Role of Mitochondrial Dysfunction in UV‐Induced Photoaging and Skin Cancers DOI
Xinghua Yuan,

Huixin Li,

Ji Su Lee

et al.

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(5)

Published: May 1, 2025

ABSTRACT Ultraviolet radiation (UVR) is the most detrimental external factor that induces acute photodamage, photoaging and skin cancers, with complex underlying molecular mechanisms initiated mainly by increased DNA damage reactive oxygen species (ROS) generation. Mitochondria are main organelles in cells produce ROS energy regulate various physiological pathological signalling pathways. Continuous UVR on human can induce mitochondrial mutations excessive production, creating feedback between each other subsequently causing a reduction membrane potential (MMP) respiratory capacity. Deficiencies function apoptosis, mitophagy senescence, resulting UVR‐induced photodamage photoaging. Mitochondrial biogenesis metabolic pathways play critical roles progression of particularly melanoma, which malignant infrequent type cancer. In this review, we describe recent advances determining intimate relationship damage, suggesting candidates novel chemical/natural components to protect from cancers via targeting mechanisms.

Language: Английский

Role of Mitochondrial Dysfunction in UV‐Induced Photoaging and Skin Cancers DOI
Xinghua Yuan,

Huixin Li,

Ji Su Lee

et al.

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(5)

Published: May 1, 2025

ABSTRACT Ultraviolet radiation (UVR) is the most detrimental external factor that induces acute photodamage, photoaging and skin cancers, with complex underlying molecular mechanisms initiated mainly by increased DNA damage reactive oxygen species (ROS) generation. Mitochondria are main organelles in cells produce ROS energy regulate various physiological pathological signalling pathways. Continuous UVR on human can induce mitochondrial mutations excessive production, creating feedback between each other subsequently causing a reduction membrane potential (MMP) respiratory capacity. Deficiencies function apoptosis, mitophagy senescence, resulting UVR‐induced photodamage photoaging. Mitochondrial biogenesis metabolic pathways play critical roles progression of particularly melanoma, which malignant infrequent type cancer. In this review, we describe recent advances determining intimate relationship damage, suggesting candidates novel chemical/natural components to protect from cancers via targeting mechanisms.

Language: Английский

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