Biopolymeric Scaffolds with Melatonin for Tissue Engineering—A Review DOI Open Access

Beata Kaczmarek,

Sylwia Grabska-Zielińska

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2520 - 2520

Published: March 11, 2025

Melatonin, a natural hormone with antioxidant, anti-inflammatory, and regenerative properties, has gained increasing attention in tissue engineering for its ability to enhance the therapeutic potential of biopolymeric scaffolds. These scaffolds, designed mimic extracellular matrix, provide structural support bioactive environment regeneration. By integrating melatonin, researchers aim create multifunctional scaffolds that promote cell proliferation, modulate inflammatory responses, improve wound healing outcomes. Challenges utilizing melatonin include maintaining stability under light, heat, oxygen exposure, optimizing release profile sustained effects. Innovative fabrication methods, such as electrospinning, 3D printing, lyophilization, have enabled precise control over scaffold architecture delivery. techniques ensure enhanced interactions target tissues tailored regeneration processes. Combining growth factors, cytokines, antimicrobial agents offers applications, from chronic management bone nerve Continued research this field promises transformative solutions medicine, expanding clinical applicability melatonin-enriched This review highlights current progress, challenges, opportunities associated harnessing melatonin’s within frameworks.

Language: Английский

The Effects of Self-Polymerized Polydopamine Coating on Mechanical Properties of Polylactic Acid (PLA)–Kenaf Fiber (KF) in Fused Deposition Modeling (FDM) DOI Open Access
Sanusi Hamat, M. R. Ishak,

Mohd Sapuan Salit

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(11), P. 2525 - 2525

Published: May 30, 2023

This research examines the impact of self-polymerized polydopamine (PDA) coating on mechanical properties and microstructural behavior polylactic acid (PLA)/kenaf fiber (KF) composites in fused deposition modeling (FDM). A biodegradable FDM model natural fiber-reinforced composite (NFRC) filaments, coated with dopamine reinforced 5 to 20 wt.% bast kenaf fibers, was developed for 3D printing applications. Tensile, compression, flexural test specimens were printed, influence content their assessed. comprehensive characterization blended pellets printed materials performed, encompassing chemical, physical, microscopic analyses. The results demonstrate that acted as a coupling agent, enhancing interfacial adhesion between fibers PLA matrix leading improved properties. An increase density porosity observed PLA-PDA-KF composites, proportional content. enhanced bonding particles contributed an up 13.4% tensile 15.3% Young's modulus 30% compressive stress. incorporation agent filament led improvement tensile, compressive, stresses strain at break, surpassing pure PLA, while reinforcement provided by more delayed crack growth, resulting higher break. coatings exhibit remarkable properties, suggesting potential sustainable material diverse applications FDM.

Language: Английский

Citations

13

Development of Bioactive Scaffolds for Orthopedic Applications by Designing Additively Manufactured Titanium Porous Structures: A Critical Review DOI Creative Commons

Mikhail Kiselevskiy,

N. Yu. Anisimova,

Alexei V. Kapustin

et al.

Biomimetics, Journal Year: 2023, Volume and Issue: 8(7), P. 546 - 546

Published: Nov. 13, 2023

We overview recent findings achieved in the field of model-driven development additively manufactured porous materials for a new generation bioactive implants orthopedic applications. Porous structures produced from biocompatible titanium alloys using selective laser melting can present promising material to design scaffolds with regulated mechanical properties and capacity be loaded pharmaceutical products. Adjusting pore geometry, one could control elastic modulus strength/fatigue engineered compatible bone tissues, thus preventing stress shield effect when replacing diseased fragment. Adsorption medicals by internal spaces would make it possible emit antibiotic anti-tumor agents into surrounding tissues. The developed porosity surface roughness provide desired vascularization osteointegration. critically analyze advances featuring model approaches, virtual testing designed structures, capabilities additive printing biomedical issues scaffolds, so on. Special attention is paid highlighting actual problems ways their solutions.

