Intratumoral delivery of a Tim-3 antibody-encoding oncolytic adenovirus engages an effective antitumor immune response in liver cancer DOI Creative Commons
Qiang Li,

huii Zhang,

Leilei Zhang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Abstract The use of oncolytic viruses as a gene therapy vector is an area active biomedical research, particularly in the context cancer treatment. However, actual therapeutic success this approach to tumor elimination remains limited. As such, present study was developed with goal simultaneously enhancing antitumor efficacy and local immune response by combining Ad-GD55 adenovirus antibody specific for TIM-3 checkpoint molecule (α-TIM-3). resultant Ad-GD55-α-Tim-3 capable inducing α-TIM-3 expression within hepatoma cells upon infection, exhibited inhibitory superior that when used treat these together induction enhanced intracellular immunity. In vivo experiments revealed Ad-GD55-α-TIM-3 administration sufficient inhibit growth engage more robust simulated microenvironment. may represent viable treatment hepatocellular carcinoma.

Language: Английский

Intratumoral delivery of a Tim-3 antibody-encoding oncolytic adenovirus engages an effective antitumor immune response in liver cancer DOI Creative Commons
Qiang Li,

huii Zhang,

Leilei Zhang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Abstract The use of oncolytic viruses as a gene therapy vector is an area active biomedical research, particularly in the context cancer treatment. However, actual therapeutic success this approach to tumor elimination remains limited. As such, present study was developed with goal simultaneously enhancing antitumor efficacy and local immune response by combining Ad-GD55 adenovirus antibody specific for TIM-3 checkpoint molecule (α-TIM-3). resultant Ad-GD55-α-Tim-3 capable inducing α-TIM-3 expression within hepatoma cells upon infection, exhibited inhibitory superior that when used treat these together induction enhanced intracellular immunity. In vivo experiments revealed Ad-GD55-α-TIM-3 administration sufficient inhibit growth engage more robust simulated microenvironment. may represent viable treatment hepatocellular carcinoma.

Language: Английский

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