Roles of ferroptosis in the development of diabetic nephropathy DOI
Pan Liu, Zhengdong Zhang, Chen Qiu

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: 53(6), P. 708 - 714

Published: Dec. 1, 2024

Diabetic nephropathy is a common microvascular complication of diabetes mellitus and one the main causes death in patients with mellitus. Ferroptosis newly discovered iron-dependent regulated cell death, which may contribute to pathogenesis development diabetic nephropathy. Adenosine monophosphate-activated protein kinase (AMPK)-mediated ferroptosis-related signaling pathways can slow down progression nephropathy, but excessive activation AMPK pathway induce cells undergo autophagic death. Activation mediated by nuclear factor-erythroid 2-related factor (Nrf) 2 heme oxygenase (HO)-1 inhibit ferroptosis alleviate However, regulatory effect HO-1 on bidirectional, HIF-1α/HO-1 lead intracellular iron overload ultimately promote ferroptosis. Transforming growth (TGF)-β1 accelerate lipid peroxidation down-regulating levels SLC7A11/GSH/GPX4. The exosome lncRNAs/circRNAs/miRNAs are also involved In addition, stimulator interferon gene (STING) novel promoter acyl-CoA synthetase long-chain family (ACSL) 1 this review, we focus roles through AMPK, Nrf2/HO-1, TGF-β exosomes, elaborate potential therapeutic target for

Language: Английский

A new strategy for Astragaloside IV in the treatment of diabetic kidney disease: Analyzing the regulation of ferroptosis and mitochondrial function of renal tubular epithelial cells DOI
Jun Liu, Kang Yang,

Linlan Zhou

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112794 - 112794

Published: Aug. 12, 2024

Language: Английский

Citations

4
Targeting Ferroptosis and Ferritinophagy Improves Tooth Extraction Socket Healing in Type 2 Diabetes Mellitus Via Human Bone Marrow Mesenchymal Stem Cells Modulation DOI
Yifeng Bian, Jianfeng Li, Fan Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications DOI Creative Commons
Jinyang Wang, Haonan Shi, Ye Seul Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Diabetic kidney disease (DKD) is a prevalent complication of diabetes mellitus (DM), and its incidence increasing alongside the number cases. Effective treatment long-term management DKD present significant challenges; thus, deeper understanding pathogenesis essential to address this issue. Chronic inflammation abnormal cell death in closely associate with development. Recently, there has been considerable attention focused on immune infiltration into renal tissues inflammatory response’s role progression. Concurrently, ferroptosis—a novel form death—has emerged as critical factor pathogenesis, leading increased glomerular filtration permeability, proteinuria, tubular injury, interstitial fibrosis, other pathological processes. The cardiorenal benefits SGLT2 inhibitors (SGLT2-i) patients have demonstrated through numerous large clinical trials. Moreover, further exploratory experiments indicate these drugs may ameliorate serum urinary markers inflammation, such TNF-α, inhibit ferroptosis models. Consequently, investigating interplay between innate responses for guiding future drug This review presents an overview within context DKD, beginning core mechanisms delving potential roles We will also analyze how aberrant cells, molecules, signaling pathways contribute Finally, we discuss interactions responses, well targeted therapeutic agents, based current evidence. By analyzing immunity aim provide insights development area.

Language: Английский

Citations

0
Iron Metabolism and Ferroptosis in Diabetic Kidney Disease DOI

Fangxin Mu,

Ping Luo, Yuexin Zhu

et al.

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(4)

Published: April 1, 2025

ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies

Language: Английский

Citations

0
Fabry disease podocytes reveal ferroptosis as a potential regulator of cell pathology DOI Creative Commons
Andrea F. Wise,

Igaa Ari Krisnadevi,

Shoni Bruell

et al.

Kidney International Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets DOI
Yanxin Yu, Lei Zhang, Die Zhang

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Language: Английский

Citations

1
The role of cGAS-STING signaling pathway in ferroptosis DOI Creative Commons
Lina Ding, R Zhang,

Wenqi Du

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence lipid peroxidation, represents specialized form cell death. A burgeoning collection studies demonstrated that the cGAS-STING participates homeostatic regulation organism modulating ferroptosis-associated enzyme activity or gene expression. Consequently, elucidating specific roles STING ferroptosis vivo is vital for targeted disease intervention. This review systematically examines interactions between ferroptosis, highlighting their influence on progression contexts inflammation, injury, cancerous dynamics. Understanding these may provide novel therapeutic strategies. implicated various death mechanisms, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis. Our focus primarily addresses role diseases, limiting discussion other modalities precluding comprehensive overview pathway's additional functions.

Language: Английский

Citations

0
Roles of ferroptosis in the development of diabetic nephropathy DOI
Pan Liu, Zhengdong Zhang, Chen Qiu

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: 53(6), P. 708 - 714

Published: Dec. 1, 2024

Diabetic nephropathy is a common microvascular complication of diabetes mellitus and one the main causes death in patients with mellitus. Ferroptosis newly discovered iron-dependent regulated cell death, which may contribute to pathogenesis development diabetic nephropathy. Adenosine monophosphate-activated protein kinase (AMPK)-mediated ferroptosis-related signaling pathways can slow down progression nephropathy, but excessive activation AMPK pathway induce cells undergo autophagic death. Activation mediated by nuclear factor-erythroid 2-related factor (Nrf) 2 heme oxygenase (HO)-1 inhibit ferroptosis alleviate However, regulatory effect HO-1 on bidirectional, HIF-1α/HO-1 lead intracellular iron overload ultimately promote ferroptosis. Transforming growth (TGF)-β1 accelerate lipid peroxidation down-regulating levels SLC7A11/GSH/GPX4. The exosome lncRNAs/circRNAs/miRNAs are also involved In addition, stimulator interferon gene (STING) novel promoter acyl-CoA synthetase long-chain family (ACSL) 1 this review, we focus roles through AMPK, Nrf2/HO-1, TGF-β exosomes, elaborate potential therapeutic target for

Language: Английский

Citations

0