, brain-derived neurotrophic factor (BDNF), irisin, cathepsin B (CTSB), interleukin 6 (IL-6), insulin-like growth factor-1 (IGF-1) partake crosstalk by promoting neuronal proliferation synaptic plasticity, also resulting improved cognition ameliorated behavioral alterations. Researchers suggest act directly on brain parenchyma via crossing blood-brain barrier (BBB). following article reviews information available regarding rodent studies main determined cross BBB, specifically addressing association exercise-induced myokine release central nervous system (CNS) impairments. Although hypothesis being critical sources seems promising, should not forgotten origin these vary, depending cell types their synthesis. Limited amount research providing alterations expression at same time, results taking them only circumstantial evidence way determine actual involvement overall state homeostasis. CNS

Language: Английский