Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism DOI Creative Commons
Alvaro C. Lima,

Vinícius S. Bioni,

Marcela Becegato

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Parkinson's disease (PD) is characterized by motor and non-motor symptoms such as tremors, difficulty in initiating movements, depression, cognitive deficits. The pathophysiology of PD involves a gradual decrease dopaminergic neurons the substantia nigra, increased inflammatory parameters, augmented oxidative stress this region. Several new therapies aim to promote antioxidant anti-inflammatory actions, including use cannabinoids, particularly cannabidiol (CBD). CBD non-psychotomimetic component Cannabis sativa that acts broadly through several mechanisms. objective study was investigate potential protective effect mice subjected low-dose (0.1 mg/kg) repeated reserpine protocol, which encompasses behavioral neuronal alterations compatible with progressiveness alterations. We used two approaches: (1) concurrent administration during development parkinsonism (2) pre-administration explore possible preventive action. (0.5 on reserpine-induced investigated (catalepsy vacuous chewing movements) (immunolabeling for tyrosine hydroxylase - TH) parameters. Overall, groups were treated presented later protocol compared received only (except evaluation concomitant treatment). Additionally, attenuated catalepsy (preventive treatment) prevented TH labeling nigra pars compacta both protocols. Based these data, we observed beneficial progressive parkinsonism, after treatment.

Language: Английский

Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism DOI Creative Commons
Alvaro C. Lima,

Vinícius S. Bioni,

Marcela Becegato

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Parkinson's disease (PD) is characterized by motor and non-motor symptoms such as tremors, difficulty in initiating movements, depression, cognitive deficits. The pathophysiology of PD involves a gradual decrease dopaminergic neurons the substantia nigra, increased inflammatory parameters, augmented oxidative stress this region. Several new therapies aim to promote antioxidant anti-inflammatory actions, including use cannabinoids, particularly cannabidiol (CBD). CBD non-psychotomimetic component Cannabis sativa that acts broadly through several mechanisms. objective study was investigate potential protective effect mice subjected low-dose (0.1 mg/kg) repeated reserpine protocol, which encompasses behavioral neuronal alterations compatible with progressiveness alterations. We used two approaches: (1) concurrent administration during development parkinsonism (2) pre-administration explore possible preventive action. (0.5 on reserpine-induced investigated (catalepsy vacuous chewing movements) (immunolabeling for tyrosine hydroxylase - TH) parameters. Overall, groups were treated presented later protocol compared received only (except evaluation concomitant treatment). Additionally, attenuated catalepsy (preventive treatment) prevented TH labeling nigra pars compacta both protocols. Based these data, we observed beneficial progressive parkinsonism, after treatment.

Language: Английский

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