Association Between the Use of Oral Contraceptives and the Development of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis DOI Open Access
Annalisa Marino, Damiano Currado, Onorina Berardicurti

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2710 - 2710

Published: April 15, 2025

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that significantly impacts quality of life, particularly among women. Previous studies have suggested oral contraceptive (OC) use may influence RA risk, but conflicting findings from earlier meta-analyses necessitate an updated analysis incorporating more recent data. Methods: We conducted systematic review and meta-analysis observational on OC risk by searching MedLine (via PubMed), Scopus, Cochrane Databases up to September 2024. Results: Our demonstrated current or prior OCs associated with statistically significant reduction in (OR 0.80, 95% CI 0.70–0.91). In contrast, the associations for 0.59, 0.34–1.02) past 0.83, 0.69–1.01) were less definitive, likely due substantial heterogeneity studies. Cumulative revealed modest temporal trend toward protective effect use. Conclusions: This supports association between development RA, highlighting potential role hormonal factors pathogenesis.

Language: Английский

Effects of nutritional supplements and dietary interventions on rheumatoid arthritis: An umbrella review of meta-analyses of randomized controlled trials DOI

Xueer Cheng,

Xiao Hu, Jian Tang

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(6), P. 103792 - 103792

Published: March 6, 2025

Language: Английский

Citations

0
Association Between the Use of Oral Contraceptives and the Development of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis DOI Open Access
Annalisa Marino, Damiano Currado, Onorina Berardicurti

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2710 - 2710

Published: April 15, 2025

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that significantly impacts quality of life, particularly among women. Previous studies have suggested oral contraceptive (OC) use may influence RA risk, but conflicting findings from earlier meta-analyses necessitate an updated analysis incorporating more recent data. Methods: We conducted systematic review and meta-analysis observational on OC risk by searching MedLine (via PubMed), Scopus, Cochrane Databases up to September 2024. Results: Our demonstrated current or prior OCs associated with statistically significant reduction in (OR 0.80, 95% CI 0.70–0.91). In contrast, the associations for 0.59, 0.34–1.02) past 0.83, 0.69–1.01) were less definitive, likely due substantial heterogeneity studies. Cumulative revealed modest temporal trend toward protective effect use. Conclusions: This supports association between development RA, highlighting potential role hormonal factors pathogenesis.

Language: Английский

Citations

0