Long-term outcomes of hospitalized patients with SARS-CoV-2/COVID-19 with and without neurological involvement: 3-year follow-up assessment

PLoS Medicine, Journal Year: 2024, Volume and Issue: 21(4), P. e1004263 - e1004263

Published: April 4, 2024

Background Acute neurological manifestation is a common complication of acute Coronavirus Disease 2019 (COVID-19) disease. This retrospective cohort study investigated the 3-year outcomes patients with and without significant manifestations during initial COVID-19 hospitalization. Methods findings Patients hospitalized for Severe Respiratory Syndrome 2 (SARS-CoV-2) infection between 03/01/2020 4/16/2020 in Montefiore Health System Bronx, an epicenter early pandemic, were included. Follow-up data was captured up to 01/23/2023 (3 years post-COVID-19). consisted 414 1,199 propensity-matched (for age severity score) manifestations. Neurological involvement phase included stroke, new or recrudescent seizures, anatomic brain lesions, presence altered mentation evidence impaired cognition arousal, neuro-COVID-19 complex (headache, anosmia, ageusia, chemesthesis, vertigo, presyncope, paresthesias, cranial nerve abnormalities, ataxia, dysautonomia, skeletal muscle injury normal orientation arousal signs). There no group differences female sex composition (44.93% versus 48.21%, p = 0.249), ICU IMV status, white, not Hispanic (6.52% 7.84%, 0.380), (33.57% 38.20%, 0.093), except black non-Hispanic (42.51% 36.03%, 0.019). Primary mortality, heart attack, major adverse cardiovascular events (MACE), reinfection, hospital readmission post-discharge. Secondary neuroimaging (hemorrhage, active prior mass effect, microhemorrhages, white matter changes, microvascular disease (MVD), volume loss). More discharged rehabilitation (10.39% 3.34%, < 0.001) skilled nursing facilities (35.75% 25.35%, fewer home (50.24% 66.64%, than matched controls. Incidence any reason (65.70% 60.72%, 0.036), stroke (6.28% 2.34%, 0.001), MACE (20.53% 16.51%, 0.032) higher Per Kaplan–Meier univariate survival curve analysis, such more likely die post-discharge compared controls (hazard ratio: 2.346, (95% confidence interval (CI) [1.586, 3.470]; 0.001)). Across both cohorts, causes death (13.79% neurological, 15.38% control), sepsis (8.63%, 17.58%), influenza pneumonia (13.79%, 9.89%), (10.34%, 7.69%), respiratory distress syndrome (ARDS) 6.59%). Factors associated mortality after leaving involved (odds ratio (OR): 1.802 CI [1.237, 2.608]; 0.002)), discharge disposition (OR: 1.508 [1.276, 1.775]; 0.001)), congestive failure 2.281 [1.429, 3.593]; score 1.177 [1.062, 1.304]; older 1.027 [1.010, 1.044]; 0.002)). radiological findings, that showed significantly age-adjusted loss ( 0.045) The study’s patient limited infected first wave when hospitals overburdened, vaccines yet available, treatments limited. Patient profiles might differ interrogating subsequent waves. Conclusions had worse long-term These raise awareness need closer monitoring timely interventions manifestations, as their course involving enhanced morbidity mortality.

Language: Английский

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COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 7, 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans can lead to various degrees of tissue and organ damage, which cardiovascular system diseases are one the main manifestations, such as myocarditis, myocardial infarction, arrhythmia, threaten infected population worldwide. These health populations Although prevalence disease 2019 (COVID-19) has slightly improved with virus mutation vaccination, chronic infection, post-infection sequelae, patients still exist, it is relevant study mechanisms linking COVID-19 (CVD). This article introduces pathophysiological mechanism COVID-19-mediated analyzes recent progress interaction between SARS-CoV-2 from roles angiotensin-converting enzyme (ACE2), cellular molecular mechanisms, endothelial dysfunction, insulin resistance, iron homeostasis imbalance, psychosocial factors, respectively. We also discussed differences involved combined neocoronavirus different provided a theoretical basis for better prevention management.

