The Interplay Between Immune and Metabolic Pathways in Kidney Disease DOI Open Access
Baihai Jiao, Lili Qu

Published: May 4, 2023

Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the global population. encompasses diverse group disorders that vary in their underlying pathophysiology, clinical presentation, and outcomes. These include acute kidney injury (AKI), chronic (CKD), glomerulonephritis, nephrotic syndrome, polycystic disease, diabetic many others. Despite distinct etiologies, these share common feature immune system dysregulation metabolic disturbances. The pathways are intimately connected interact to modulate pathogenesis diseases. responses diseases includes complex interplay between various cell types, including resident infiltrating cells, cytokines, chemokines, complement factors. factors can trigger perpetuate inflammation, causing renal tissue progressive fibrosis. In addition, play critical roles diseases, glucose lipid metabolism, oxidative stress, mitochondrial dysfunction, altered nutrient sensing. Dysregulation contributes progression by inducing tubular injury, apoptosis, Recent studies have provided insights into intricate revealing novel therapeutic targets for prevention treatment Potential strategies modulating through targeting key or inhibiting pro-inflammatory signaling pathways, improving function, nutrient-sensing such as mTOR, AMPK, SIRT1. This review highlights importance potential implications pathways.

Language: Английский

Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis DOI Creative Commons
Rikke Nørregaard, Henricus A. M. Mutsaers, Jørgen Frøkiær

et al.

Physiological Reviews, Journal Year: 2023, Volume and Issue: 103(4), P. 2847 - 2892

Published: July 13, 2023

The kidneys play a key role in maintaining total body homeostasis. complexity of this task is reflected the unique architecture organ. Ureteral obstruction greatly affects renal physiology by altering hemodynamics, changing glomerular filtration and metabolism, inducing architectural malformations kidney parenchyma, most importantly fibrosis. Persisting pathological changes lead to chronic disease, which currently ∼10% global population one major causes death worldwide. Studies on consequences ureteral date back 1800s. Even today, experimental unilateral (UUO) remains standard model for tubulointerstitial However, has certain limitations when it comes studying tubular injury repair, as well limited potential human translation. Nevertheless, provided scientific community with wealth knowledge (patho)physiology. With introduction advanced omics techniques, classical UUO remained relevant day been instrumental understanding fibrosis at molecular, genomic, cellular levels. This review details concepts recent advances obstructive nephropathy, highlighting pathophysiological hallmarks responsible functional induced obstruction, special emphasis

Language: Английский

Citations

52
Renal macrophages and NLRP3 inflammasomes in kidney diseases and therapeutics DOI Creative Commons
Mohammad Islamuddin, Xuebin Qin

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 13, 2024

Abstract Macrophages are exceptionally diversified cell types and perform unique features functions when exposed to different stimuli within the specific microenvironment of various kidney diseases. In instances tissue necrosis or infection, patterns associated with damage pathogens prompt development pro-inflammatory macrophages (M1). These M1 contribute exacerbating damage, inflammation, eventual fibrosis. Conversely, anti-inflammatory (M2) arise in same circumstances, contributing repair regeneration processes. Impaired causes fibrosis, hence play a protective pathogenic role. response harmful body, inflammasomes, complex assemblies multiple proteins, assume pivotal function innate immunity. The initiation inflammasomes triggers activation caspase 1, which turn facilitates maturation cytokines, death. kidneys possess complete elements NLRP3 inflammasome, including NLRP3, ASC, pro-caspase-1. When activated, it caspase-1, resulting release mature proinflammatory cytokines (IL)-1β IL-18 cleavage Gasdermin D (GSDMD). This process therefore then induces pyroptosis, leading renal death, dysfunction. NLRP3–ASC–caspase-1–IL-1β–IL-18 pathway has been identified as factor pathophysiology numerous this review, we explore current progress understanding macrophage behavior concerning injury, fibrosis kidneys. Emphasizing role activated both advancement recovery phases diseases, article delves into potential strategies modify functionality also discusses emerging approaches selectively target their signaling components kidney, aiming facilitate healing

Language: Английский

Citations

19
The Interplay between Immune and Metabolic Pathways in Kidney Disease DOI Creative Commons
Lili Qu, Baihai Jiao

Cells, Journal Year: 2023, Volume and Issue: 12(12), P. 1584 - 1584

Published: June 8, 2023

Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the global population. encompasses diverse group disorders that vary in their underlying pathophysiology, clinical presentation, and outcomes. These include acute kidney injury (AKI), chronic (CKD), glomerulonephritis, nephrotic syndrome, polycystic disease, diabetic many others. Despite distinct etiologies, these share common feature immune system dysregulation metabolic disturbances. The pathways are intimately connected interact to modulate pathogenesis diseases. responses diseases includes complex interplay between various cell types, including resident infiltrating cells, cytokines, chemokines, complement factors. factors can trigger perpetuate inflammation, causing renal tissue progressive fibrosis. In addition, play critical roles diseases, glucose lipid metabolism, oxidative stress, mitochondrial dysfunction, altered nutrient sensing. Dysregulation contributes progression by inducing tubular injury, apoptosis, Recent studies have provided insights into intricate revealing novel therapeutic targets for prevention treatment Potential strategies modulating through targeting key or inhibiting pro-inflammatory signaling pathways, improving function, nutrient-sensing such as mTOR, AMPK, SIRT1. This review highlights importance potential implications pathways.

