Pantothenic acid-mediated inhibition of microglial inflammation via the JAK2/STAT3 pathway enhances motor function recovery after Spinal cord injury DOI Creative Commons

Yuepeng Fang,

Ce Zhang,

Zhijie Yang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Abstract This study employed transcriptome sequencing and targeted metabolomics to delve into the molecular alterations in mouse spinal cords following cord injury (SCI). Notably, a significant depletion of pantothenic acid (PA) was observed injured cord, exhibiting an inverse correlation with microglial inflammation activation. To further elucidate this relationship, experimental interventions using PA were conducted SCI models. The results demonstrated that administration effectively inhibited via modulation JAK2/STAT3 signaling pathway. inhibition not only mitigated neuroinflammatory milieu but also fostered environment conducive axonal growth neuronal regeneration. Consequently, mice treated exhibited improved motor function recovery compared untreated controls. Our findings deepen understanding relationship between processes highlight therapeutic potential promoting regeneration functional recovery.

Language: Английский

Interleukin-6 serves as a critical factor in various cancer progression and therapy DOI
Asma’a H. Mohamed, Abdulrahman T. Ahmed, Waleed Al Abdulmonem

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(7)

Published: June 20, 2024

Language: Английский

Citations

13
Neutrophil diversity and function in health and disease DOI Creative Commons

F Zhang,

Yidan Xia,

Jiayang Su

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 5, 2024

Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.

Language: Английский

Citations

6
Formononetin Affects Polarization of M2 Macrophages Through the Jak2/Stat3 Pathway in Hcc DOI

Yan Zhuang,

Shouhong Gao, Yichao Yan

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeting NEK Kinases in Gastrointestinal Cancers: Insights into Gene Expression, Function, and Inhibitors DOI Open Access
Lei Chen, Heng Lu, Farah Ballout

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1992 - 1992

Published: Feb. 25, 2025

Gastrointestinal (GI) cancers, which mainly include malignancies of the esophagus, stomach, intestine, pancreas, liver, gallbladder, and bile duct, pose a significant global health burden. Unfortunately, prognosis for most GI cancers remains poor, particularly in advanced stages. Current treatment options, including targeted immunotherapies, are less effective compared to those other cancer types, highlighting an urgent need novel molecular targets. NEK (NIMA related kinase) kinases group serine/threonine (NEK1-NEK11) that play role regulating cell cycle, mitosis, various physiological processes. Recent studies suggest several members overexpressed human gastrointestinal can contribute tumor progression drug resistance. Among these, NEK2 stands out its consistent overexpression all types cancer. Targeting with specific inhibitors has shown promising results preclinical studies, gastric pancreatic cancers. The development clinical evaluation have emerged as therapeutic strategy. Specifically, inhibitor, T-1101 tosylate, is currently undergoing trials. This review will focus on gene expression functional roles NEKs well progress developing inhibitors.

Language: Английский

Citations

0
Unveiling the Role of JAK2/STAT3 Signaling in Chemoresistance of Gynecological Cancers: From Mechanisms to Therapeutic Implications DOI
Tianxiao Zhang,

Chang Xiaohan

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104712 - 104712

Published: April 1, 2025

Language: Английский

Citations

0
CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availability DOI Creative Commons
Xin Li, Zhe Zhao,

Hongping Ye

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Inflammatory pathways are often hijacked by cancer cells to favor their own proliferation and survival. Cysteine dioxygenase type 1 (CDO1), an iron-dependent thiol enzyme, catalyzes the rate-limiting step for cysteine oxidation, so that functions as important regulator of cellular availability. However, whether inflammatory environment affects CDO1 activity oxidation its potential impact on tumor growth remains substantially elusive. In present study, we demonstrate is inhibited upon IL-6 treatment, without noticeable alterations in expression. Mechanistically, AKT1 phosphorylates T89 under which represses enzymatic disrupting iron incorporation. Further, AKT1-mediated phosphorylation required IL-6-elicited oral squamous cell carcinoma (OSCC) growth, associated with progression OSCC development. The data discover a new mechanism governs support thereby highlighting value anti-tumor target.

Language: Английский

Citations

0
Oxidative stress-induced CDO1 glutathionylation regulates cysteine metabolism and sustains redox homeostasis under ionizing radiation DOI Creative Commons
Yumin He, Dan Li,

Hongping Ye

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103656 - 103656

Published: April 1, 2025

Language: Английский

Citations

0
Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 / PINK 1-Parkin / EMT DOI
Yun‐Jie Wei, Qiqi Li,

Kaiye He

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 224, P. 447 - 456

Published: Aug. 29, 2024

Language: Английский

Citations

1
The Immune Response of Cancer Cells in Breast and Gynecologic Neoplasms DOI Open Access
Katarzyna Rakoczy, Justyna Kaczor, Adam Sołtyk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6206 - 6206

Published: June 5, 2024

Cancer diseases constitute a major health problem which leads to the death of millions people annually. They are unique among other because cancer cells can perfectly adapt environment that they create themselves. This is usually highly hostile and for normal it would be hugely difficult survive, however neoplastic not only survive but also manage proliferate. One reasons alter immunological pathways allow them flexible change their phenotype one needed in specific conditions. The aim this paper describe some these play significant roles gynecologic neoplasms as well review recent research field. It high importance possess extensive knowledge about processes, greater understanding creating more specialized therapies may prove effective future.

Language: Английский

Citations

0
Crosstalk between circular RNAs and the STAT3 signaling pathway in human cancer DOI

Mansour Almouh,

Chadi Soukkarieh, Morshed Kassouha

et al.

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Journal Year: 2024, Volume and Issue: 1867(4), P. 195051 - 195051

Published: Aug. 8, 2024

Language: Английский

Citations

0