Nuclear ESCRT is involved in intranuclear protein quality control by micronucleophagy DOI
Most Naoshia Tasnin,

Yuka Takahashi,

Tsuneyuki Takuma

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 744, P. 151219 - 151219

Published: Dec. 19, 2024

Language: Английский

Heat shock protein A1 inhibits the replication of foot-and-mouth disease virus by degrading viral RNA polymerase 3D through chaperone-mediated autophagy DOI Creative Commons
Mei Ren, Huan Zhou,

Jin’en Wu

et al.

Journal of Virology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

ABSTRACT Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae family, is single-stranded, positive-sense RNA virus. Heat shock protein A1 (HSPA1) has been shown to influence entry, translation, assembly, and release enterovirus A71 (EV-A71), another family member. In this study, we demonstrate that HSPA1 plays different role in replication FMDV. By investigating various stages replication, found specifically inhibits stage which viral by degrading RNA-dependent polymerase (RdRp), 3D protein. presence specific inhibitors, find out degradation occurs through autophagy pathway. Activation blockage chaperone-mediated (CMA) degrades CMA Mutation analysis reveals 421 QEKLI 425 key motif responsible for HSPA1-mediated degradation. summary, study shows can degrade pathway, thereby inhibiting FMDV interfering with infection. This first time, demonstrates employs its chaperone function mediate RdRp, revealing crucial infection process suggesting could be potential target prevention treatment IMPORTANCE Viral understanding pathogenic mechanisms foot-and-mouth (FMDV). During process, non-structural serves as an (RdRp) synthesize progeny using genomic template. However, regulatory effect host cells on proteins not yet studied. heat RdRp.

Language: Английский

Citations

0
Organelle homeostasis requires ESCRTs DOI Creative Commons
Tsan-Wen Lu, Adam Frost, Frank R. Moss

et al.

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 93, P. 102481 - 102481

Published: Feb. 14, 2025

Language: Английский

Citations

0
ESCRT elicits vacuolar fission in the absence of Vps4 in budding yeast DOI
Most Naoshia Tasnin,

Tsuneyuki Takuma,

Yuka Takahashi

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 746, P. 151244 - 151244

Published: Dec. 31, 2024

Language: Английский

Citations

0
Nuclear ESCRT is involved in intranuclear protein quality control by micronucleophagy DOI
Most Naoshia Tasnin,

Yuka Takahashi,

Tsuneyuki Takuma

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 744, P. 151219 - 151219

Published: Dec. 19, 2024

Language: Английский

Citations

0