Language: Английский

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Elemental evaluation, nutritional analysis, GC-MS analysis and ameliorative effects of Artocarpus communis J.R.Forst. & G.Forst. seeds’ phytoconstituents on metabolic syndrome via in silico approach

Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 19, 2023

The nutritional as well beneficial effects of the Artocarpus communis seed on metabolic syndrome complications have not been studied. In this research, aim was to investigate composition and seeds' phytoconstituents p53 core, fat mass obesity-associated (FTO) protein cytochrome P450 CYP11A1 domains. elements phytochemicals in were determined through atomic absorption spectroscopy assay gas chromatography-mass spectrometry (GC-MS) analysis, respectively. Also, compounds detected docked FTO domains protein. contains sodium (7.824 ± 0.0134 ppm), magnesium (10.187 0.0239 ppm) iron (1.924 0.0017), while zinc cadmium undetected. Phenolics flavonoids most abundant seed. Phytoconstituents, such pentadecanoic acid, hexadecanoic acid methyl ester, possessing different therapeutic identified via GC-MS analysis. A. seed, 3-methyl-4-nitro-5-(1-pyrazolyl) pyrazole phenanthrene able bind more peculiarly specifically One important processes that hypothesized for recovery affected victims is shown by molecular dynamics which shows binding these chemicals targeted structure stabilized proteins. Therefore, seeds could be a new strategy management syndrome.Communicated Ramaswamy H. Sarma.

Language: Английский

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DPP4 inhibitors and the matters of metaflammation!

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111605 - 111605

Published: March 1, 2025

Language: Английский

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Assessment of physician preparedness for implementation of pathology-supported genetic testing: solution-driven post-COVID-19 survey

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Introduction Rapid advances in personalized medicine and direct-to-consumer genomic applications could increase the risk that physicians will apply results inappropriately. To address a persistent lack of understanding genomics, we implemented pathology-supported genetic testing (PSGT) approach, guided by insights from clinician needs assessment conducted 2010. Methods Findings previous survey were used to develop new patient screening tool integrates non-communicable disease (NCD) post-COVID-19 care pathways. In parallel application this solution for stratification patients different treatment groups, an updated version original questionnaire was reassess knowledge willingness healthcare professionals PSGT. Results Thirty-six respondents completed revised October 2022, while attending genomics session at Annual General Practitioner Congress, Stellenbosch University, South Africa. Nearly 89% reported having insufficient offer testing; 80% supportive using PSGT differentiate inherited lifestyle- or therapy-associated NCDs 83.3% supported integrating wellness with identify high-risk individuals. Discussion It appears clinicians are interested learning about they continue report significant deficits area, highlighting need targeted training tools like multidisciplinary NCD-COVID pathway analysis improve clinical decision-making. The co-development counseling ongoing studies, selection Long COVID whole-genome sequencing across illness domains.

Language: Английский

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ЕФЕКТИВНІСТЬ ЗАСТОСУВАННЯ ТІВОРЕЛЮ ТА КВЕРЦЕТИНУ ПРИ ПОСТКОВІДНОМУ СИНДРОМІ У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2-ГО ТИПУ

Art of Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 13 - 17

Published: April 2, 2025

The aim of the study was to investigate effectiveness tivorel and quercetin in patients with type 2 diabetes ( T2D ) post-COVID syndrome by evaluating glucose metabolism, lipid systemic inflammation, endothelial function, hemostasis indicators during treatment. involved 40 who were hospitalized. Patients divided into two groups: main group 20 received (20 mg levocarnitine + 42 arginine hydrochloride, manufactured LLC "Yuria-Pharm") intravenously on a daily basis for 10 days, followed oral administration aspartate ml twice day) 21 days. In addition, they treated ("Quertin," PJSC "Borshchagivskiy HFZ") at dosage tablets, three times day (a dose 240 quercetin) one month. control included did not receive aforementioned therapy. spectrum blood plasma (total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C, LDL-C, VLDL-C) performed using diagnostic reagent kits. To assess state carbohydrate levels determined standard tolerance test (OGTT), as well glycosylated hemoglobin (HbA1c). Plasma fibrinolytic activity (TFA), enzymatic (EFA) non-enzymatic (NFA)), prothrombin time (PT), PI, APTT, factor XIII (FXIII), fibrinogen level, AT III methods. Serum C-reactive protein (CRP), interleukin-10 (IL-10), 8-isoprostane, D-dimer also measured ELISA. Endothelial function assessed stable metabolites nitric oxide (nitrites/nitrates), endothelin-1 (ET-1). use comprehensive therapy led reduction total (TC) (TG) serum 18.2% 22.4%, respectively, an increase (HDL-C) 38.6%. Significant reductions low-density (LDL-C), very (VLDL-C) atherogenic coefficient (AC) noted. Fasting decreased 1.8-fold, 2-hour dropped 44.3%, glycated 28.2% fasting test. This treatment had positive impact inflammation oxidative stress, indicated 8-isoprostane (at 30.6%), (CRP) 50.5%), Interleukin-1 (IL-1) 20.6%). 32.2%, (ET-1) 18.4%. Tivorel improved markers, including index (PTI), fibrinogen, D-dimer, activated partial thromboplastin (APTT), antithrombin (ATIII), activity. complex post-Covid is effective combination improving functional endothelium system.

