Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 289, P. 117511 - 117511
Published: Dec. 10, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 484 - 484
Published: Jan. 8, 2025
Alzheimer's disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, neuroinflammation. Despite advancements in early detection, diagnosis, treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, the limited efficacy current therapies. Consequently, there is pressing need for novel therapeutic agents target multifaceted aspects enhance treatments, minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation. This review aimed evaluate effects AdipoRon-based replacement therapy against AD, using comprehensive approach grounded PICO framework-Population, Intervention, Comparison, Outcomes. A total six studies were reviewed, vitro vivo investigations examining AdipoRon's impact on various models. These involved different cell lines transgenic mouse models, assessing outcomes such as phosphorylation, relevant molecular pathways. By synthesizing data from these studies, our thoroughly explains mechanisms action, agent AD. analysis aims highlight state knowledge, identify gaps research, suggest directions future clinical applications.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694
Published: March 26, 2024
Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.
Language: Английский
Citations
12
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354
Published: Oct. 10, 2024
Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment
Language: Английский
Citations
8
Clinical Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 116(1), P. 72 - 81
Published: April 26, 2024
Fibroblast growth factor (FGF)-21 analogs are potential therapeutic candidates for metabolic dysfunction-associated steatohepatitis (MASH). This systematic review and meta-analysis aimed to assess the efficacy safety of FGF-21 analogs, efruxifermin, pegbelfermin, pegozafermin MASH treatment. A comprehensive randomized controlled trials from five major databases was conducted. Primary outcomes focused on liver histological improvement, while secondary encompassed reductions in fat content improvements biochemical parameters. Safety examined included treatment-emergent adverse events (TEAEs), treatment-related TEAEs, TEAEs leading discontinuation, serious TEAEs. Eight eligible studies involving 963 patients were this review. Compared with placebo group, analog-treated group exhibited significantly improved primary outcomes, specifically ≥1 stage improvement fibrosis no worsening (risk ratio [RR] = 1.83; 95% confidence interval [CI] 1.27-2.62) at least two-point non-alcoholic fatty disease activity score (RR 2.85; CI 2.06-3.95). Despite an increased risk 1.17; 1.08-1.27) 1.75; 1.40-2.19), acceptable profile. better achieving beneficial compared placebo, a tolerable pattern. These findings shed light provide valuable evidence their application as therapeutics.
Language: Английский
Citations
7
Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2129 - 2129
Published: Sept. 19, 2024
Adipose tissue was previously regarded as a dormant organ for lipid storage until the identification of adiponectin and leptin in early 1990s. This revelation unveiled dynamic endocrine function adipose tissue, which has expanded further. emerged recent decades multifunctional that plays significant role energy metabolism homeostasis. Currently, it is evident primarily performs its by secreting diverse array signaling molecules known adipokines. Apart from their pivotal expenditure regulation, these adipokines exert influence over multitude biological processes, including but not limited to inflammation, thermoregulation, immune response, vascular function, insulin sensitivity. Adipokines are regulating numerous processes within facilitating communication between various organs, brain, gut, pancreas, endothelial cells, liver, muscle, more. Dysregulated have been implicated several metabolic diseases, like obesity diabetes, well cardiovascular diseases. In this article, we attempted describe significance developing diseases highlight crosstalk tissues other organs.
Language: Английский
Citations
6
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 165 - 177
Published: Aug. 13, 2024
Language: Английский
Citations
4
Cell Reports Medicine, Journal Year: 2025, Volume and Issue: 6(1), P. 101884 - 101884
Published: Jan. 1, 2025
Highlights•RBP-4, FGF-21, adiponectin, and osteocalcin enhance risk prediction for SLD•Adiponectin shows the best predictive performance SLD•Elevated FGF-21 RBP-4 emphasize metabolic alcohol management, respectivelySummaryThe effectiveness of established biomarkers non-alcoholic fatty liver disease (NAFLD) within updated framework steatotic (SLD) remains uncertain. This cohort study examines association four biomarkers—retinol-binding protein 4 (RBP-4), fibroblast growth factor 21 (FGF-21), osteocalcin—with SLD its subtypes: dysfunction-associated (MASLD) dysfunction with alcohol-related (MetALD)/alcohol-related (ALD). Among 3,504 Chinese participants aged 55–70, 938 (26.8%) have developed over 5 years, including 871 MASLD 67 MetALD/ALD. The findings indicate that models incorporating RBP-4, improve accuracy beyond conventional models. Notably, adiponectin emerges as most versatile marker, while elevated baseline levels or specific needs interventions, respectively, supporting tailored precision medicine strategies.Graphical abstract
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1996 - 2004
Published: Jan. 1, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 602 - 602
Published: April 16, 2025
As part of chemotherapy regimens, Paclitaxel improves the overall survival many non-small cell lung cancer (NSCLC) patients. However, development drug resistance and adverse events limits its clinical usage, reinforcing need for further advancements in NSCLC therapeutics. We recently recognized adiponectin receptor agonist AdipoRon as a promising anticancer compound NSCLC. Consequently, this study aimed to evaluate therapeutic potential combining with (Combo) cells. With respect individual treatments, Combo triggered stronger inhibition both growth clonogenic potential, well greater induction death. The Combo-mediated cytotoxicity was also corroborated by cleavage poly-ADP ribose polymerase (PARP) caspase-3 apoptotic markers. Notably, AMP-activated protein kinase (AMPK) emerged critical sensor efficacy, Compound-C unveiled significant rescue growth. Although caused gradual downregulation extracellular signal-regulated 1/2 (ERK1/2), hindrance upstream cascade PD98059 partially counteracted outcomes. In conclusion, our findings designate an effective candidate Paclitaxel-based therapy. Nevertheless, future studies at exploring aptitude overcoming Paclitaxel-related restraints be investigated
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 612 - 612
Published: April 23, 2025
Cardiometabolic risk and associated dysfunctions contribute largely to the recent rise in mortality globally. Advancements multi-omics years promise a better understanding of potential biomarkers that enable an early diagnosis cardiometabolic dysfunction. However, molecular mechanisms driving onset progression disorders remain poorly understood. Adipokines are adipocyte-specific cytokines central deleterious alterations. They exhibit both pro-inflammatory anti-inflammatory effects, complicating their association with disturbances. Thus, adipokines from signaling perspective assumes great importance. This review presents comprehensive outline most prominent exhibiting and/or functions The also insight into pathophysiological implications such different dysfunction conditions, status adipokine druggability, future studies can be undertaken address existing scientific gap. A clear functional mechanistic role potentially improve our cardiovascular disease pathophysiology enhance current therapeutic regimen come.
Language: Английский
Citations
0