Prevention of motor relapses and associated trigeminal pain in experimental autoimmune encephalomyelitis by reducing neuroinflammation with a purple corn extract enriched in anthocyanins

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117906 - 117906

Published: Feb. 16, 2025

Language: Английский

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Moderate dietary flavonoid intake associated with lower prevalence of Parkinson’s disease: data from the NHANES 2007–2010 and 2017–2018

Neurological Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: March 25, 2025

To investigate the relationship between dietary flavonoids and prevalence of PD. We used data from 2007-2010 2017-2018 National Health Nutrition Examination Survey (NHANES). Dietary flavonoid intake was assessed through a two-day, 24-hour recall method, PD diagnosis ascertained by presence 'Anti-Parkinson agents' among reported prescription medications. Logistic regression, subgroup, restricted cubic spline (RCS) models were employed to analyze connection prevalence. Our study revealed correlation consumption total flavonoids, flavan-3-ols, flavonols, risk. Subgroup analysis indicated negative flavan-3-ols with risk only non-obese participants. Furthermore, our using RCS demonstrated nonlinear association found that optimal flavonols wase 403.65 mg/day,346 mg/day 26.74 mg/day, respectively. Above these thresholds, developing is elevated. highlights significant moderate reduced work may provide new therapeutic ideas for prevention treatment recommendations patients.

Language: Английский

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Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1129 - 1129

Published: May 7, 2025

Background/Objectives: Major depressive disorder (MDD) is a major global health concern that intimately linked to neuroinflammation, oxidative stress, mitochondrial dysfunction, and complicated metabolic abnormalities. Traditional antidepressants frequently fall short, highlighting the urgent need for new, safer, more acceptable therapeutic techniques. Phytochemicals, i.e., natural derived from plants, are emerging as powerful plant-based therapies capable of targeting many pathogenic pathways at same time. Summary: This narrative review synthesizes evidence preclinical clinical studies on efficacy phytochemicals such curcumin, polyphenols, flavonoids, alkaloids in lowering depressed symptoms. Consistent data show these substances have neuroprotective, anti-inflammatory, antioxidant properties, altering neuroimmune interactions, reducing damage, improving resilience. Particularly, polyphenols flavonoids great potential because their capacity penetrate blood–brain barrier, inhibit cytokine activity, encourage neuroplasticity mediated by brain-derived neurotrophic factor (BDNF). Despite promising results, heterogeneity study designs, phytochemical formulations, patient demographics highlights importance thorough, standardized studies. Conclusions: identifies compelling adjuvant or independent depression treatment, providing multimodal mechanisms enhanced tolerability. Additional research into improved dosage, pharmacokinetics, long-term safety, integrative therapy approaches essential. Using phytotherapeutics could considerably improve holistic customized care, encouraging new routes neuroscience psychiatry.

Language: Английский

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Integrated proteomic network analysis reveals PTPRC as a central hub protein orchestrating co-expression modules and metabolic dysregulation in renal carcinoma: PTPRC protein molecular action

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 144056 - 144056

Published: May 8, 2025

Language: Английский

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Utilization of Sustainable Ingredients (Cañihua Flour, Whey, and Potato Starch) in Gluten-Free Cookie Development: Analysis of Technological and Sensorial Attributes

Foods, Journal Year: 2024, Volume and Issue: 13(10), P. 1491 - 1491

Published: May 11, 2024

In recent years, the consumption of gluten-free products has increased due to increasing prevalence celiac disease and preference for diets. This study aimed make cookies using a mixture cañihua flour, whey, potato starch. The use Box–Behnken design allowed flexible ingredient proportions physicochemical properties, centesimal composition, color, texture, sensory attributes be evaluated through consumer tests (Sorting acceptability). results highlighted significant variations in data, texture across formulations. blend with 38.51% 10.91% sweet 25.69% starch, 8.34% margarine, 11.10% sugar, 0.19% sodium chloride, 0.51% baking powder, vanilla essence, 4.24% egg exhibited superior appeal. formulation boasted excellent aroma, flavor, appearance, indicating high quality. starch not only provides option but also delivers nutritious sensorily pleasing choice those dietary restrictions. Future research could explore commercial viability producing these on larger scale, as well investigating potential health benefits ingredients.

Language: Английский

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Perspective: Challenges and Future Directions in Clinical Research with Nuts and Berries

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(5), P. 1005 - 1028

Published: Aug. 2, 2023

Consumption of nuts and berries are considered part a healthy eating pattern. Nuts contain complex nutrient profile consisting essential vitamins minerals, fiber, polyunsaturated fatty acids, phenolics in quantities that improve physiological outcomes. The spectrum health outcomes may be impacted by the consumptions includes cardiovascular, gut microbiome, cognitive, among others. Recently, new insights regarding bioactive compounds found both have reinforced their role for use precision nutrition efforts. However, challenges exist can affect generalizability from clinical studies, including inconsistency study designs, homogeneity test populations, variability products control foods, assessing realistic portion sizes. Future research centered on multi-omics technologies will yield insights. These other topics such as funding streams perceived risk-of-bias were explored at an international conference focused nutrition. Successes, challenges, future directions with these foods presented here.

Language: Английский

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Effect of Dietary Flavonoids on Circadian Syndrome: A Population-Based Cross-Sectional Study

Metabolic Syndrome and Related Disorders, Journal Year: 2024, Volume and Issue: 22(5), P. 385 - 393

Published: March 7, 2024

Altering the dietary patterns can potentially decrease likelihood of metabolic syndrome and circadian (CircS), but it remains unclear which types flavonoid compounds are responsible for these effects, particularly among nationally representative populations. Thus, we conducted a cross-sectional study to investigate impact intake on CircS.

Language: Английский

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Effects of a Functional Cone Mushroom (Termitomyces fuliginosus) Protein Snack Bar on Cognitive Function in Middle Age: A Randomized Double-Blind Placebo-Controlled Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3616 - 3616

Published: Oct. 24, 2024

: Due to the rising prevalence of cognitive impairment in middle-aged and elderly population, combined with consumer demand for functional foods improve health well-being.

Language: Английский

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Phytochemicals from edible flowers prevent neurodegenerative diseases via the gut-brain axis

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105681 - 105681

Published: Dec. 1, 2024

Language: Английский

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Therapeutic Role of Desmodium Species on its Isolated Flavonoids

Current Molecular Medicine, Journal Year: 2022, Volume and Issue: 24(1), P. 74 - 84

Published: Dec. 14, 2022

Secondary metabolites are an important part to play a major role in society and it was isolated from plant flavonoids useful the treatment of various kinds diseases human race. They widely used as food nutrition supplements well antioxidants. Traditionally,

Language: Английский

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