Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2710 - 2710
Published: April 15, 2025
Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that significantly impacts quality of life, particularly among women. Previous studies have suggested oral contraceptive (OC) use may influence RA risk, but conflicting findings from earlier meta-analyses necessitate an updated analysis incorporating more recent data. Methods: We conducted systematic review and meta-analysis observational on OC risk by searching MedLine (via PubMed), Scopus, Cochrane Databases up to September 2024. Results: Our demonstrated current or prior OCs associated with statistically significant reduction in (OR 0.80, 95% CI 0.70–0.91). In contrast, the associations for 0.59, 0.34–1.02) past 0.83, 0.69–1.01) were less definitive, likely due substantial heterogeneity studies. Cumulative revealed modest temporal trend toward protective effect use. Conclusions: This supports association between development RA, highlighting potential role hormonal factors pathogenesis.
Language: Английский