International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2520 - 2520
Published: March 11, 2025
Melatonin,
a
natural
hormone
with
antioxidant,
anti-inflammatory,
and
regenerative
properties,
has
gained
increasing
attention
in
tissue
engineering
for
its
ability
to
enhance
the
therapeutic
potential
of
biopolymeric
scaffolds.
These
scaffolds,
designed
mimic
extracellular
matrix,
provide
structural
support
bioactive
environment
regeneration.
By
integrating
melatonin,
researchers
aim
create
multifunctional
scaffolds
that
promote
cell
proliferation,
modulate
inflammatory
responses,
improve
wound
healing
outcomes.
Challenges
utilizing
melatonin
include
maintaining
stability
under
light,
heat,
oxygen
exposure,
optimizing
release
profile
sustained
effects.
Innovative
fabrication
methods,
such
as
electrospinning,
3D
printing,
lyophilization,
have
enabled
precise
control
over
scaffold
architecture
delivery.
techniques
ensure
enhanced
interactions
target
tissues
tailored
regeneration
processes.
Combining
growth
factors,
cytokines,
antimicrobial
agents
offers
applications,
from
chronic
management
bone
nerve
Continued
research
this
field
promises
transformative
solutions
medicine,
expanding
clinical
applicability
melatonin-enriched
This
review
highlights
current
progress,
challenges,
opportunities
associated
harnessing
melatonin’s
within
frameworks.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2525 - 2525
Published: May 30, 2023
This
research
examines
the
impact
of
self-polymerized
polydopamine
(PDA)
coating
on
mechanical
properties
and
microstructural
behavior
polylactic
acid
(PLA)/kenaf
fiber
(KF)
composites
in
fused
deposition
modeling
(FDM).
A
biodegradable
FDM
model
natural
fiber-reinforced
composite
(NFRC)
filaments,
coated
with
dopamine
reinforced
5
to
20
wt.%
bast
kenaf
fibers,
was
developed
for
3D
printing
applications.
Tensile,
compression,
flexural
test
specimens
were
printed,
influence
content
their
assessed.
comprehensive
characterization
blended
pellets
printed
materials
performed,
encompassing
chemical,
physical,
microscopic
analyses.
The
results
demonstrate
that
acted
as
a
coupling
agent,
enhancing
interfacial
adhesion
between
fibers
PLA
matrix
leading
improved
properties.
An
increase
density
porosity
observed
PLA-PDA-KF
composites,
proportional
content.
enhanced
bonding
particles
contributed
an
up
13.4%
tensile
15.3%
Young's
modulus
30%
compressive
stress.
incorporation
agent
filament
led
improvement
tensile,
compressive,
stresses
strain
at
break,
surpassing
pure
PLA,
while
reinforcement
provided
by
more
delayed
crack
growth,
resulting
higher
break.
coatings
exhibit
remarkable
properties,
suggesting
potential
sustainable
material
diverse
applications
FDM.
Biomimetics,
Journal Year:
2023,
Volume and Issue:
8(7), P. 546 - 546
Published: Nov. 13, 2023
We
overview
recent
findings
achieved
in
the
field
of
model-driven
development
additively
manufactured
porous
materials
for
a
new
generation
bioactive
implants
orthopedic
applications.
Porous
structures
produced
from
biocompatible
titanium
alloys
using
selective
laser
melting
can
present
promising
material
to
design
scaffolds
with
regulated
mechanical
properties
and
capacity
be
loaded
pharmaceutical
products.
Adjusting
pore
geometry,
one
could
control
elastic
modulus
strength/fatigue
engineered
compatible
bone
tissues,
thus
preventing
stress
shield
effect
when
replacing
diseased
fragment.
Adsorption
medicals
by
internal
spaces
would
make
it
possible
emit
antibiotic
anti-tumor
agents
into
surrounding
tissues.
The
developed
porosity
surface
roughness
provide
desired
vascularization
osteointegration.
critically
analyze
advances
featuring
model
approaches,
virtual
testing
designed
structures,
capabilities
additive
printing
biomedical
issues
scaffolds,
so
on.
