Artificial Intelligence-Driven Analysis of Antimicrobial-Resistant and Biofilm-Forming Pathogens on Biotic and Abiotic Surfaces

Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 788 - 788

Published: Aug. 22, 2024

The growing threat of antimicrobial-resistant (AMR) pathogens to human health worldwide emphasizes the need for more effective infection control strategies. Bacterial and fungal biofilms pose a major challenge in treating AMR pathogen infections. Biofilms are formed by pathogenic microbes encased extracellular polymeric substances confer protection from antimicrobials host immune system. also promote growth antibiotic-resistant mutants latent persister cells thus complicate therapeutic approaches. ubiquitous cause serious risks due their ability colonize various surfaces, including tissues, medical devices, food-processing equipment. Detection characterization crucial prompt intervention control. To this end, traditional approaches often effective, yet they fail identify microbial species inside biofilms. Recent advances artificial intelligence (AI) have provided new avenues improve biofilm identification. Machine-learning algorithms image-processing techniques shown promise accurate efficient detection biofilm-forming microorganisms on biotic abiotic surfaces. These advancements potential transform research clinical practice allowing faster diagnosis tailored therapy. This comprehensive review focuses application AI identification industries, healthcare, food safety, agriculture. discusses existing approaches, challenges, applications research, with particular focus role improving diagnostic capacities guiding preventative actions. synthesis current knowledge future directions, as described review, will guide development efforts combating biofilm-associated

Language: Английский

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Viable but non-cultivable state in oral microbiota: a critical review of an underexplored microbial survival strategy

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 18, 2025

The viable but non-cultivable (VBNC) state and persister cells, two dormancy phenomena in bacteria, differ various aspects. entry of bacteria into the VBNC as a survival strategy under stressful conditions has gained increasing attention recent years, largely due to higher tolerance cells antibiotics antimicrobials resulting from their low metabolic activity. oral cavity favors biofilm growth dental hard tissues, tooth decay periodontitis. Despite advances detection food industry environment, capability remains poorly documented. Furthermore, recently been observed pathogens, including Porphyromonas gingivalis, which shows potential relevance chronic systemic infections, Enterococcus faecalis, an important taxon endodontic Helicobacter pylori, exhibits transient presence cavity. Further research could create opportunities develop novel therapeutic strategies control pathogens. inability conventional culture-based methods identify reactivation dormant restore susceptibility therapies highlights notable gap anti-VBNC strategies. lack targeted approaches tested for efficacy against underscores need methods. This review discusses state, its importance public health, diagnostic techniques, with special focus on bacteria.

Language: Английский

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The Integration of Gold Nanoparticles into Dental Biomaterials as a Novel Approach for Clinical Advancement: A Narrative Review

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 291 - 291

Published: Sept. 30, 2024

Gold nanoparticles (AuNPs) have gained significant attention in the biomedical field owing to their versatile properties. AuNPs can be customized by modifying size, shape and surface characteristics. In recent years, extensive research has explored integration of into various dental materials, including titanium, polymethylmethacrylate (PMMA) resin composites. This review aims summarize advancements application modified materials assess effects on related cellular processes field. Relevant articles published English association with were identified through a systematic search PubMed/MEDLINE, Embase, Scopus ScienceDirect databases from January 2014 April 2024. Future prospects for utilization dentistry are surveyed.

Language: Английский

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Nanobots: The future of oral infection treatment

Published: Aug. 1, 2024

Oral diseases such as gingivitis and periodontitis represent signi cant global health challenges, a ecting substantial portion of the population.These conditions, driven by bacterial bio lms, can cause severe damage to tooth-supporting tissues, leading tooth loss impacting overall well-being.Traditional oral antibiotics face limitations, including broad-spectrum side e ects insu cient concentration at infection sites, often resulting in antimicrobial resistance.This mini-review explores potential nanobots for targeted drug delivery treating infections.Nanobots, ranging from 1 100 nanometers, navigate cavity, directly targeting lms releasing agents controlled manner.This approach enhances reduces systemic ects, minimizes resistance development.Various types nanobots, dentifrobots pharmacytes, are discussed their roles healthcare.Recent advancements demonstrate cacy vitro vivo, highlighting ability eradicate deliver drugs precisely.However, challenges biocompatibility, stability, regulatory hurdles must be addressed clinical application.Future directions include integrating multifunctional capabilities simultaneous treatment tissue repair, real-time monitoring through advanced imaging biosensing, personalized therapies tailored individual microbiomes.By overcoming these have revolutionize healthcare, o ering innovative solutions ectively manage treat infections, ultimately improving patient outcomes health.

Language: Английский

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Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Sept. 5, 2024

fluoride is a beneficial ion that has been used in various fields, from industrial products to therapeutics. However, due its narrow therapeutic index, sometimes acts as toxic agent at relatively higher concentrations the human body. Based on interest genetic stability, cytotoxic effects have investigated mainly nucleated, adherent cells, such fibroblasts. sensitivity of blood especially anucleate platelets, poorly understood. To fill this gap literature, we low levels platelet energy metabolism, function, and viability.

Language: Английский

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Classical and Modern Models for Biofilm Studies: A Comprehensive Review

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1228 - 1228

Published: Dec. 18, 2024

Biofilms are structured microbial communities that adhere to various abiotic and biotic surfaces, where organisms encased in an exo-polysaccharide matrix. Organisms within biofilms use mechanisms help them resist external challenges, such as antibiotics, rendering more resistant drugs. Therefore, researchers have attempted develop suitable laboratory models study the physical features of biofilms, their resistance against antimicrobial agents, gene protein expression profiles. However, current suffer from limitations. In this comprehensive review, we summarized designs been used for biofilm models, presenting strengths Additionally, provided insight into improving these closely simulate real-life scenarios, using newly developed techniques additive manufacturing, synthetic biology, bioengineering.

Language: Английский

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Revolutionizing Climbing Perch Disease Management: AI-Driven Solutions for Sustainable Aquaculture

Smart Agricultural Technology, Journal Year: 2024, Volume and Issue: unknown, P. 100746 - 100746

Published: Dec. 1, 2024

Language: Английский

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