Role of Kynurenine and Its Derivatives in Liver Diseases: Recent Advances and Future Clinical Perspectives

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 968 - 968

Published: Jan. 24, 2025

Liver health is integral to overall human well-being and the pathogenesis of various diseases. In recent years, kynurenine its derivatives have gradually been recognized for their involvement in pathophysiological processes, especially regulation liver diseases, such as acute injury, non-alcoholic fatty disease, cirrhosis, cancer. Kynurenine are derived from tryptophan, which broken down by enzymes indoleamine 2,3-dioxygenase (IDO) tryptophan (TDO), converting essential amino acid into (KYN) other downstream metabolites, kynurenic (KYNA), 3-hydroxykynurenine (3-HK), xanthurenic (XA), quinolinic (QA). can promote activity transcription factor aryl hydrocarbon receptor (AhR), suppress T cell immune modulation, inhibit activation inflammatory signaling pathways, NF-κB anti-inflammatory effects, hepatic stellate cells slow fibrosis progression. Additionally, metabolites influence progression diseases modulating gut microbiota. Therefore, this review, we summarize explore mechanisms regulate help develop new diagnostic or prognostic biomarkers effective therapies targeting pathway disease treatment.

Language: Английский

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Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156623 - 156623

Published: March 10, 2025

Language: Английский

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The convergence of food science and nutrigenomics: Exploring new frontiers in innovation and development opportunities

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104975 - 104975

Published: March 1, 2025

Language: Английский

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Parabacteroides johnsonii Inhibits the Onset and Progression of Colorectal Cancer by Modulating the Gut Microbiota

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Background Colorectal cancer (CRC) is the third most prevalent malignant tumor and second leading cause of cancer-related deaths globally. The genus Parabacteroides an important component gut microbiota. P. distasonis goldsteinii are reported probiotics, their roles in CRC have been investigated related studies. However, association between johnsonii remains unknown. Methods (10–42) Lactococcus formosensis (22–2) were isolated from healthy human feces. 25 mice that demonstrated normal feeding activity randomly assigned to four groups : control (NC group), model (IC (PJ L. (LO group). Colonic tissues IC, PJ, LO colon NC group then collected for HE staining immunohistochemical staining. Fecal samples during hyperproliferative adenoma phases Metagenomic sequencing metabolite analysis. Results intervention reduced number slowed growth colonic tumors, improved histological scores, decreased microenvironmental inflammation levels. composition intestinal flora with cancer, increased microbial species diversity, maintained microbiota stability. Furthermore, abundance Bifidobacterium pseudolongum Lactobacillus, which play a role ameliorating AOM/DSS-induced dysbiosis. affected metabolic pathways, including amino sugar degradation galactose metabolism, sphingolipid synthesis, acid polyphenol synthesis tryptophan metabolism pathway as primary being affected. Conclusion Our study profiled administration reduces tumors lower staging by modulating its metabolites at early stages.

Language: Английский

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Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Obesity is a chronic metabolic disease, mainly caused by excessive/abnormal fat accumulation, as well accompanied endotoxemia and inflammation. Quercetin, natural flavonoid, may alleviate obesity regulating gut microbiota metabolites, but its exact mechanism for improving unknown. The aim of this study was to investigate the effects quercetin on high-fat diet (HFD)-induced in mice. In particular, we focused regulatory tryptophan metabolite indole-3-propionic acid (IPA). C57BL/6J mice were subjected 20-week HFD feeding regimen with concurrent daily oral administration or IPA. body weight, barrier function, inflammation determined. Gut composition analyzed 16S rRNA sequencing IPA levels measured serum feces. vitro experiments, Caco-2 cells used evaluate fecal dilutions from quercetin-treated tight junction protein expression aryl hydrocarbon receptor (AhR) activation. Our results revealed that supplementation significantly mitigated inflammation, improved disrupted function through actvation AhR/interleukin 22 (IL-22) pathway. treatment increased abundance Lactobacillus. Quercetin intervention feces alleviated enhanced intestinal AhR findings further corroborated cell experiment, which indicated modulation dysregulated change microbial coordinated improvement effect disruption. alleviates restoring induced disorder, elevates level activate AhR/IL-22 pathway, thereby enhancing integrity suppressing

Language: Английский

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Effectively Enhancing the Physiological Activity and Sensory Quality of Whole Calamondin Puree via Yeast Fermentation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11984 - 11984

Published: Nov. 7, 2024

To explore the feasibility of pure yeast fermentation in whole Calamondin puree (FWCP) for utilization fruit, yeasts were isolated from naturally fermented Calamondin, and their characteristics evaluated. The results indicated that all able to ferment FWCP, reducing sour taste by degrading citric acid, increasing contents nutrients (such as phenols limonins) volatile compounds, enhancing antioxidant activity inhibition α-glucosidase (

Language: Английский

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