Special
attention
is
paid
highlighting
actual
problems
ways
their
solutions.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(10), P. e21022 - e21022
Published: Oct. 1, 2023
This
study
examines
the
effect
of
increasing
temperature
(300,
350,
400,
450
and
500
K)
on
simulated
nanocomposites
reinforced
with
exploration
impact
single-walled
boron
nitride
nanotubes
(SWBNNTs)
both
mechanical
properties
(including
Young's
modulus,
Poisson's
ratio,
shear
bulk
modulus)
physical
property
density,
achieved
through
molecular
dynamics
(MDs)
simulations.
MDs
utilized
to
simulate
nanocomposite
models
consisting
five
case
studies
SWBNNs
different
chiralities
(5,
0),
(10,
(15,
(20,
(25,
0)
as
reinforcement
using
thermoplastic
polyurethane
(TPU)
common
matrix.
The
results
reveal
that
SWBNNTs,
density
ratio
increase
dramatically,
Young's,
shear,
moduli
decrease
continuously.
At
a
consistent
temperature,
there
is
noteworthy
trend
in
SWBNNTs
various
chiralities.
includes
modulus
nanocomposite,
ranging
from
0).
Similarly,
exhibits
an
then
decreases
at
To
validate
accuracy
these
findings,
Radial
Distribution
Function
(RDF)
diagram
generated
Materials
Studio
software.
Tissue Engineering Part A,
Journal Year:
2024,
Volume and Issue:
30(13-14), P. 387 - 408
Published: Jan. 11, 2024
Bioprinting
describes
the
printing
of
biomaterials
and
cell-laden
or
cell-free
hydrogels
with
various
combinations
embedded
bioactive
molecules.
It
encompasses
precise
patterning
cells
to
create
scaffolds
for
different
biomedical
needs.
There
are
many
requirements
that
bioprinting
face,
it
is
ultimately
interplay
between
scaffold's
structure,
properties,
processing,
performance
will
lead
its
successful
translation.
Among
essential
properties
must
possess—adequate
appropriate
application-specific
chemical,
mechanical,
biological
performance—the
mechanical
behavior
hydrogel-based
bioprinted
key
their
stable
in
vivo
at
site
implantation.
Hydrogels
typically
constitute
main
scaffold
material
medium
biomolecules
very
soft,
often
lack
sufficient
stability,
which
reduces
printability
and,
therefore,
potential.
The
aim
this
review
article
highlight
reinforcement
strategies
used
approaches
achieve
enhanced
stability
bioinks
printed
scaffolds.
Enabling
robust
materials
processes
creation
truly
complex
remarkable
structures
could
accelerate
application
smart,
functional
settings.
a
powerful
tool
fabrication
3D
applications.
has
gained
tremendous
attention
recent
years,
bioink
library
expanding
include
more
combinations.
From
practical
perspective,
need
be
considered,
such
as
structure's
performances.
these,
constructs
critical
translation
into
clinic.
explore
stabilization
structures.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2520 - 2520
Published: March 11, 2025
Melatonin,
a
natural
hormone
with
antioxidant,
anti-inflammatory,
and
regenerative
properties,
has
gained
increasing
attention
in
tissue
engineering
for
its
ability
to
enhance
the
therapeutic
potential
of
biopolymeric
scaffolds.
These
scaffolds,
designed
mimic
extracellular
matrix,
provide
structural
support
bioactive
environment
regeneration.
By
integrating
melatonin,
researchers
aim
create
multifunctional
scaffolds
that
promote
cell
proliferation,
modulate
inflammatory
responses,
improve
wound
healing
outcomes.
Challenges
utilizing
melatonin
include
maintaining
stability
under
light,
heat,
oxygen
exposure,
optimizing
release
profile
sustained
effects.
Innovative
fabrication
methods,
such
as
electrospinning,
3D
printing,
lyophilization,
have
enabled
precise
control
over
scaffold
architecture
delivery.
techniques
ensure
enhanced
interactions
target
tissues
tailored
regeneration
processes.
Combining
growth
factors,
cytokines,
antimicrobial
agents
offers
applications,
from
chronic
management
bone
nerve
Continued
research
this
field
promises
transformative
solutions
medicine,
expanding
clinical
applicability
melatonin-enriched
This
review
highlights
current
progress,
challenges,
opportunities
associated
harnessing
melatonin’s
within
frameworks.