Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153364 - 153364
Published: June 20, 2024
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(5), P. 1919 - 1955
Published: Feb. 11, 2023
Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting single session insufficient to tackle this. CHF characterized by reduced cardiac output resulting from neurohumoral dysregulation remodeling, which might be related oxidative stress, inflammation, endoplasmic reticulum apoptosis, autophagy, mitochondrial function, angiogenesis. These molecular mechanisms interact each other through crosstalk. Historically, Chinese medicinal herbs have been widely applied in the of CHF, therapeutic effects their ingredients scientifically confirmed over past decades. Traditional medicine (TCM) multiple components can confront different pathogenesis targets. This review analyzes commonly used TCM patent drugs decoctions that are applicable stages based on clinical trials. Diverse bioactive found treat via mechanisms. comprehensively covers key works underlying TCM, herbal synergistic constituent compatibility treating providing additional ideas address this threat.
Language: Английский
Citations
56
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: July 28, 2023
Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic globally, and its associated complications including insulin resistance diabetes have become threatening conditions for human health. Previous studies on non-alcoholic (NAFLD) were focused liver's lipid metabolism. However, growing evidence suggests that mitochondrial metabolism involved in pathogenesis of NAFLD to varying degrees several ways, instance cellular division, oxidative stress, autophagy, quality control. Ultimately, function gradually declines as a result dysfunction. The unable transfer excess droplets outside liver. Therefore, how regulate hepatic treat has focus current research. This review provides details about intrinsic link with mechanisms by which dysfunctions contribute progression. Given crucial role progression, application potential multiple improvement modalities (including physical exercise, diabetic medications, small molecule agonists targeting Sirt3, mitochondria-specific antioxidants) treatment was evaluated hoping provide new insights into treatment.
Language: Английский
Citations
53
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8982 - 8982
Published: May 19, 2023
Calcium is an essential intracellular messenger that plays a vital role in controlling broad range of cellular processes, including apoptosis. This review offers in-depth analysis calcium’s multifaceted apoptosis regulation, focusing on the associated signaling pathways and molecular mechanisms. We will explore impact through its effects different compartments, such as mitochondria endoplasmic reticulum (ER), discuss connection between calcium homeostasis ER stress. Additionally, we highlight interplay various proteins, calpains, calmodulin, Bcl-2 family members, regulating caspase activation pro-apoptotic factor release. By investigating complex relationship apoptosis, this aims to deepen our comprehension fundamental pinpointing possible treatment options for illnesses with imbalanced cell death crucial.
Language: Английский
Citations
44
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease without effective treatment. The progressive motoneuron death in ALS associated with alterations lipid metabolism. As its regulation occurs mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), modulation of mitochondria-ER contacts (MERCs) emerging as crucial factor MAM formation and metabolism control. Using the MERLIN biosensor high-throughput screening within EU-OPENSCREEN ERIC, we discovered small molecules that increase MERCs HCT116 cells, enhancing their ability to uptake cholesterol. We demonstrated cholesterol trafficking decreased an patient-derived cell model, this restored after treatment MERC modulator 24. Electron microscopy revealed compound 24 increases MERCs, promotes droplet formation, restores mitochondrial cristae. Overall, brain-permeable modulator, 24, may serve valuable pharmacological tool for studying function holds potential vivo studies other dysfunction diseases.
Language: Английский
Citations
3
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 869, P. 161741 - 161741
Published: Jan. 21, 2023
Language: Английский
Citations
34
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 221 - 234
Published: Sept. 28, 2023
Language: Английский
Citations
34
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: May 16, 2023
Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity cellular homeostasis. Several pathways have been found participate in different steps mitophagy. plays significant role the homeostasis physiological function vascular endothelial cells, smooth muscle macrophages, involved development atherosclerosis (AS). At present, many medications natural chemicals shown alter mitophagy slow progression AS. This review serves as an introduction field for researchers interested targeting this pathway part potential AS management strategy.
Language: Английский
Citations
32
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101951 - 101951
Published: May 8, 2023
Organelles form tight connections through membrane contact sites, thereby cooperating to regulate homeostasis and cell function. Among them, the between endoplasmic reticulum (ER), main intracellular calcium storage organelles, mitochondria has been recognized for decades, its roles in ion lipid transport, ROS signaling, dynamic changes cellular metabolism are basically determined. At present, many tumor chemotherapeutic drugs rely on ER-mitochondrial signal function, but mechanism of targeting resident molecules at mitochondria-associated membranes (MAM) sensitize traditional chemotherapy new therapeutic targets identified based pathways MAM have not thoroughly discussed. In this review, we highlight key various signaling ER-mitochondria site tumorigenesis focus novel anticancer therapy strategies potential site.
Language: Английский
Citations
24
Life Sciences, Journal Year: 2024, Volume and Issue: 342, P. 122540 - 122540
Published: Feb. 29, 2024
Transcatheter arterial chemoembolisation (TACE) is the standard of care for intermediate-stage hepatocellular carcinoma and selected patients with advanced carcinoma. However, TACE does not achieve a satisfactory objective response rate, concept refractoriness has been proposed to identify who do fully benefit from TACE. Moreover, repeated necessary obtain an optimal sustained anti-tumour response, which may damage patient's liver function. Therefore, studies have recently performed improve effectiveness In this review, we summarise detailed molecular mechanisms associated responsiveness relapse after treatment provide more effective targets adjuvant therapy while helping regimens.
Language: Английский
Citations
10
Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Language: Английский
Citations
1