Obesity and tobacco smoking are independently associated with poor patient-reported outcomes in SLE: a cross-sectional study

Rheumatology International, Journal Year: 2024, Volume and Issue: 44(5), P. 851 - 861

Published: March 7, 2024

Abstract We investigated associations of obesity and tobacco smoking with health-related quality life (HRQoL), pain, fatigue, functional impairment in systemic lupus erythematosus (SLE). Furthermore, we explored whether there was an effect modification between these two factors. included adult SLE patients from the Linköping University Hospital ( n = 325) present cross-sectional analysis. further population-based controls performed cardinality matching to balance age sex distributions cases 224). HRQoL assessed EQ-5D index score; overall SLE-related health state visual analogue scales (VAS; 0 [best] 100 [worst]); HAQ-DI. Unacceptable outcomes were defined as VAS scores corresponding 90th percentile derived matched controls. reported worse than all measures, approximately 30% experienced unacceptable outcomes. When compared normal-weight, obese lower HRQoL, greater risk pain (OR: 3.2; 95% CI 1.6–6.7) fatigue 2.1; 1.0–4.3). Similarly, current smokers higher levels a 3.8; 1.8–8.2) 2.8; 1.3–5.9) never smokers. The independent age, sex, disease duration, activity, organ damage. There no evidence synergistic increased BMI on any outcome. In summary, are factors for patient-reported SLE, regardless clinical activity.

Language: Английский

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Impact of Climate Change on Rheumatic Diseases: A Scoping Review

The Journal of Climate Change and Health, Journal Year: 2024, Volume and Issue: 19, P. 100338 - 100338

Published: Aug. 3, 2024

Although the impacts of climate change on human health conditions are reasonably well documented, specific influences rheumatic diseases remain incompletely characterized. The goal this scoping review was to better understand how is impacting diseases, either directly or indirectly, as affects geographical distribution infectious with arthritogenic manifestations, which will impact disease care. A conducted according Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping (PRISMA-ScR). 149 papers were identified regarding related exposures patients diseases. most common climate-related exposure air pollution, other factors including excess heat cold, precipitation, ultraviolet light, malnutrition. vast majority studies associations increased activity incidence. 105 that addressed influence observed projected changes in range manifestations spread by arthropods environmental vectors. focused dengue, Lyme chikungunya found an increase change. grey literature search rheumatology organization websites suggests field remains inadequately prepared impacts. existing summarized gaps highlighted deserving further exploration such rheumatologists can be care their patients, educate them potential harms, advocate policies proactively address crisis.

Language: Английский

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Health journey of Nigerian patients with systemic lupus erythematosus

Lupus, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Although there is an increase in prevalence and incidence of lupus worldwide, the journey to diagnosis unduly delayed. This delay associated with worse outcomes. Sub-Saharan Africa has witnessed recent decades no specific data on time lupus. We measured documented diagnostic delays, patients' experiences, factors delayed provided recommendations for early diagnosis. a three-month cross-sectional study 245 patients diagnosed who are members Nigerian support group. Included participants fill out administered questionnaire Google doc. The captured all aspects objectives. Four intervals were defined. Delayed was defined as interval from first symptoms greater than or equal 6 months. majority under 40 years age (n-187, 76.3%) predominantly female (n-226, 92.9%). About 53.9% between months 2 after their symptoms, while 42% visited doctor within symptom onset. Roughly half referred rheumatologists visit last doctor, 50.2% 4 weeks rheumatologist's evaluation. referral 80% 66.9% respectively. Low income (OR-7.4), internal organ manifestations (OR-4.5), multiple doctors' visits (OR-11.6) independently Diagnostic observed our patients. hospital visits, low income, manifestations. There should be concerted efforts SSA improve rheumatology workforce incorporate non-specialists clinical service delivery.

Language: Английский

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Patient‐Reported Social Risk Factor Screening Among Rheumatology Outpatients

ACR Open Rheumatology, Journal Year: 2025, Volume and Issue: 7(3)

Published: March 1, 2025

The purpose of this study was to pilot test a patient-reported social risk factor (SRF) screening tool among rheumatology outpatients and examine the distribution SRFs in population. A SRF completed electronically by patients. Patients were screened for four core domains (financial strain, housing instability, food insecurity, transportation needs) supplemental (physical inactivity, isolation, stress, depression). Data from electronic health record extracted patients with at least one domain who seen participating providers between January 1 October 31, 2023. Descriptive statistics multivariable logistic regressions used trends associations sample included 483 patients, 84% positive SRF. Physical inactivity (73%, 311 429) isolation (58%, 212 367) most common SRFs. Prevalence 35% financial strain (145 412), 22% instability (82 370), 23% insecurity (96 420), 11% needs (48 427). Sociodemographic groups higher prevalence reporting Medicaid insurance, younger age, Black race, or unmarried status. Multivariate analyses showed that insurance increased odds all domains. Our identified high burden outpatients, giving new level detail into patients' barriers possible needs. Future work will uncover clinical outcomes evaluate impact interventions address

Language: Английский

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Addressing the research gap: access to care hinders genetic discovery in systemic lupus erythematosus patients throughout the African diaspora

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune condition that disproportionately impacts non-White ethnic and racial groups, particularly individuals in the African diaspora who experience heightened incidence, prevalence, adverse outcomes. Genetic epigenetic factors play significant roles SLE risk, however these neither explain whole of risk nor stark disparities we observe. Moreover, our understanding genetic within ancestry populations limited due to social environmental influences on research participation, disease presentation, healthcare access. Globally, faces barriers accessing essential diagnostic tools, therapeutics, practitioners, high-quality clinical translational studies. Here, provide insights into current state studies highlight unique challenges encountered care across countries varying income levels. We also identify opportunities address promote scientific equity for affected by global diaspora.

Language: Английский

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Interpreting and Addressing Racialized Inequities in Rheumatic Disease Care and Outcomes

Arthritis Care & Research, Journal Year: 2024, Volume and Issue: 76(7), P. 908 - 913

Published: May 16, 2024

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

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Lupus and other autoimmune diseases: epidemiology in the population of African ancestry, and diagnostic and management challenges in Africa

Journal of Allergy and Clinical Immunology Global, Journal Year: 2024, Volume and Issue: 3(4), P. 100288 - 100288

Published: June 1, 2024

Autoimmune diseases are prevalent among people of African ancestry living outside Africa. However, the burden autoimmune in Africa is not well understood. This article provides a global overview current individuals descent. It also discusses major factors contributing to this population group, as challenges involved diagnosing and managing

Language: Английский

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Multisystem inflammatory syndrome in adults hospitalizations in the United States; evaluating patient characteristics, COVID-19 associations, and mortality

Archives of Medical Science - Atherosclerotic Diseases, Journal Year: 2024, Volume and Issue: 9(1), P. 165 - 170

Published: Sept. 16, 2024

Introduction Multisystem inflammatory syndrome in adults (MIS-A) is thought to be closely linked with COVID-19 infection. This study aims elucidate the demographics and clinical characteristics of MIS-A, aiding timely diagnosis management. Methods Utilizing National Inpatient Sample (NIS) database (2021), patients were stratified into MIS-A non-MIS-A groups. Baseline comorbidities, association COVID-19, post-COVID-19 syndrome, personal history as well impact on mortality studied. Results We identified 2,730 MIS-A. was active infection (aOR = 27.436, <i>p</i> < 0.001), 32.766, 2.963, an increased 3.743, 0.001). Conclusions Using data adjusted for confounding variables, found associated past a greater rate when compared patients.

Language: Английский

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