Porous oxidized dextran sponges for surgical hemostasis and infection control DOI
Xu Hong, Siyuan Li, Peitao Zhuang

et al.

Journal of Biomaterials Applications, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Surgical procedures frequently result in varying degrees of bleeding and infection, which can impede patient recovery, particularly situations limited blood supply. Minimizing surgical loss preventing infections remain crucial clinical challenges. To address these tissues, we developed a porous hemostatic sponge by aldehyde-functionalizing dextran. The high porosity absorption capacity ODex sponges enables them to effectively concentrate red cells, platelets, coagulation factors, forming clot together with the matrix. aldehyde groups bind amines tissue, helping seal site. This innovation significantly reduced clotting times both vitro vivo experiments. Furthermore, demonstrated excellent biocompatibility potent antimicrobial activity. These findings highlight oxidized dextran as highly promising biomaterial strong capabilities, offering potential for broad applications.

Language: Английский

Porous oxidized dextran sponges for surgical hemostasis and infection control DOI
Xu Hong, Siyuan Li, Peitao Zhuang

et al.

Journal of Biomaterials Applications, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Surgical procedures frequently result in varying degrees of bleeding and infection, which can impede patient recovery, particularly situations limited blood supply. Minimizing surgical loss preventing infections remain crucial clinical challenges. To address these tissues, we developed a porous hemostatic sponge by aldehyde-functionalizing dextran. The high porosity absorption capacity ODex sponges enables them to effectively concentrate red cells, platelets, coagulation factors, forming clot together with the matrix. aldehyde groups bind amines tissue, helping seal site. This innovation significantly reduced clotting times both vitro vivo experiments. Furthermore, demonstrated excellent biocompatibility potent antimicrobial activity. These findings highlight oxidized dextran as highly promising biomaterial strong capabilities, offering potential for broad applications.

Language: Английский

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