Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(11), P. 2725 - 2725
Published: Oct. 27, 2022
Finasteride
(Fin)
causes
androgen
imbalance
by
inhibiting
the
conversion
of
testosterone
(T)
to
its
more
active
metabolite,
dihydrotestosterone
(DHT).
Androgen
receptors
(AR)
are
present
(e.g.,
in
hepatocytes),
which
have
well-developed
endoplasmic
reticulum
(ERet).
Cellular
protein
quality
control
is
carried
out
ERet
two
paths:
(i)
unfolded
response
(UPR)
and/or
(ii)
associated
degradation
(ERAD).
under
continuous
stress
can
generate
changes
UPR
and
direct
cell
on
pathway
life
or
death.
It
has
been
demonstrated
that
genes
involved
among
controlled
androgens
some
tissues.
Oxidative
also
one
factors
affecting
functions
regulators
antioxidant
enzyme
activity.
In
this
paper,
we
discuss/analyze
a
possible
relationship
between
paternal
generation
with
liver
disorders
both
filial
generation.
our
rat
model,
hyperglycemia
subsequent
higher
accumulation
hepatic
glycogen
were
observed
all
obtained
from
females
fertilized
Fin-treated
males
(F1:Fin).
Importantly,
encoding
enzymes
glucose
metabolism
previously
recognized
targets.
Endocrine Metabolic & Immune Disorders - Drug Targets,
Journal Year:
2023,
Volume and Issue:
23(14), P. 1740 - 1749
Published: Feb. 27, 2023
Background:
Prenatal
period
is
a
critical
developmental
phase
that
sensitive
to
hormonal
disruption
by
natural
and/or
exogenous
hormones.
Some
pharmaceuticals
frequently
prescribed
and
used
safely
during
pregnancy
are
shown
interact
with
the
programming
of
fetus,
resulting
in
endocrine-related
adverse
effects.
Objective:
In
this
research,
we
aimed
determine
endocrine
disrupting
potential
paracetamol,
indomethacin,
alpha-methyldopa
pantoprazole
which
dur-ing
pregnancy.
Methods:
vitro
aromatase
inhibitory,
estrogen
receptor
(ER)
agonist/antagonist
(E-Screen
assay)
hormone
biosynthesis
modulatory
effects
(H295R
steroidogenesis
selected
were
evaluated.
Furthermore,
their
on
viability
MCF-7/BUS
H295R
cells
also
evalu-ated
MTT
assay.
Results:
None
affected
cell
viability.
Only
indomethacin
reduced
at
100μM
300μM.
Among
tested
pharmaceuticals,
only
paracetamol
showed
inhibitory
activity
IC50
values
14.7
x
10-5
M
57.6
M,
respectively.
Moreover,
displayed
biphasic
ER
agonist
effect.
antagonist
confirmed
performing
two
stepped
E-Screen
After
partial
validation
assay
forskolin
prochloraz,
phar-maceuticals
synthesis
testosterone
(T)
estradiol
(E2)
levels
tested.
Alpha-methyldopa
increased
E2
all
concentrations
T
1.48
4.4μM.
Contrarily
other
did
not
affect
steroidogenesis.
Conclusion:
Present
data
suggest
may
have
effect,
should
be
considered
when
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(11), P. 2725 - 2725
Published: Oct. 27, 2022
Finasteride
(Fin)
causes
androgen
imbalance
by
inhibiting
the
conversion
of
testosterone
(T)
to
its
more
active
metabolite,
dihydrotestosterone
(DHT).
Androgen
receptors
(AR)
are
present
(e.g.,
in
hepatocytes),
which
have
well-developed
endoplasmic
reticulum
(ERet).
Cellular
protein
quality
control
is
carried
out
ERet
two
paths:
(i)
unfolded
response
(UPR)
and/or
(ii)
associated
degradation
(ERAD).
under
continuous
stress
can
generate
changes
UPR
and
direct
cell
on
pathway
life
or
death.
It
has
been
demonstrated
that
genes
involved
among
controlled
androgens
some
tissues.
Oxidative
also
one
factors
affecting
functions
regulators
antioxidant
enzyme
activity.
In
this
paper,
we
discuss/analyze
a
possible
relationship
between
paternal
generation
with
liver
disorders
both
filial
generation.
our
rat
model,
hyperglycemia
subsequent
higher
accumulation
hepatic
glycogen
were
observed
all
obtained
from
females
fertilized
Fin-treated
males
(F1:Fin).
Importantly,
encoding
enzymes
glucose
metabolism
previously
recognized
targets.
