Adiponectin deficiency is a critical factor contributing to cognitive dysfunction in obese mice after sevoflurane exposure

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Oct. 16, 2024

Abstract Background The number of major operations performed in obese patients is expected to increase given the growing prevalence obesity. Obesity a risk factor for range postoperative complications including perioperative neurocognitive disorders. However, mechanisms underlying this vulnerability are not well defined. We hypothesize that subjects more vulnerable general anaesthesia induced neurotoxicity due reduced levels adiponectin. This hypothesis was tested using murine surgical model and adiponectin knockout mice exposed volatile anaesthetic agent sevoflurane. Methods Obese were bred by subjecting C57BL/6 high fat diet. Cognitive function, neuroinflammatory responses neuronal degeneration assessed both lean following exposure 2 h sevoflurane confirm sevoflurane-induced neurotoxicity. Thereafter, role deficiency in, established Finally, neuroprotective effects receptor agonist (AdipoRon) examined. Results Sevoflurane triggered significant cognitive dysfunction, while no impact observed mice. Similar dysfunction also after exposure. Administration AdipoRon partially prevented deleterious Conclusions Our findings demonstrate susceptible impairment which one mechanisms. Treatment with ameliorates vulnerability. These may have therapeutic implications reducing incidence related subjects.

Language: Английский

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Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(47), P. 5086 - 5091

Published: Nov. 25, 2024

Qu and Li emphasize a fundamental aspect of metabolic dysfunction-associated fatty liver disease in their manuscript, focusing on the critical need for non-invasive diagnostic tools to improve risk stratification predict progression severe complications. Affecting approximately 25% global population, is most common chronic condition, with higher prevalence among those obesity. This letter stresses importance early diagnosis intervention, especially given rising incidence obesity syndrome. Research advancements provide insight into potential biomarkers (particularly inflammation-related) as predictive treatment response. overview addresses pleiotropic linked inflammation cardiometabolic disorders, which may aid efficacy monitoring. Despite progress, significant knowledge gaps remain clinical application these biomarkers, necessitating further research establish standardized protocols validate utility practice. Understanding complex interactions factors opens new avenues enhance assessment, leading better patient outcomes addressing public health burden this worldwide condition.

Language: Английский

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Chickpea (Cicer arietinum) protein hydrolysate ameliorates metabolic effects of feeding a high-fat diet to mice

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 121, P. 106407 - 106407

Published: Aug. 15, 2024

Language: Английский

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Effect of goose-derived adiponectin peptide gADP3 on LPS-induced inflammatory injury in goose liver

British Poultry Science, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Sept. 9, 2024

1. This study evaluated the effects and mechanisms of action peptide gADP3 on hepatic inflammatory injury induced by lipopolysaccharide (LPS).2. Hepatic was in geese intraperitoneal injection LPS gADP3, adiponectin receptor agonist AdipoRon (positive control) used for potential amelioration. Serum factor levels, liver function-related biochemical indicators oxidative stress-related parameters tissues were determined. The expression levels its receptors, inflammation genes key signalling molecules involved adiponectin, stress pathways detected.3. alleviated cell infiltration changes, reversed decrease serum albumin (ALB), total protein (TP), alanine aminotransferase (ALT) aspartate (AST) content or activity increased antioxidant enzymes CAT (catalase), SOD (superoxide dismutase) GSH-Px (glutathione peroxidase).4. upregulated enzyme-related GCLC, HO-1 NQO1 tissues, decreased factors like TNF-α, IL-1β, IL-6, IFN-γ TGF-β reduced mRNA inflammatory-related iNOS TGF-β. Additionally, it as well pathway AMPK PPARα. In addition, changes pathway-related P38MAPK, NF-κBP65, TLR4 Nrf2 caused treatment.5. conclusion, goose-derived similar to AdipoRon, attenuated LPS-induced geese.

Language: Английский

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Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells—a systematic review

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Language: Английский

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The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression

Viruses, Journal Year: 2023, Volume and Issue: 16(1), P. 24 - 24

Published: Dec. 22, 2023

Zika virus (ZIKV) is a pathogenic member of the flavivirus family, with several unique characteristics. Unlike any other arbovirus, ZIKV can be transmitted sexually and maternally, thus produce congenital syndromes (CZS) due to its neurotropism. This challenges search for safe active molecules that protect pregnant women their fetuses. In this context, in absence existing treatment, it seemed worthwhile test whether known cytoprotective properties adiponectin pharmacological analog, AdipoRon, could influence outcome infection. We showed both AdipoRon significantly reduce vitro infection A549 epithelial cells, well-known cell model studies. effect was particularly observed when pre-treatment carried out. Conversely, revealed an ability downregulate receptor expression thereby limit signaling.

Language: Английский

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Adiponectin deficiency is a critical factor contributing to cognitive dysfunction in obese mice after sevoflurane exposure

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Background The growing number of obese individuals is expected to create an increase in the major operations be performed those patients. Obesity a risk factor for range postoperative complications including perioperative neurocognitive disorders. However, neurotoxic effects general anaesthesia subjects are not yet determined. We hypothesize that such as sevoflurane induces neurotoxicity animals while no significant impact induced lean mice. This vulnerability depends on reduction adiponectin Methods Obese mice were bred by subjecting C57BL/6 60% high fat diet. Both exposed 2 hours sevoflurane. To confirm role deficiency neurotoxicity, knockout established and Finally, neuroprotective receptor agonist (AdipoRon) examined. Cognitive functions, neuroinflammatory responses neuronal degeneration accessed. Results Sevoflurane triggered cognitive dysfunction, response was observed Similar dysfunction also after exposure. Administration AdipoRon prevented deleterious both Conclusions Our findings demonstrated more susceptible impairment compared with animals. Adiponectin one underlying mechanisms treatment ameliorates this vulnerability. These may have therapeutic implications reduce incidence subjects.

Language: Английский

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AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 289, P. 117511 - 117511

Published: Dec. 10, 2024

Language: Английский

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