Biochanin A prevents buccal pouch carcinogenesis by enhancing carcinogen detoxification and antioxidant status in hamsters

Journal of King Saud University - Science, Journal Year: 2023, Volume and Issue: 36(2), P. 103067 - 103067

Published: Dec. 16, 2023

This study objective was to ascertain the drug biochanin A (BCA) impacts on management of oral squamous cell carcinoma (OSCC) caused by chemical 7,12-dimethylbenz[a]anthracene (DMBA) in male Syrian golden hamsters. The cancer induced application a DMBA (0.5 %) thrice week for duration fourteen weeks buccal pouch. assessed various parameters, including volume, incidence, and burden tumors within hamsters' pouches. Additionally, it employed colorimetric methods measure levels carcinogen-detoxifying agents, lipid peroxidation, antioxidant activity. histopathological examination tissues, as well. hamsters exposed exhibited growth throughout pouches, accompanied notable changes levels, agents. However, administration BCA (20 mg/kg bw) every second day showed significant alteration reduced DMBA-exposed established substantial anti-lipid peroxidation effects ability enhance agent animals. outcomes this investigation emphasize chemopreventive capability against DMBA-induced

Language: Английский

Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective

Exploration of neuroscience, Journal Year: 2024, Volume and Issue: 3(2), P. 103 - 129

Published: April 7, 2024

Background: The main objective of the study was to carry out a systematic literature review investigate beneficial role antioxidants in obesity and diabetes association neuro-gliopathies gut microbiome on antioxidant production enteric nervous system (ENS) protection. Methods: A search done electronically 8 June 2022 databases Google Scholar, PubMed, reviewing all articles published English. There were no limitations for (region, or any time frame). included randomized controlled trials (RCTs) observational studies human subject, primarily focusing information such as change body weight, mass index (BMI), waist-to-height ratio (WHtR), waist-to-hip (WHR), fasting blood glucose level, glycated haemoglobin (HbA1c), other parameters that connected with obesity. also conducted microbiome. Results: beginning database picked total 2,428 articles, 1,310 876 242 records from sources. 2,040 (total duplicates 388) found after removing duplicated reading title abstracts further decreased 139 full-text articles. These went analysis, which resulted exclusion 123 generated final 16 systemic analysis. Discussion: This present shows interconnection between intake among obese neuro-gliopathies. findings indicate both diabetic patients have minimum content antioxidants, especially carotenoids, retinol, ascorbic acid, tocopherol, magnesium, zinc. While few research illustrated ingestion abovementioned lowered subjects contrast their normal-weight population, this not endorsed by every study.

Language: Английский

Gut microbiome, epigenetics, and neuro-inflammatory disease

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 297 - 332

Published: Nov. 29, 2024

Language: Английский