Phytochemicals targeting Alzheimer's disease via the AMP-activated protein kinase pathway, effects, and mechanisms of action

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116373 - 116373

Published: March 4, 2024

Alzheimer's disease (AD), characterized by cognitive dysfunction and other behavioral abnormalities, is a progressive neurodegenerative that occurs due to aging. Currently, effective drugs mitigate or treat AD remain unavailable. associated with several abnormalities in neuronal energy metabolism, such as decreased glucose uptake, mitochondrial dysfunction, defects cholesterol metabolism. Amp-activated protein kinase (AMPK) an important serine/threonine regulates the status of cells. AMPK widely present eukaryotic cells can sense regulate metabolism maintain supply demand balance, making it promising target for metabolism-based therapy. Therefore, this review aimed discuss molecular mechanism pathogenesis provide theoretical basis development new anti-AD drugs. To mechanisms phytochemicals treatment via pathway regulation, we searched PubMed, Google Scholar, Web Science, Embase databases using specific keywords related September 2023. Phytochemicals activate exert therapeutic effects AD. The these include inhibiting Aβ aggregation, preventing Tau hyperphosphorylation, inflammatory response glial activation, promoting autophagy, suppressing anti-oxidative stress. Additionally, AMPK-related pathways are involved mechanism, including AMPK/CaMKKβ/mTOR, AMPK/SIRT1/PGC-1α, AMPK/NF-κB/NLRP3, AMPK/mTOR, PERK/eIF2α pathways. Notably, urolithin A, artemisinin, justicidin berberine, stigmasterol, arctigenin, rutaecarpine agonists effects. Several may have potential applications treatment. Overall, phytochemical-based overcome barriers diseases.

Language: Английский

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Methylated urolithin A, mitigates cognitive impairment by inhibiting NLRP3 inflammasome and ameliorating mitochondrial dysfunction in aging mice

Neuropharmacology, Journal Year: 2024, Volume and Issue: 252, P. 109950 - 109950

Published: April 16, 2024

Language: Английский

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Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder

Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105808 - 105808

Published: July 22, 2024

Language: Английский

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Unraveling the interplay between meningitis and mitochondria: Etiology, pathogenesis, and therapeutic insights

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113985 - 113985

Published: Jan. 6, 2025

Language: Английский

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Diosmetin Delays In Vitro Aging of Porcine Oocytes by Improving Mitochondrial Function and Reducing Oxidative Stress

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 291 - 291

Published: Jan. 21, 2025

Oocyte quality is crucial for successful fertilization and subsequent embryonic development. Post-ovulatory aging leads to reduced oocyte impaired embryogenesis, representing an unavoidable challenge in terms of certain assisted reproductive techniques. Diosmetin (DIOS), a natural flavonoid found lemons, spearmint, spider moss, exhibits antioxidant, anti-inflammatory, anti-apoptotic properties. However, its effects on the mature porcine oocytes vitro remain unexplored. This study investigated impact DIOS aging. In IVM medium, fresh were cultured 44 h, while 68 h. Following addition varying concentrations (0.01, 0.1, 1 μM) DIOS-treated group was The results demonstrated that 0.1 μM significantly improved blastocyst rates cell counts, reactive oxygen species (ROS), elevated glutathione (GSH) levels, enhanced mitochondrial function, decreased markers autophagy (LC3B), apoptosis (annexin V), endoplasmic reticulum stress (CHOP), senescence (SA-β-Gal). Furthermore, treatment upregulated expression relevant genes compared aged group. These findings suggest effectively delays

Language: Английский

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Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT Pathological changes in the locus coeruleus‐norepinephrine (LC‐NE) neurons, major source of norepinephrine (NE, also known as noradrenaline) brain, are evident during early stages neurodegenerative diseases (ND). Research on both human and animal models have highlighted therapeutic potential targeting LC‐NE system to mitigate progression ND alleviate associated psychiatric symptoms. However, widespread degeneration presents a significant challenge for direct intervention ND. Recent advances regenerative cell therapy offer promising new strategies treatment. The regeneration from pluripotent stem cells (PSCs) could significantly broaden scope LC‐NE‐based therapies In this review, we delve into fundamental background physiological functions LC‐NE. Additionally, systematically examine evidence role neuropathology over recent years. Notably, focus significance PSCs‐derived its impact therapy. A deeper understanding further investigation function pave way practical effective treatments

Language: Английский

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Peroxisome proliferator-activated receptors (PPARs) agonists as promising neurotherapeutics

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108226 - 108226

Published: Jan. 1, 2025

Language: Английский

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Short-term swimming induces the enhancement of mitochondrial-, survival-, and proliferation-related proteins in the hippocampus of healthy aged mice without affecting behavior

Sport Sciences for Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

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Epigenetics and the neurodegenerative process

Epigenomics, Journal Year: 2024, Volume and Issue: 16(7), P. 473 - 491

Published: March 21, 2024

Neurological diseases are multifactorial, genetic and environmental. Environmental factors such as diet, physical activity emotional state epigenetic factors. markers responsible for modifications. The effect of changes is increased inflammation the nervous system neuronal damage. In recent years, it has been shown that may cause an risk neurological disorders but, currently, relationship between modifications neurodegeneration remains unclear. This review summarizes current knowledge about caused by in Alzheimer's disease, Parkinson's stroke epilepsy. Advances techniques be key to understanding epigenetics central diseases.

Language: Английский

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Genetic Heterogeneity Underlying Phenotypes with Early-Onset Cerebellar Atrophy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16400 - 16400

Published: Nov. 16, 2023

Cerebellar atrophy (CA) is a frequent neuroimaging finding in paediatric neurology, usually associated with cerebellar ataxia. The list of genes involved hereditary forms CA continuously growing and reveals its genetic complexity. We investigated ten cases early-onset involvement without ataxia by exome sequencing or targeted panel 363 spastic paraplegia. Novel variants were silico experimental approaches. Seven probands carry causative well-known hypoplasia: SETX, CACNA1G, CACNA1A, CLN6, CPLANE1, TBCD. remaining three deserve special attention; they harbour MAST1, PI4KA CLK2 genes. MAST1 responsible for an ultrarare condition characterised global developmental delay cognitive decline; our index case added to the concomitant symptoms. PIK4A mainly related hypomyelinating leukodystrophy; proband presented pure paraplegia normal intellectual capacity. Finally, patient who suffers from mild oculomotor apraxia, de novo novel c.1120T>C variant was found. protein expression mutated reduced, which may indicate instability that would affect kinase activity.

Language: Английский

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