Language: Английский

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Assessment of epicardial adipose tissue in patients with severe and critical COVID-19 pneumonia as a predictor of in-hospital mortality

Respiratory Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 108085 - 108085

Published: April 1, 2025

Language: Английский

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Global, regional, and national burden of ischemic heart disease attributable to metabolic risks: a systematic analysis of Global Burden of Disease 2021

Journal of Geriatric Cardiology, Journal Year: 2025, Volume and Issue: 22(3), P. 361 - 380

Published: March 1, 2025

Ischemic heart disease (IHD) represents the most significant burden among all cardiovascular diseases (CVDs). The increasing prevalence of metabolic risks in 21st century has a profound impact on associated with IHD. We analyzed global, regional, and national burdens IHD attributable to from 1990 2021. data were taken Global Burden Disease (GBD) study Deaths, disability-adjusted life years (DALYs), average annual percent change (AAPC), age-standardized death rates per 100,000 persons (ASDR) rate (ASR) DALYs ranging 2021, extracted stratified according region, nationality, socio-demographic index (SDI), sex, age. Additionally, global future trends predicted using Nordpred prediction model. Compared 1990, number risk-attributed increased globally by 67.35% 59.91%, respectively; whereas ASDR ASR showed decreasing trend severe was observed male elderly populations. In addition, an inverted V-shaped relationship SDI AAPC increase developing countries decrease developed countries. also effects different risk factors including regions genders. that will keep rising, while maintain certain downward trend. results this highlighted need for screening intervention specific populations, should call collaboration between reduce improve prognosis patients

Language: Английский

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New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 8, 2025

There is limited information on new-onset mental disorders in adults with metabolic diseases following the COVID-19 pandemic. Here, we aimed to examine changes health pandemic and identify factors associated development of disorders. Among 90,580 UK Biobank participants diagnosed between Jan 31, 2020 Oct 2022, those who completed both baseline follow-up questionnaires 2016-2017 2022-2023 were included analysis. New-onset depression, anxiety, alcohol use disorder pandemic, as well scores, assessed. Furthermore, their association sociodemographic, clinical, self-perceived emotional state-related exposures was examined. Prevalent significantly a higher risk depression (hypertension: odds ratio [OR], 1.22; 95% CI 1.01-1.47; diabetes: OR 1.8; 1.25-2.6; obesity: 1.66; 1.43-1.95) anxiety 1.32; 1.06-1.63; 1.06-2.62; 1.2; 0.99-1.44) significant increase Patient Health Questionnaire-9 (PHQ-9; beta, 0.32; 0.29-0.35) Generalized Anxiety Disorder-7 (GAD-7; 0.10; 0.06-0.13) scores throughout while Alcohol Use Disorder Identification Test (AUDIT) score decreased over time (beta, - 0.24; 0.30 0.18). Preexisting accelerated PHQ-9 GAD-7 Adults are an increased

Language: Английский

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Obesity and COVID-19 Pandemics: Epidemiology, Mechanisms, and Management

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2023, Volume and Issue: Volume 16, P. 4147 - 4156

Published: Dec. 1, 2023

Obesity is a principle causative factor of various metabolic dysfunctions, chronic inflammation, and multi-organ impairment. The global epidemic obesity has constituted the greatest threat to health. Emerging evidence associated with an increased risk severe infection poor outcomes from coronavirus disease 2019 (COVID-19). During current COVID-19 pandemic, interaction between exaggerated burden more than ever before. Thus, there urgent need for consideration universal measures reduce complications illness acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in population. In this review, we first summarized clinical on effect susceptibility, severity, prognosis COVID-19. Then discussed underlying mechanisms, including pathophysiology obesity, dysregulated upregulated angiotensin-converting enzyme 2 (ACE2) expression, hyperglycemia, adipokines. Finally, proposed recommendations how spread pandemic SARS-CoV-2 by prevention treatment obesity.

Language: Английский

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