Basal Xenobot transcriptomics reveals changes and novel control modality in cells freed from organismal influence

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 22, 2025

Abstract Would transcriptomes change if cell collectives acquired a novel morphogenetic and behavioral phenotype in the absence of genomic editing, transgenes, heterologous materials, or drugs? We investigate effects morphology nascent emergent life history on gene expression basal (no engineering, no sculpting) form Xenobots —autonomously motile constructs derived from Xenopus embryo ectodermal explants. To differences between cells context an with those that have been freed instructive signals lived experiences, we compare these age-matched embryos. Basal show significantly larger inter-individual variability than embryos, suggesting increased exploration transcriptional space. identify at least 537 (non-epidermal) transcripts uniquely upregulated Xenobots. Phylostratigraphy shows majority transcriptomic shifts towards evolutionarily ancient transcripts. Pathway analyses indicate categories motility machinery, multicellularity, stress immune response, metabolism, thanatotranscriptome, sensory perception sound mechanical stimuli. experimentally confirm respond to acoustic stimuli via changes behavior. Together, data may implications for evolution, biomedicine, synthetic morphoengineering.

Language: Английский

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Xenobot Transcriptomics: Gene Expression Changes in wild-type cells forming a synthetic biobot

Published: Aug. 30, 2024

The standard paradigm of developmental and synthetic biology focuses on gene expression driving changes in morphology. Here, we investigated the reverse relationship: would transcriptomes change if cell collectives acquired a novel morphogenetic behavioral phenotype absence genomic editing, transgenes, heterologous materials, or drugs? We effects morphology nascent emergent life history basal (no engineering, no sculpting) form Xenobots – autonomously motile constructs derived from Xenopus embryo ectodermal explants. compared these with age-matched embryos. These showed significantly larger inter-individual variability than embryos, suggesting increased exploration transcriptional space. identified at least 537 (non-epidermal) transcripts uniquely upregulated Xenobots. Pathway analyses indicated shifts categories motility machinery, pattern formation multicellularity, stress immune response, metabolism, sensory perception sound mechanical stimuli. Phylostratigraphic analysis that majority transcriptomic were towards evolutionarily ancient systems. Lastly, found enrichment thanatotranscriptomic genes, shedding light distinction between death an organism its cells. data relationship genotype may have implications for evolution, biomedicine, morphoengineering.

Language: Английский

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Biological life is more than physics: Expanding our scientific worldview may be critical for securing the Earth-life system

Published: Aug. 25, 2024

The future of humanity and the environment are intertwined. Our collective growth shapes disrupts environmental systems at planetary-scale. We pursue increasingly technological futures, while warning need to repair natural biosphere that sustain us. Facing globally interconnected challenges, scientific approaches guide our decision-making have never been more important for informing future. Physicalist (physical-only), reductionistic worldviews, which strive eliminate subjectivity, provide conceptual framing mainstream views purport completely frame describe biological life. However, we observe ample case studies from biology, ecology, human health, animal behavior, other life sciences where course events shaped by intrinsic cognitive subjective assessments benefits drawbacks. It is argued such perceptions, adaptive goal-directed behaviors, represent an overlooked non-material facet or dimension, linked bioelectric read/write/compute capacity, critical organism-, ecosystem-, biosphere-scales.

Language: Английский

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Research on cognitive computing model based on machine learning algorithm in artificial intelligence environment

Applied Mathematics and Nonlinear Sciences, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract In the artificial intelligence environment, constructing cognitive computational models using machine learning algorithms is main direction of computer development. By outlining three levels learning, feature space composition model exposed based on data acquired by human brain monitoring equipment. The Gaussian decision tree algorithm used to construct computation model, and anthropomorphic effects are explored in two directions: auditory features visual features. terms features, this paper maintains 95.03% ± 2.49% recognition rate. contrast, proposed a high tracking success rate 88.83%. Based analysis results, computing has been confirmed perform excellently.

Language: Английский

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Cognitive Glues Are Shared Models of Relative Scarcities: The Economics of Collective Intelligence

Published: Nov. 7, 2024

Collective intelligence refers to emergent problem-solving capacities that are different than those of the system’s subunits. Due plethora multi-scale systems within nature and society, it is imperative understand interaction policies necessary sufficient for subunits form collective intelligences. The economy a complex system consisting autonomous elements at multiple scales which exhibits adaptive capabilities, suggesting offers an interesting important example intelligence. We identify price as cognitive glue works coordinate by acting affordance allows members use plans mutually compatible with every other member economy. Using existing framework Watson Levin [1] we elaborate on various aspects make useful model argue any must solve same kind problem solves in broadly way it, thus serves generic template or abstract all glues. Finally, describe some research ideas combine concepts from biology economics hopes inspiring interdisciplinary collaboration.

Language: Английский

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The biophysics of balanced living: a mechano-homeostasis paradigm for balancing in animals and robots

Published: Dec. 14, 2024

From birth until death animals resist gravity, effortfully asserting bodily form, animate behaviour, and postural balance. Most basic negentropic behaviours are understood as homeostasis (e.g. thermoregulation), but balance is taken to be an exception. Many studies have elucidated its sub-mechanisms, the existence of goal-oriented homeostatic organisation remains open question. The current theoretical paper reviews existing work highlight challenge assumptions that belie a model, arguing organised one aspect wider mechano-homeostasis, by control loop organisationally akin thermoregulation. biophysical cost maintaining agent-medium density gradient defines task, which regulation mechanical force. Organism-level mechano-homeostasis must approximately maintain certain force field at surface organism (i.e. precisely cancels gravitational acceleration), or will fall, dissipate die. argument specifies this fluid, dynamical ‘balance’ for arbitrary morphologies configurations, describes how apprehend it developmentally their own embodiment. I motivate define examine against evidence, discuss implications, limitations scope understanding embodied spatiotemporal animacy in robots.

Language: Английский

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