Targeting mitochondria with small molecules: A promising strategy for combating Parkinson’s disease

Mitochondrion, Journal Year: 2024, Volume and Issue: unknown, P. 101971 - 101971

Published: Sept. 1, 2024

Language: Английский

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Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Language: Английский

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Reactions of Plasmodium falciparum Type II NADH: Ubiquinone Oxidoreductase with Nonphysiological Quinoidal and Nitroaromatic Oxidants

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2509 - 2509

Published: March 11, 2025

In order to detail the antiplasmodial effects of quinones (Q) and nitroaromatic compounds (ArNO2), we investigated their reduction mechanism by Plasmodium falciparum flavoenzyme type II NADH:ubiquinone oxidoreductase (PfNDH2). The reactivity Q ArNO2 (n = 29) follows a common trend exhibits parabolic dependence on single-electron potential (E71), albeit with significantly scattered data. similar E71 values increases lipophilicity. Quinones are reduced PfNDH2 in two-electron way, but way. inhibition studies using NAD+ ADP-ribose showed that oxidize complexes enzyme NADH NAD+. This suggests that, as case other NDH2s, nicotinamide ring NAD(H) bind at separate sites. A scheme catalysis is proposed, consistent both observed ‘ping-pong’ presence two substrate binding Molecular docking manner lipophilic have higher affinity for site. One may expect can be partially responsible previously enhanced activity aziridinylbenzoquinones caused reduction, well redox cycling oxidative stress-type action ArNO2.

Language: Английский

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Understanding the interplay of malarial pathogenesis, host immune response and oxidative stress: Implications for disease progression and therapeutic strategies

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100082 - 100082

Published: April 1, 2025

Language: Английский

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Formononetin exerts synergistic action with artesunate against multi-drug-resistant P. falciparum arresting ring-to-schizont transition by inducing reactive oxygen species

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(6)

Published: April 22, 2025

Language: Английский

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Molecular modelling and experimental validation identified a new therapeutic inhibitor of toxoplasmosis

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 183, P. 109236 - 109236

Published: Oct. 7, 2024

Language: Английский

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Mitochondria-targeting by small molecules against Alzheimer's disease: A mechanistic perspective

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1871(3), P. 167617 - 167617

Published: Dec. 8, 2024

Language: Английский

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Dobinin K Displays Antiplasmodial Activity through Disruption of Plasmodium falciparum Mitochondria and Generation of Reactive Oxygen Species

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4759 - 4759

Published: Oct. 8, 2024

Dobinin K is a novel eudesmane sesquiterpenoids compound isolated from the root of

Language: Английский

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Design and synthesis of a Thymol dimer with antioxidant properties for the prevention of iron-mediated protein degradation

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: unknown, P. 101516 - 101516

Published: Dec. 1, 2024

Language: Английский

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