Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability DOI Creative Commons

Tianyi Lyu,

Haonan Qian,

Sung-Pil Chung

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1071 - 1071

Published: Oct. 27, 2024

Objective: This study aimed to investigate the potential associations between physical activity, sedentary behavior, and basal metabolic rate (BMR) with post-traumatic stress disorder (PTSD), major depressive (MDD), emotional instability (EI) using bidirectional Mendelian randomization (MR). Additionally, it sought identify key molecular mechanisms underlying through a comprehensive bioinformatic analysis. Methods: MR analyses utilizing genome-wide association (GWAS) data were conducted estimate effects of BMR on PTSD, MDD, EI. Sensitivity performed assess robustness findings. Concurrently, analysis was executed gene expression datasets (GSE53987 GSE21138) derived from emotionally unstable patients. encompassed differential differentially expressed genes (DEGs), followed by an functional enrichment uncover pathways associated Results: The revealed that increased activity may have protective effect against albeit inconsistent MDD Sedentary behavior demonstrated minimal or identified 114 DEGs EI, YWHAB, SRRM2, MST1, HDAC10, HSPA1A highlighted as significant genes. these unveiled potentially involved in pathology instability. Conclusions: Physical appears protect whereas its EI are less definitive. findings offer deeper understanding pinpointing specific serve therapeutic targets. Further research is warranted elucidate intricate interactions mechanisms.

Language: Английский

Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit DOI Creative Commons
Guo Tang, T. Zhang, Ping Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 27, 2025

Language: Английский

Citations

0
Tannic acid-copper (II) complex-loaded nanoemulsion as a potential treatment for neuropsychiatric disorders DOI

R. Saraiva,

Matheus da Silva Campelo,

Thaís Araújo Gomes Ferreira

et al.

Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138189 - 138189

Published: Feb. 1, 2025

Language: Английский

Citations

0
Lipopolysaccharide-Induced Inflammatory Response and Its Prominent Suppression by Paspalum thunbergii Extract DOI Open Access

Bin Ha,

Ji-Hye Kang,

Do Hyun Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1611 - 1611

Published: Feb. 13, 2025

The extract of Paspalum thunbergii, a native perennial herb in Korea belonging to the rice family, was investigated for its anti-inflammatory activity and underlying mechanisms driving effects. Fifteen chemical components P. thunbergii extract, including rosmarinic acid isoquercitrin, were identified using LC-MS. showed antioxidative through DPPH ABTS cation radical scavenging activity. significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production macrophage RAW 264.7 cells. expression lipopolysaccharide-induced iNOS COX-2, which are inflammation-related enzymes. To explore mechanism, levels signal proteins related MAPK, NF-κB, JAK/STAT, Wnt/β-catenin signaling measured. As result, p-p38, p-JNK increased by LPS Additionally, it decreased LPS-induced p-IKKβ p-NF-κB p65 prevented migration into nucleus caused LPS. Notably, p-JAK1, p-STAT3, Wnt 3α, β-catenin, p-GSK-3β protein expressions also inhibited. Therefore, prominent may be via pathway.

Language: Английский

Citations

0
One-pot Multicomponent Tandem Reaction for the Rapid Synthesis of 2-Amino-3-benzylindoles DOI
Pengyan Zhang, Chenrui Liu,

Maoyi Dai

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel one-pot oxidative cross-dehydrogenation coupling (CDC) reaction has been developed for the selective construction of C–N and C–C bonds at C2,3-positions indoles.

Language: Английский

Citations

0
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction DOI
Manpreet Kaur,

Pratyush Porel,

Ronak Y. Patel

et al.

Neurotoxicity Research, Journal Year: 2025, Volume and Issue: 43(2)

Published: March 28, 2025

Language: Английский

Citations

0
Sleep Disturbances in Generalized Anxiety Disorder: The Central Role of Insomnia DOI
Yan Xue, Wei-dong Wang,

Yanjiao Liu

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 132, P. 106545 - 106545

Published: April 29, 2025

Language: Английский

Citations

0
Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability DOI Creative Commons

Tianyi Lyu,

Haonan Qian,

Sung-Pil Chung

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1071 - 1071

Published: Oct. 27, 2024

Objective: This study aimed to investigate the potential associations between physical activity, sedentary behavior, and basal metabolic rate (BMR) with post-traumatic stress disorder (PTSD), major depressive (MDD), emotional instability (EI) using bidirectional Mendelian randomization (MR). Additionally, it sought identify key molecular mechanisms underlying through a comprehensive bioinformatic analysis. Methods: MR analyses utilizing genome-wide association (GWAS) data were conducted estimate effects of BMR on PTSD, MDD, EI. Sensitivity performed assess robustness findings. Concurrently, analysis was executed gene expression datasets (GSE53987 GSE21138) derived from emotionally unstable patients. encompassed differential differentially expressed genes (DEGs), followed by an functional enrichment uncover pathways associated Results: The revealed that increased activity may have protective effect against albeit inconsistent MDD Sedentary behavior demonstrated minimal or identified 114 DEGs EI, YWHAB, SRRM2, MST1, HDAC10, HSPA1A highlighted as significant genes. these unveiled potentially involved in pathology instability. Conclusions: Physical appears protect whereas its EI are less definitive. findings offer deeper understanding pinpointing specific serve therapeutic targets. Further research is warranted elucidate intricate interactions mechanisms.

Language: Английский

Citations

0