Progress and perspective on hydrogen sulfide donors and their biomedical applications DOI
Zi‐Long Song, Lanning Zhao, Tao Ma

et al.

Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 42(5), P. 1930 - 1977

Published: June 3, 2022

Abstract Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H 2 S) has been identified as third gasotransmitter in humans. Increasing evidence have shown that H S is preventive or therapeutic effects on diverse pathological complications. As a consequence, it great significance to develop suitable approaches S‐based therapeutics for biomedical applications. S‐releasing agents donors) play important roles exploring understanding physiological functions S. More importantly, accumulating studies validated theranostic potential donors extensive repertoires vitro vivo disease models. Thus, imperative summarize update literatures this field. In review, first, background its chemical biological aspects concisely introduced. Second, regarding compounds are categorized described, accordingly, their S‐donating mechanisms, applications, values also comprehensively delineated discussed. Necessary comparisons between related presented, drawbacks many typical analyzed revealed. Finally, several critical challenges encountered development multifunctional discussed, direction future well applications proposed. We expect review will reach audiences across multiple disciplines promote innovation biomedicine.

Language: Английский

A review of the green chemistry approaches to leather tanning in imparting sustainable leather manufacturing DOI
Mohammad Mahbubul Hassan,

Jane Gary Harris,

James J. C. Busfield

et al.

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(19), P. 7441 - 7469

Published: Jan. 1, 2023

Green chemistry approaches studied for leather tanning are critically reviewed. The performance and mechanical properties discussed. mechanisms of various agents future directions outlined.

Language: Английский

Citations

46
MoS2-GO hybrid sensor: A discerning approach for detecting harmful H2S gas at room temperature DOI
Gajanan M. Hingangavkar, Sujit A. Kadam, Yuan‐Ron Ma

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144789 - 144789

Published: July 16, 2023

Language: Английский

Citations

44
Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease DOI Open Access
Zhen Li,

David J. Polhemus,

David J. Lefer

et al.

Circulation Research, Journal Year: 2018, Volume and Issue: 123(5), P. 590 - 600

Published: Aug. 17, 2018

Hydrogen sulfide (H 2 S)—a potent gaseous signaling molecule—has emerged as a critical regulator of cardiovascular homeostasis. H S is produced enzymatically by 3 constitutively active endogenous enzymes in all mammalian species. Within the past decades, studies administering S-donating agents and genetic manipulation S-producing have revealed multiple beneficial effects S, including vasodilation, activation antiapoptotic antioxidant pathways, anti-inflammatory effects. More recently, heightened enthusiasm this field has shifted to development novel that exert favorable pharmacological profiles. This led discovery S-mediated pathways. review will discuss recently developed therapeutics, introduce pathways are influenced S-dependent sulfhydration, explore dual-protective effect cardiorenal syndrome.

Language: Английский

Citations

119
Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses DOI Creative Commons
Virender Kumar Pal, Parijat Bandyopadhyay, Amit Singh

et al.

IUBMB Life, Journal Year: 2018, Volume and Issue: 70(5), P. 393 - 410

Published: March 30, 2018

Abstract An increasing number of studies have established hydrogen sulfide (H 2 S) gas as a major cytoprotectant and redox modulator. Following its discovery, H S has been found to pleiotropic effects on physiology human health. acts gasotransmitter exerts influence gastrointestinal, neuronal, cardiovascular, respiratory, renal, hepatic systems. Recent discoveries clearly indicated the importance in regulating vasorelaxation, angiogenesis, apoptosis, ageing, metabolism. Contrary higher organisms, role pathophysiology infectious agents such bacteria viruses less studied. Bacterial viral infections are often accompanied by changes both host pathogen. Emerging indicate that bacterial‐derived constitutes defense system against antibiotics oxidative stress. The signaling pathway also seems interfere with redox‐based events affected infection viruses. This review aims summarize recent advances emerging bacterial infections. Such opened up new research avenues exploiting potential therapeutic intervention. © 2018 Authors IUBMB Life published Wiley Periodicals, Inc. behalf International Union Biochemistry Molecular Biology, 70(5):393–410,

Language: Английский

Citations

104
Activatable Small-Molecule Hydrogen Sulfide Donors DOI
Carolyn M. Levinn, Matthew M. Cerda, Michael D. Pluth

et al.

Antioxidants and Redox Signaling, Journal Year: 2019, Volume and Issue: 32(2), P. 96 - 109

Published: Sept. 26, 2019

Significance: Hydrogen sulfide (H2S) is an important biological signaling molecule involved in many physiological processes. These diverse roles have led researchers to develop contemporary methods deliver H2S under physiologically relevant conditions and response various stimuli. Recent Advances: Different small-molecule donors been developed that release conditions. Key examples include activated hydrolysis, endogenous species, such as thiols, reactive oxygen enzymes, external stimuli, photoactivation bio-orthogonal chemistry. In addition, alternative approach has utilized the catalyzed hydrolysis of carbonyl (COS) by carbonic anhydrase generate libraries activatable COS-based donors. Critical Issues: Small-molecule provide research pharmacological tools perturb levels. needs, both development use donors, access new respond specific stimuli well with well-defined control compounds allow for clear delineation impact delivery from other donor byproducts. Future Directions: The abundance reported provides biologists physiologists a chemical toolbox ask key questions H2S-related therapeutic interventions. Further investigation into different releasing efficiencies contexts understanding responses gradually (e.g., hours days) versus quickly seconds minutes) needed.

Language: Английский

Citations

96
Atmospheric H2S triggers immune damage by activating the TLR-7/MyD88/NF-κB pathway and NLRP3 inflammasome in broiler thymus DOI
Xueyuan Hu, Qianru Chi, Qingqing Liu

et al.

Chemosphere, Journal Year: 2019, Volume and Issue: 237, P. 124427 - 124427

Published: July 22, 2019

Language: Английский

Citations

93
Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases DOI Creative Commons
Yuyi Han,

Qianwen Shang,

Jin Yao

et al.

Cell Death and Disease, Journal Year: 2019, Volume and Issue: 10(4)

Published: March 29, 2019

Hydrogen sulfide (H

Language: Английский

Citations

89
Hydrogen sulfide inhalation-induced immune damage is involved in oxidative stress, inflammation, apoptosis and the Th1/Th2 imbalance in broiler bursa of Fabricius DOI
Xueyuan Hu, Qianru Chi, Dongxu Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2018, Volume and Issue: 164, P. 201 - 209

Published: Aug. 14, 2018

Language: Английский

Citations

88
Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells DOI

Fiona Augsburger,

Csaba Szabó

Pharmacological Research, Journal Year: 2018, Volume and Issue: 154, P. 104083 - 104083

Published: Nov. 27, 2018

Language: Английский

Citations

87
Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells DOI Creative Commons
Csaba Szabó

Cells, Journal Year: 2021, Volume and Issue: 10(2), P. 220 - 220

Published: Jan. 22, 2021

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed primary mode its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles H2S an endogenously produced mammalian gaseous transmitter. Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) 3-mercaptopyruvate sulfurtransferase (3-MST) are currently principal H2S-generating enzymes. In contrast to inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, serves stimulator electron transport in mitochondria, by acting donor—with sulfide:quinone oxidoreductase (SQR) being immediate acceptor. The significant various cancer cells, many which exhibit high expression partial localization producing addition stimulation ATP production, endogenous cells include maintenance organization (protection against fission) DNA repair (via assembly complexes). current article overviews state-of-the-art knowledge regarding functions cells.

Language: Английский

Citations

85