Cited by Advancing nerve regeneration: Peripheral nerve injury (PNI) chip empowering high-speed biomaterial and drug screening

Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair DOI

Juqing Song,

Baiheng Lv,

Wencong Chen

et al.

International Journal of Extreme Manufacturing, Journal Year: 2023, Volume and Issue: 5(3), P. 032008 - 032008

Published: June 13, 2023

Abstract Because of the complex nerve anatomy and limited regeneration ability natural tissue, current treatment effect for long-distance peripheral spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering a promising method to regenerate cord, can provide structures functions similar tissues through scaffold materials seed cells. Recently, rapid development 3D printing technology enables researchers create novel constructs with sophisticated diverse achieve high bionics functions. In this review, we first outlined as well strategies SCI in clinical. After that, design considerations were discussed, various technologies applicable neural elaborated, including inkjet, extrusion-based, stereolithography, projection-based, emerging technologies. Finally, focused on application repair, challenges prospects research field.

Language: Английский

Citations

Aligned Electroactive Electrospun Fibrous Scaffolds for Peripheral Nerve Regeneration DOI

Feng Xiong, Shuo Wei,

Shuyuan Wu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(35), P. 41385 - 41402

Published: Aug. 22, 2023

Effective repair and functional recovery of large peripheral nerve deficits are urgent clinical needs. A biofunctional electroactive scaffold typically acts as a "bridge" for the defects. In this study, we constructed biomimetic piezoelectric conductive aligned polypyrrole (PPy)/polydopamine (PDA)/poly-l-lactic acid (PLLA) electrospun fibrous to improve hydrophilicity cellular compatibility PLLA restore weakened effect PDA, which is beneficial in promoting Schwann cell differentiation dorsal root ganglion neuronal extension alignment. The PPy/PDA/PLLA bridged sciatic Sprague-Dawley rats with 10 mm deficit, prevented autotomy, promoted regeneration recovery, thereby activating calcium AMP-activated protein kinase signaling pathways. Therefore, scaffolds exhibit great potential neural tissue regeneration.

Language: Английский

Citations

Highly oriented hydrogels for tissue regeneration: design strategies, cellular mechanisms, and biomedical applications DOI

Jiuping Wu,

Zhihe Yun,

Wenlong Song

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 1982 - 2035

Published: Jan. 1, 2024

Many human tissues exhibit a highly oriented architecture that confers them with distinct mechanical properties, enabling adaptation to diverse and challenging environments. Hydrogels, their water-rich "soft wet" structure, have emerged as promising biomimetic materials in tissue engineering for repairing replacing damaged organs. Highly hydrogels can especially emulate the structural orientation found tissue, exhibiting unique physiological functions properties absent traditional homogeneous isotropic hydrogels. The design preparation of involve strategies like including nanofillers, polymer-chain networks, void channels, microfabricated structures. Understanding specific mechanism action how these affect cell behavior biological applications such cornea, skin, skeletal muscle, tendon, ligament, cartilage, bone, blood vessels, heart, etc., requires further exploration generalization. Therefore, this review aims fill gap by focusing on strategy application field engineering. Furthermore, we provide detailed discussion various organs mechanisms through which structures influence behavior.

Language: Английский

Citations

Multistructured hydrogel promotes nerve regeneration DOI

Ning Zhu, Yaping Zhuang,

Wanju Sun

et al.

Materials Today Advances, Journal Year: 2024, Volume and Issue: 21, P. 100465 - 100465

Published: Feb. 7, 2024

Hydrogels have emerged as promising biomaterials for nerve regeneration due to their adjustable properties, structural resemblance the extracellular matrix, and ability promote cell adhesion proliferation. This comprehensive review discusses advantages, challenges, future directions of various functional hydrogels. Advanced technologies fabricating Multistructured hydrogel, including injectable hydrogels, hydrogel microspheres, fibrous 3D printing nanogels, stem cell-loaded electrical ultrasound magnetic been developed studied regeneration. These demonstrate versatility hydrogels in neural tissue repair. However, challenges such biocompatibility, degradation rates, scaffold design need be addressed. Interdisciplinary research is necessary develop innovative systems that overcome these realize potential provides valuable insights into advanced highlights regenerative medicine, particularly Researchers can use this knowledge refine therapeutic approaches involving enhancing

Language: Английский

Citations

Advancing nerve regeneration: Peripheral nerve injury (PNI) chip empowering high-speed biomaterial and drug screening DOI

Dong-Hee Lee, Huy Quang Tran, Andrew T. Dudley

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 486, P. 150210 - 150210

Published: March 6, 2024

Language: Английский

Citations