Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

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Calcium silicate nanowires-containing multicellular bioinks for 3D bioprinting of neural-bone constructs

Nano Today, Journal Year: 2022, Volume and Issue: 46, P. 101584 - 101584

Published: Aug. 9, 2022

Language: Английский

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Smart, Biomimetic Periosteum Created from the Cerium(III, IV) Oxide-Mineralized Eggshell Membrane

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(12), P. 14103 - 14119

Published: March 19, 2022

The periosteum orchestrates the microenvironment of bone regeneration, including facilitating local neuro-vascularization and regulating immune responses. To mimic role natural for repair enhancement, we adopted principle biomimetic mineralization to delicately inlay amorphous cerium oxide within eggshell membranes (ESMs) first time. Cerium from possesses unique ability switch its oxidation state III IV vice versa, which provides itself promising potential biomedical applications. ESMs are mineralized with cerium(III, IV) examined their biocompatibility. Apart serving as physical barriers, periosteum-like oxide-mineralized biocompatible can actively regulate responses facilitate along early-stage regeneration in a murine cranial defect model. During healing process, cerium-inlayed boost early osteoclastic differentiation macrophage lineage cells, may be dominant mediator microenvironment. present work novel insights into expanding definition function optimize long-term robust neuro-vascularization. This new treatment strategy employs multifunctional bone-and-periosteum-mimicking systems creates highly concerted expedite regeneration.

Language: Английский

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3D printing of biomaterials for vascularized and innervated tissue regeneration

International Journal of Bioprinting, Journal Year: 2023, Volume and Issue: 9(3), P. 706 - 706

Published: March 10, 2023

Neurovascular networks play significant roles in the metabolism and regeneration of many tissues organs human body. Blood vessels can transport sufficient oxygen, nutrients, biological factors, while nerve fibers transmit excitation signals to targeted cells. However, traditional scaffolds cannot satisfy requirement stimulating angiogenesis innervation a timely manner due complexity host neurovascular networks. Three-dimensional (3D) printing, as versatile favorable technique, provides an effective approach fabricating with biomimetic architectures multimaterial compositions, which are capable regulating multiple cell behaviors. This review paper presents summary current progress 3D-printed biomaterials for vascularized innervated tissue by presenting skin, bone, skeletal muscle example. In addition, we highlight crucial blood process discuss future perspectives engineering novel biomaterials. It is expected that properties not only recapitulate physiological microenvironment damaged but also rapidly integrate networks, resulting accelerated functional regeneration.

Language: Английский

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Thermodynamic 2D Silicene for Sequential and Multistage Bone Regeneration

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(13)

Published: Jan. 24, 2023

Bone healing is a multistage process involving the recruitment of cells, revascularization, and osteogenic differentiation, all which are modulated in temporal sequence to maximize cascade bone regeneration. However, insufficient osteoblast poor blood supply, limited induction at site critical-sized defect broadly impede repair. 2D SiO

Language: Английский

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