Phospholipids and Sphingolipids in Osteoarthritis
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 250 - 250
Published: Feb. 8, 2025
Many
studies
now
emphasize
the
intricate
relationship
between
lipid
metabolism
and
osteoarthritis
(OA),
a
leading
cause
of
disability.
This
narrative
review
examines
alterations
in
levels
phospholipids
(PLs)
sphingolipids
(SLs)
synovial
fluid
(SF),
plasma,
serum,
articular
tissues;
discusses
their
role
joint
lubrication,
inflammation,
cartilage
degradation;
describes
potential
as
diagnostic
markers
therapeutic
targets.
Key
findings
include
stage-dependent
elevated
specific
PLs
SLs
SF,
blood,
tissue
OA
patients,
implicating
them
possible
biomarkers
disease
severity
progression.
Studies
suggest
that
beyond
involvement
these
lipids
individual
species,
such
lysophosphatidylcholine
(LPC)
16:0,
lysophosphatidic
acid
(LPA),
ceramide-1-phosphate
(C1P),
sphingosine-1-phosphate
(S1P),
contribute
to
pain,
degradation
joints
through
various
signaling
pathways.
Cross-species
comparisons
dogs
mice
experience
similar
lipidomic
changes
during
humans,
rendering
valuable
models
for
studying
lipid-related
mechanisms.
SF
appear
originate
primarily
from
blood
capillaries
diffusion.
In
addition,
are
produced
locally
by
fibroblast-like
synoviocytes
(FLSs)
influenced
cytokines
growth
factors
regulate
biosynthesis
lubrication.
Emerging
research
has
identified
genes
UGCG
ESYT1
regulators
OA.
Further,
we
examine
suitability
targeting
PL
SL
pathways
treat
OA,
emphasizing
need
further
translate
into
clinical
applications.
Language: Английский
Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 160620 - 160620
Published: Feb. 1, 2025
Language: Английский
Novel insights into the role of ferroptosis in temporomandibular joint osteoarthritis and knee osteoarthritis
International Journal of Medical Sciences,
Journal Year:
2025,
Volume and Issue:
22(9), P. 2119 - 2131
Published: April 9, 2025
Osteoarthritis
(OA)
is
a
prevalent
degenerative
joint
disease
characterized
by
pain,
limited
movement,
and
stiffness,
significantly
impacting
the
quality
of
life
imposing
substantial
economic
burdens.
This
review
paper
delves
into
novel
insights
ferroptosis,
an
iron-dependent
form
cell
death
associated
with
lipid
peroxidation,
in
context
temporomandibular
osteoarthritis
(TMJ
OA)
knee
(KOA).
We
explore
pathogenic
characteristics
OA,
including
synovitis,
chondrocyte
death,
extracellular
matrix
(ECM)
degradation,
discuss
limitations
current
therapeutic
interventions.
Emerging
evidence
suggests
significant
relationship
between
ferroptosis
iron
accumulation
peroxidation
observed
osteoarthritic
cartilage.
highlights
role
malfunction
apoptosis,
inflammation,
breakdown,
which
are
central
to
OA
pathogenesis.
also
potential
targets,
such
as
Transient
Receptor
Potential
Vanilloid
1
(TRPV1),
Glutathione
Peroxidase
4
(GPX4),
Nuclear
Factor
Erythroid
2-Related
2
(NRF2),
modulate
progression.
The
consolidates
studies
on
offering
comprehensive
understanding
its
development
innovative
therapies
targeting
this
mechanism
improve
treatment
outcomes
for
patients.
Language: Английский
The Potential Regulatory Role of Ferroptosis in Orthodontically Induced Inflammatory Root Resorption
Leilei Wang,
No information about this author
Chuan Wang,
No information about this author
Hong He
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13617 - 13617
Published: Dec. 19, 2024
People,
in
increasing
numbers,
are
seeking
orthodontic
treatment
to
correct
malocclusion,
while
some
of
them
suffering
from
orthodontically
induced
inflammatory
root
resorption
(OIIRR).
Recent
evidence
suggests
that
the
immune-inflammatory
response
occurring
during
bone
remodeling
may
be
responsible
for
OIIRR.
Ferroptosis,
a
new
type
programmed
cell
death
(PCD),
has
been
found
have
close
interrelation
with
inflammation
disease
progression.
While
ferroptosis
extensively
studied
bone-related
diseases,
its
role
OIIRR
is
poorly
understood.
Considering
tooth
shares
lot
similar
characteristics
bone,
it
reasonable
hypothesize
contributes
development
Nevertheless,
direct
supporting
this
theory
currently
lacking.
In
review,
we
introduced
and
elucidated
mechanisms
underlying
movement
(OTM)
OIIRR,
special
focus
on
pivotal
plays
these
processes.
Additionally,
covered
recent
research
exploring
connections
between
ferroptosis.
Lastly,
emphasized
important
regulatory
function
homeostasis.
Further
investigations
required
clarify
modulation
develop
novel
potential
therapeutic
strategies
management
Language: Английский