Language: Английский

Citations

30
Role of mitochondria in pathogenesis and therapy of renal fibrosis DOI
Xiaodong Zhao, Yunkuo Li, Jinyu Yu

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 155, P. 155913 - 155913

Published: April 11, 2024

Language: Английский

Citations

15
The Kidney in Obesity: Current Evidence, Perspectives and Controversies DOI
Dimitris Kounatidis, Natalia G. Vallianou, Theodora Stratigou

et al.

Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(4), P. 680 - 702

Published: Aug. 14, 2024

Language: Английский

Citations

9
Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors DOI
Min Qiao, Junjun Ni,

Hong Qing

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

1
Oleuropein attenuates the nephrotoxic effect of sunitinib in rats: Unraveling the potential role of SIRT6/Notch-1/NLRP-3/IL-1β axis DOI
Rania A. Elrashidy, Hoda E. Mohamed, Sara M. Abdel Aal

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 755, P. 109986 - 109986

Published: April 4, 2024

Language: Английский

Citations

4
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis DOI

Varnita Karmakar,

Mayukh Chain,

Ankit Majie

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

0
Repurposing Secukinumab and Dapagliflozin as Candidate Therapies to Mitigate the Renal Toxicity of Sunitinib in Rats Through Suppressing IL‐17‐Mediated Pyroptosis and Promoting Autophagy DOI Open Access
Rania A. Elrashidy,

Hoda E. Mohamad,

Sara M. Abdel Aal

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: March 1, 2025

Sunitinib (SUN) is a chemotherapeutic agent showing renal toxicity that limits its clinical applications. The present research aimed to clarify the potential ameliorative effects of secukinumab (SEC) and dapagliflozin (DAPA) against SUN-induced underpinning molecular mechanisms. For this purpose, adult Wistar albino rats were received SUN (25 mg/kg 3 times/week, po) co-treated with SEC (3 mg/kg/every 2 weeks, subcutaneously) or DAPA (10 mg/kg/day, for 4 weeks compared age-matched control group (CON). Markers kidney functions assessed in serum samples. Kidneys harvested biochemical histological examination. Compared CON group, SUN-treated displayed signs dysfunction along changes ameliorated by DAPA. Both drugs significantly lowered levels IL-17, but exerted more inhibitory effect than Additionally, SUN-subjected showed significant increases expression NLRP3 inflammasome other inflammatory mediators including IL-1β, END-1, MCP-1. This was associated marked decline beclin-1. Co-treatment suppressed NLRP3-induced inflammation while enhanced beclin-1-mediated autophagy. modulatory on beclin-1 superior SEC. Moreover, both similarly attenuated cleaved caspase-3 interstitial fibrosis tissue rats. Collectively, these findings may repurpose as candidate therapies alleviate rescue functionality cancer cases.

Language: Английский

Citations

0
A Systematic Review of risk factors for major adverse cardiovascular events in patients with coronary heart disease who underwent percutaneous coronary intervention DOI Creative Commons
You Zhai, Hongcai Shang, Yan Li

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

This study aims to systematically review the risk factors for major adverse cardiovascular events (MACE) in patients with coronary heart disease who have undergone percutaneous intervention (PCI). Systematic and meta-analysis. The Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database Chinese Technical Periodicals (VIP) were screened until December 2024. Case-control studies or cohort on MACE underwent PCI. Data extraction synthesis: literature review, data extraction, quality evaluation conducted by two independent researchers, meta-analysis was performed using RevMan 5.4 software. main outcome that occurred during follow-up period. A total 40 articles included. erevealed dyslipidemia (OR = 1.50; 95% CI [1.19, 1.89], p 0.0007), diabetes mellitus 1.70; [1.43, 2.02], < 0.00001), hypertension 1.62; [1.35, 1.96], 0.0001), history smoking 2.08; [1.51, 2.85], poorer ventricular function 2.39; [2.17-2.64], impaired left ejection fraction (LVEF) 1.86; [1.71-2.03], door balloon (D-to-B) time 0.61; [0.42-0.88]; 0.009), thrombolysis myocardial infarction (TIMI) 1.41; [1.17, 1.70], 0.0004), renal dysfunction 1.82; [1.37, 2.43], multi-vessel artery 0.41; [0.37, 0.46], 0.0001) significantly associated after PCI are dyslipidemia, hypertension, mellitus, history, Killip class > II, LVEF ≤40%, D-to-B >90 min, TIMI flow grade ≤ insufficiency, multivessel disease.

Language: Английский

Citations

0