Chlorogenic Acid Alleviates Inflammation and Fibrosis in a Murine Model of Bleomycin-Induced Systemic Sclerosis: A Histological Analysis DOI Creative Commons
Juan Manuel Velázquez-Enríquez,

Roxana Clarivel Mendoza-Crisostomo,

Edilburga Reyes-Jiménez

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 788 - 800

Published: Nov. 5, 2024

Background/Objectives: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by cutaneous and visceral fibrosis, vascular alterations, persistent inflammatory response. Despite advances in understanding the pathogenic mechanisms underlying SSc, current therapeutic options remain limited. Chlorogenic acid (CGA) polyphenol widely distributed plants has shown antioxidant, anti-inflammatory, antifibrotic properties. However, its potential SSc not been investigated yet. Methods: A model of was established administering bleomycin (BLM) at 100 U/kg to CD1 mice via an osmotic minipump. After fourteen days BLM administration, CGA (60 mg/kg) intragastric administered on consecutive until day 20. On 21, all were sacrificed. The effect histologically evaluated hematoxylin eosin Masson’s trichrome staining. Results: treatment significantly attenuated dermal fibrosis BLM-induced reducing histopathological damage, including increased thickness, inflammation, collagen deposition, SSc-associated pulmonary fibrosis. Conclusions: evidence shows that attenuates strongly suggests may be promising compound for SSc.

Language: Английский

Pathology of idiopathic pulmonary fibrosis with particular focus on vascular endothelium and epithelial injury and their therapeutic potential DOI Creative Commons

Wenying Lu,

Alan Teoh,

Maddison Waters

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: unknown, P. 108757 - 108757

Published: Nov. 1, 2024

Language: Английский

Citations

3
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis DOI Creative Commons
Kangchen Li, Xuefang Liu,

Ruilong Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 289, P. 117451 - 117451

Published: Dec. 2, 2024

Language: Английский

Citations

1
Chlorogenic Acid Alleviates Inflammation and Fibrosis in a Murine Model of Bleomycin-Induced Systemic Sclerosis: A Histological Analysis DOI Creative Commons
Juan Manuel Velázquez-Enríquez,

Roxana Clarivel Mendoza-Crisostomo,

Edilburga Reyes-Jiménez

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 788 - 800

Published: Nov. 5, 2024

Background/Objectives: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by cutaneous and visceral fibrosis, vascular alterations, persistent inflammatory response. Despite advances in understanding the pathogenic mechanisms underlying SSc, current therapeutic options remain limited. Chlorogenic acid (CGA) polyphenol widely distributed plants has shown antioxidant, anti-inflammatory, antifibrotic properties. However, its potential SSc not been investigated yet. Methods: A model of was established administering bleomycin (BLM) at 100 U/kg to CD1 mice via an osmotic minipump. After fourteen days BLM administration, CGA (60 mg/kg) intragastric administered on consecutive until day 20. On 21, all were sacrificed. The effect histologically evaluated hematoxylin eosin Masson’s trichrome staining. Results: treatment significantly attenuated dermal fibrosis BLM-induced reducing histopathological damage, including increased thickness, inflammation, collagen deposition, SSc-associated pulmonary fibrosis. Conclusions: evidence shows that attenuates strongly suggests may be promising compound for SSc.

Language: Английский

Citations

0