Progress of tanshinone IIA against respiratory diseases: therapeutic targets and potential mechanisms

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

The respiratory system stands as one of the eight pivotal systems within human body, responsible for a range essential functions. Primarily, it facilitates absorption oxygen from external environment and expulsion carbon dioxide, thereby playing crucial role in regulating body's acid-base balance. Furthermore, helps to maintain stability internal environment, ensuring smooth progression normal metabolic processes sustaining life activities. In wake novel coronavirus pneumonia outbreak, diseases have continued exhibit comparatively high morbidity mortality rates, underscoring urgent need discovery therapeutic agents. Tanshinone IIA (Tan IIA), bioactive chemical constituent derived Salvia miltiorrhiza Bunge, has emerged promising candidate. As significant fat-soluble compound, Tan traditionally been utilized treatment cardiovascular diseases. research on progressed, its multifaceted potential unveiled. Specifically, demonstrated anti-inflammatory, anti-oxidative stress, anti-fibrosis, anti-cancer effects. recent years, wealth studies concentrated elucidating impact various diseases, including asthma, chronic obstructive pulmonary disease, hypertension, fibrosis, acute lung injury/acute distress syndrome, cancer. These findings collectively suggest that holds considerable promise realm anti-respiratory disease therapies. present article undertakes comprehensive review targets mechanisms against offering valuable insights can serve reference future endeavors clinical applications ailments.

Language: Английский

Tanshinone IIA affects the proliferation of A549/Tax by affecting the expression of MMP7 through the PI3K-AKT-mTOR signaling pathway

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 20, 2025

This study aims to explore whether tanshinone IIA can act on paclitaxel-resistant non-small cell lung cancer A549/Tax and analyze the possible mechanisms involved. Using Cell Counting Kit-8 (CCK-8), we preliminarily analyzed has an inhibitory effect cells. We utilized public datasets, self-collected transcriptome drug target analysis identify potential targets. employed real-time fluorescent quantitative polymerase chain reaction (RT-qPCR) detect expression of core genes before after treatment validated them using data from The Cancer Genome Atlas (TCGA). conducted enrichment co-expressed mechanisms. Furthermore, molecular docking western blot verify CCK8 results indicated that a significant qPCR TCGA MMP7 is gene. Enrichment suggested PI3K-AKT signaling pathway might play key role. Molecular strong binding activity with PI3K, AKT, mTOR, MMP7. Western blotting showed inhibit through PI3K-AKT-mTOR pathway. Tanshinone may affect proliferation by influencing

Language: Английский

SREBP2 as a central player in cancer progression: potential for targeted therapeutics

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Recent studies have identified the reprogramming of lipid metabolism as a critical hallmark malignancy. Enhanced cholesterol uptake and increased biosynthesis significantly contribute to rapid growth tumors, with also playing essential roles in cellular signaling pathways. Targeting has emerged promising therapeutic strategy oncology. The sterol regulatory element-binding protein-2 (SREBP2) serves primary transcriptional regulator genes involved is crucial for maintaining homeostasis. Numerous reported upregulation SREBP2 across various cancers, facilitating tumor progression. This review aims provide comprehensive overview structure, biological functions, mechanisms SREBP2. Furthermore, we summarize that plays role cancers microenvironment primarily by regulating cholesterol, well through several non-cholesterol We particularly emphasize agents targeting are currently under investigation. seeks enhance our understanding SREBP2's involvement cancer theoretical references therapies target

Language: Английский