Language: Английский

Citations

12

The effect of increasing temperature on simulated nanocomposites reinforced with SWBNNs and its effect on characteristics related to mechanics and the physical attributes using the MDs approach DOI Creative Commons

Somayeh Tavasolikejani,

Ashkan Farazin

Heliyon, Journal Year: 2023, Volume and Issue: 9(10), P. e21022 - e21022

Published: Oct. 1, 2023

This study examines the effect of increasing temperature (300, 350, 400, 450 and 500 K) on simulated nanocomposites reinforced with exploration impact single-walled boron nitride nanotubes (SWBNNTs) both mechanical properties (including Young's modulus, Poisson's ratio, shear bulk modulus) physical property density, achieved through molecular dynamics (MDs) simulations. MDs utilized to simulate nanocomposite models consisting five case studies SWBNNs different chiralities (5, 0), (10, (15, (20, (25, 0) as reinforcement using thermoplastic polyurethane (TPU) common matrix. The results reveal that SWBNNTs, density ratio increase dramatically, Young's, shear, moduli decrease continuously. At a consistent temperature, there is noteworthy trend in SWBNNTs various chiralities. includes modulus nanocomposite, ranging from 0). Similarly, exhibits an then decreases at To validate accuracy these findings, Radial Distribution Function (RDF) diagram generated Materials Studio software.

Language: Английский

Citations

11

Bioprinting: Mechanical Stabilization and Reinforcement Strategies in Regenerative Medicine DOI

Ashleigh Ballard,

Rebecca Patush,

Jenesis Perez

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(13-14), P. 387 - 408

Published: Jan. 11, 2024

Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with various combinations embedded bioactive molecules. It encompasses precise patterning cells to create scaffolds for different biomedical needs. There are many requirements that bioprinting face, it is ultimately interplay between scaffold's structure, properties, processing, performance will lead its successful translation. Among essential properties must possess—adequate appropriate application-specific chemical, mechanical, biological performance—the mechanical behavior hydrogel-based bioprinted key their stable in vivo at site implantation. Hydrogels typically constitute main scaffold material medium biomolecules very soft, often lack sufficient stability, which reduces printability and, therefore, potential. The aim this review article highlight reinforcement strategies used approaches achieve enhanced stability bioinks printed scaffolds. Enabling robust materials processes creation truly complex remarkable structures could accelerate application smart, functional settings. a powerful tool fabrication 3D applications. has gained tremendous attention recent years, bioink library expanding include more combinations. From practical perspective, need be considered, such as structure's performances. these, constructs critical translation into clinic. explore stabilization structures.

Language: Английский

Citations

4

Biopolymeric Scaffolds with Melatonin for Tissue Engineering—A Review DOI Open Access

Beata Kaczmarek,

Sylwia Grabska-Zielińska

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2520 - 2520

Published: March 11, 2025

Melatonin, a natural hormone with antioxidant, anti-inflammatory, and regenerative properties, has gained increasing attention in tissue engineering for its ability to enhance the therapeutic potential of biopolymeric scaffolds. These scaffolds, designed mimic extracellular matrix, provide structural support bioactive environment regeneration. By integrating melatonin, researchers aim create multifunctional scaffolds that promote cell proliferation, modulate inflammatory responses, improve wound healing outcomes. Challenges utilizing melatonin include maintaining stability under light, heat, oxygen exposure, optimizing release profile sustained effects. Innovative fabrication methods, such as electrospinning, 3D printing, lyophilization, have enabled precise control over scaffold architecture delivery. techniques ensure enhanced interactions target tissues tailored regeneration processes. Combining growth factors, cytokines, antimicrobial agents offers applications, from chronic management bone nerve Continued research this field promises transformative solutions medicine, expanding clinical applicability melatonin-enriched This review highlights current progress, challenges, opportunities associated harnessing melatonin’s within frameworks.

Language: Английский

Citations

0